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001     154309
005     20240223115102.0
024 7 _ |a 10.1016/j.celrep.2020.108182
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037 _ _ |a DZNE-2021-00163
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Herde, Michel K
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245 _ _ |a Local Efficacy of Glutamate Uptake Decreases with Synapse Size.
260 _ _ |a [New York, NY]
|c 2020
|b Elsevier
336 7 _ |a article
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520 _ _ |a Synaptically released glutamate is largely cleared by glutamate transporters localized on perisynaptic astrocyte processes. Therefore, the substantial variability of astrocyte coverage of individual hippocampal synapses implies that the efficacy of local glutamate uptake and thus the spatial fidelity of synaptic transmission is synapse dependent. By visualization of sub-diffraction-limit perisynaptic astrocytic processes and adjacent postsynaptic spines, we show that, relative to their size, small spines display a stronger coverage by astroglial transporters than bigger neighboring spines. Similarly, glutamate transients evoked by synaptic stimulation are more sensitive to pharmacological inhibition of glutamate uptake at smaller spines, whose high-affinity N-methyl-D-aspartate receptors (NMDARs) are better shielded from remotely released glutamate. At small spines, glutamate-induced and NMDAR-dependent Ca2+ entry is also more strongly increased by uptake inhibition. These findings indicate that spine size inversely correlates with the efficacy of local glutamate uptake and thereby likely determines the probability of synaptic crosstalk.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
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650 _ 7 |a astrocyte morphology
|2 Other
650 _ 7 |a astrocytes
|2 Other
650 _ 7 |a expansion microscopy
|2 Other
650 _ 7 |a glutamate uptake
|2 Other
650 _ 7 |a hippocampus
|2 Other
650 _ 7 |a multiphoton imaging
|2 Other
650 _ 7 |a spine morphology
|2 Other
650 _ 2 |a Amino Acid Transport System X-AG: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Astrocytes: metabolism
|2 MeSH
650 _ 2 |a Calcium: metabolism
|2 MeSH
650 _ 2 |a Cell Size
|2 MeSH
650 _ 2 |a Dendritic Spines: metabolism
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Glutamic Acid: metabolism
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Receptors, N-Methyl-D-Aspartate: metabolism
|2 MeSH
650 _ 2 |a Synapses: metabolism
|2 MeSH
700 1 _ |a Bohmbach, Kirsten
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700 1 _ |a Domingos, Cátia
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700 1 _ |a Vana, Natascha
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700 1 _ |a Komorowska-Müller, Joanna A
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700 1 _ |a Passlick, Stefan
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700 1 _ |a Schwarz, Inna
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700 1 _ |a Jackson, Colin J
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700 1 _ |a Dietrich, Dirk
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700 1 _ |a Schwarz, Martin K
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700 1 _ |a Henneberger, Christian
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773 _ _ |a 10.1016/j.celrep.2020.108182
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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