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@ARTICLE{Meier:154352,
      author       = {Meier, Kolja and Merseburg, Andrea and Isbrandt, Dirk and
                      Marguet, Stephan Lawrence and Morellini, Fabio},
      title        = {{D}entate {G}yrus {S}harp {W}aves, a {L}ocal {F}ield
                      {P}otential {C}orrelate of {L}earning in the {D}entate
                      {G}yrus of {M}ice.},
      journal      = {The journal of neuroscience},
      volume       = {40},
      number       = {37},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.69657},
      reportid     = {DZNE-2021-00205},
      pages        = {7105-7118},
      year         = {2020},
      note         = {ISSN 1529-2401 not unique: **3 hits**.},
      abstract     = {The hippocampus plays an essential role in learning. Each
                      of the three major hippocampal subfields, dentate gyrus
                      (DG), CA3, and CA1, has a unique function in memory
                      formation and consolidation, and also exhibit distinct local
                      field potential (LFP) signatures during memory consolidation
                      processes in non-rapid eye movement (NREM) sleep. The
                      classic LFP events of the CA1 region, sharp-wave ripples
                      (SWRs), are induced by CA3 activity and considered to be an
                      electrophysiological biomarker for episodic memory. In LFP
                      recordings along the dorsal CA1-DG axis from sleeping male
                      mice, we detected and classified two types of LFP events in
                      the DG: high-amplitude dentate spikes (DSs), and a novel
                      event type whose current source density (CSD) signature
                      resembled that seen during CA1 SWR, but which, most often,
                      occurred independently of them. Because we hypothesize that
                      this event type is similarly induced by CA3 activity, we
                      refer to it as dentate sharp wave (DSW). We show that both
                      DSWs and DSs differentially modulate the
                      electrophysiological properties of SWR and multiunit
                      activity (MUA). Following two hippocampus-dependent memory
                      tasks, DSW occurrence rates, ripple frequencies, and ripple
                      and sharp wave (SW) amplitudes were increased in both, while
                      SWR occurrence rates in dorsal CA1 increased only after the
                      spatial task. Our results suggest that DSWs, like SWRs, are
                      induced by CA3 activity and that DSWs complement SWRs as a
                      hippocampal LFP biomarker of memory
                      consolidation.SIGNIFICANCE STATEMENT Awake experience is
                      consolidated into long-term memories during sleep. Memory
                      consolidation crucially depends on sharp-wave ripples
                      (SWRs), which are local field potential (LFP) patterns in
                      hippocampal CA1 that increase after learning. The dentate
                      gyrus (DG) plays a central role in the process of memory
                      formation, prompting us to cluster sharp waves (SWs) in the
                      DG [dentate SWs (DSWs)] during sleep. We show that both DSW
                      coupling to CA1 SWRs, and their occurrence rates, robustly
                      increase after learning trials. Our results suggest that the
                      DG is directly affected by memory consolidation processes.
                      DSWs may thus complement SWRs as a sensitive
                      electrophysiological biomarker of memory consolidation in
                      mice.},
      keywords     = {Animals / Brain Waves / Dentate Gyrus: physiology / Male /
                      Memory / Mice / Mice, Inbred C57BL / Sleep, REM /
                      Wakefulness / dentate gyrus (Other) / dentate sharp wave
                      (Other) / dentate spike (Other) / hippocampus (Other) /
                      sharp-wave ripple (Other)},
      cin          = {AG Isbrandt},
      ddc          = {610},
      cid          = {I:(DE-2719)1011003},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32817247},
      pmc          = {pmc:PMC7480236},
      doi          = {10.1523/JNEUROSCI.2275-19.2020},
      url          = {https://pub.dzne.de/record/154352},
}