TY  - JOUR
AU  - Palleis, Carla
AU  - Sauerbeck, Julia
AU  - Beyer, Leonie
AU  - Harris, Stefanie
AU  - Schmitt, Julia
AU  - Morenas-Rodriguez, Estrella
AU  - Finze, Anika
AU  - Nitschmann, Alexander
AU  - Ruch-Rubinstein, Francois
AU  - Eckenweber, Florian
AU  - Biechele, Gloria
AU  - Blume, Tanja
AU  - Shi, Yuan
AU  - Weidinger, Endy
AU  - Prix, Catharina
AU  - Bötzel, Kai
AU  - Danek, Adrian
AU  - Rauchmann, Boris-Stephan
AU  - Stöcklein, Sophia
AU  - Lindner, Simon
AU  - Unterrainer, Marcus
AU  - Albert, Nathalie L.
AU  - Wetzel, Christian
AU  - Rupprecht, Rainer
AU  - Rominger, Axel
AU  - Bartenstein, Peter
AU  - Herms, Jochen
AU  - Perneczky, Robert
AU  - Haass, Christian
AU  - Levin, Johannes
AU  - Höglinger, Günter
AU  - Brendel, Matthias
TI  - In Vivo Assessment of Neuroinflammation in 4‐Repeat Tauopathies
JO  - Movement disorders
VL  - 36
IS  - 4
SN  - 1531-8257
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2021-00182
SP  - 883 - 894
PY  - 2021
N1  - ISSN 1531-8257 not unique: **3 hits**.
AB  - Sleep complaints are the most prevalent syndromes in older adults, particularly in women. Moreover, they are frequently accompanied with a high level of depression and stress. Although several diffusion tensor imaging (DTI) studies reported associations between sleep quality and brain white matter (WM) microstructure, it is still unclear whether gender impacts the effect of sleep quality on structural alterations, and whether these alterations mediate the effects of sleep quality on emotional regulation. We included 389 older participants (176 females, age = 65.5 ± 5.5 years) from the 1000BRAINS project. Neuropsychological examinations covered the assessments of sleep quality, depressive symptomatology, current stress level, visual working memory, and selective attention ability. Based on the DTI dataset, the diffusion parameter maps, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were calculated and normalized to a population-specific FA template. According to the global Pittsburgh Sleep Quality Index (PSQI), 119 poor sleepers (PSQI: 10∼17) and 120 good sleepers (PSQI: 3∼6) were identified. We conducted a two by two (good sleepers/poor sleepers) × (males/females) analysis of variance by using tract-based spatial statistics (TBSS) and JHU-ICBM WM atlas-based comparisons. Moreover, we performed a voxel-wise correlation analysis of brain WM microstructure with the neuropsychological tests. Finally, we applied a mediation analysis to explore if the brain WM microstructure mediates the relationship between sleep quality and emotional regulation. No significant differences in brain WM microstructure were detected on the main effect of sleep quality. However, the MD, AD, and RD of pontine crossing tract and bilateral inferior cerebellar peduncle were significant lower in the males than females. Voxel-wise correlation analysis revealed that FA and RD values in the corpus callosum were positively related with depressive symptomatology and negatively related with current stress levels. Additionally, we found a significantly positive association between higher FA values in visual-related WM tracts and better outcomes in a visual pattern recognition test. Furthermore, a mediation analysis suggested that diffusion metrics within the corpus callosum partially mediated the associations between poor sleep quality/high stress and depressive symptomatology.
KW  - Aged
KW  - Alzheimer Disease
KW  - Animals
KW  - Brain: diagnostic imaging
KW  - Brain: metabolism
KW  - Cross-Sectional Studies
KW  - Female
KW  - Humans
KW  - Male
KW  - Mice
KW  - Middle Aged
KW  - Supranuclear Palsy, Progressive: diagnostic imaging
KW  - Supranuclear Palsy, Progressive: genetics
KW  - Tauopathies: diagnostic imaging
KW  - Tauopathies: genetics
KW  - tau Proteins: genetics
KW  - tau Proteins: metabolism
LB  - PUB:(DE-HGF)16
C6  - pmid:33245166
DO  - DOI:10.1002/mds.28395
UR  - https://pub.dzne.de/record/154328
ER  -