Home > Publications Database > In Vivo Assessment of Neuroinflammation in 4‐Repeat Tauopathies > print

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005     20240612120602.0
024 7 _ |a 10.1002/mds.28395
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024 7 _ |a 1531-8257
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100 1 _ |a Palleis, Carla
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245 _ _ |a In Vivo Assessment of Neuroinflammation in 4‐Repeat Tauopathies
260 _ _ |a New York, NY
|c 2021
|b Wiley
336 7 _ |a article
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520 _ _ |a Sleep complaints are the most prevalent syndromes in older adults, particularly in women. Moreover, they are frequently accompanied with a high level of depression and stress. Although several diffusion tensor imaging (DTI) studies reported associations between sleep quality and brain white matter (WM) microstructure, it is still unclear whether gender impacts the effect of sleep quality on structural alterations, and whether these alterations mediate the effects of sleep quality on emotional regulation. We included 389 older participants (176 females, age = 65.5 ± 5.5 years) from the 1000BRAINS project. Neuropsychological examinations covered the assessments of sleep quality, depressive symptomatology, current stress level, visual working memory, and selective attention ability. Based on the DTI dataset, the diffusion parameter maps, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were calculated and normalized to a population-specific FA template. According to the global Pittsburgh Sleep Quality Index (PSQI), 119 poor sleepers (PSQI: 10∼17) and 120 good sleepers (PSQI: 3∼6) were identified. We conducted a two by two (good sleepers/poor sleepers) × (males/females) analysis of variance by using tract-based spatial statistics (TBSS) and JHU-ICBM WM atlas-based comparisons. Moreover, we performed a voxel-wise correlation analysis of brain WM microstructure with the neuropsychological tests. Finally, we applied a mediation analysis to explore if the brain WM microstructure mediates the relationship between sleep quality and emotional regulation. No significant differences in brain WM microstructure were detected on the main effect of sleep quality. However, the MD, AD, and RD of pontine crossing tract and bilateral inferior cerebellar peduncle were significant lower in the males than females. Voxel-wise correlation analysis revealed that FA and RD values in the corpus callosum were positively related with depressive symptomatology and negatively related with current stress levels. Additionally, we found a significantly positive association between higher FA values in visual-related WM tracts and better outcomes in a visual pattern recognition test. Furthermore, a mediation analysis suggested that diffusion metrics within the corpus callosum partially mediated the associations between poor sleep quality/high stress and depressive symptomatology.
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650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Alzheimer Disease
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Cross-Sectional Studies
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: diagnostic imaging
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: genetics
|2 MeSH
650 _ 2 |a Tauopathies: diagnostic imaging
|2 MeSH
650 _ 2 |a Tauopathies: genetics
|2 MeSH
650 _ 2 |a tau Proteins: genetics
|2 MeSH
650 _ 2 |a tau Proteins: metabolism
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700 1 _ |a Sauerbeck, Julia
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700 1 _ |a Beyer, Leonie
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700 1 _ |a Harris, Stefanie
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700 1 _ |a Schmitt, Julia
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700 1 _ |a Finze, Anika
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700 1 _ |a Shi, Yuan
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700 1 _ |a Weidinger, Endy
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700 1 _ |a Stöcklein, Sophia
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700 1 _ |a Lindner, Simon
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700 1 _ |a Unterrainer, Marcus
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700 1 _ |a Albert, Nathalie L.
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700 1 _ |a Wetzel, Christian
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700 1 _ |a Rupprecht, Rainer
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700 1 _ |a Rominger, Axel
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700 1 _ |a Bartenstein, Peter
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700 1 _ |a Herms, Jochen
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700 1 _ |a Perneczky, Robert
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700 1 _ |a Haass, Christian
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700 1 _ |a Levin, Johannes
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700 1 _ |a Höglinger, Günter
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700 1 _ |a Brendel, Matthias
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773 _ _ |a 10.1002/mds.28395
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