TY  - JOUR
AU  - Tetreault, Aaron M
AU  - Phan, Tony
AU  - Petersen, Kalen J
AU  - Claassen, Daniel O
AU  - Neth, Byran J
AU  - Graff-Radford, Jonathan
AU  - Albrecht, Franziska
AU  - Fliessbach, Klaus
AU  - Schneider, Anja
AU  - Synofzik, Matthis
AU  - Diehl-Schmid, Janine
AU  - Otto, Markus
AU  - Schroeter, Matthias L
AU  - Darby, Richard Ryan
TI  - Network Localization of Alien Limb in Patients with Corticobasal Syndrome.
JO  - Annals of neurology
VL  - 88
IS  - 6
SN  - 1531-8249
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - DZNE-2021-00202
SP  - 1118 - 1131
PY  - 2020
N1  - ISSN 1531-8249 not unique: **3 hits**.
AB  - Perirolandic atrophy occurs in corticobasal syndrome (CBS) but is not specific versus progressive supranuclear palsy (PSP). There is heterogeneity in the locations of atrophy outside the perirolandic cortex and it remains unknown why atrophy in different locations would cause the same CBS-specific symptoms. In prior work, we used a wiring diagram of the brain called the human connectome to localize lesion-induced disorders to symptom-specific brain networks. Here, we use a similar technique termed 'atrophy network mapping' to localize single-subject atrophy maps to symptom-specific brain networks.Single-subject atrophy maps were generated by comparing cortical thickness in patients with CBS versus controls. Next, we performed seed-based functional connectivity using a large normative connectome to determine brain regions functionally connected to each patient's atrophied locations.Patients with CBS had perirolandic atrophy versus controls at the group level, but locations of atrophy in CBS were heterogeneous outside of the perirolandic cortex at the single-subject level (mean spatial correlation = 0.04). In contrast, atrophy occurred in locations functionally connected to the perirolandic cortex in all patients with CBS (spatial correlation = 0.66). Compared with PSP, patients with CBS had atrophy connected to a network of higher-order sensorimotor regions beyond perirolandic cortex, matching a CBS atrophy network from a recent meta-analysis. Finally, atrophy network mapping identified a symptom-specific network for alien limb, matching a lesion-induced alien limb network and a network associated with agency in healthy subjects.We identified a syndrome-specific network for CBS and symptom-specific network for alien limb using single-subject atrophy maps and the human connectome. ANN NEUROL 2020;88:1118-1131.
KW  - Alien Limb Phenomenon: pathology
KW  - Aged
KW  - Alien Hand Syndrome: pathology
KW  - Atrophy: pathology
KW  - Case-Control Studies
KW  - Cerebral Cortex: pathology
KW  - Connectome
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Supranuclear Palsy, Progressive: pathology
KW  - Syndrome
LB  - PUB:(DE-HGF)16
C6  - pmid:32935385
DO  - DOI:10.1002/ana.25901
UR  - https://pub.dzne.de/record/154348
ER  -