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000154358 0247_ $$2doi$$a10.1016/j.vaa.2019.10.013
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000154358 0247_ $$2ISSN$$a0950-7817
000154358 0247_ $$2ISSN$$a1351-6574
000154358 0247_ $$2ISSN$$a1467-2987
000154358 0247_ $$2ISSN$$a1467-2995
000154358 037__ $$aDZNE-2021-00211
000154358 041__ $$aEnglish
000154358 082__ $$a630
000154358 1001_ $$0P:(DE-HGF)0$$aMetzner, Moritz$$b0
000154358 245__ $$aUse of metamizole as an additional analgesic during umbilical surgery in calves.
000154358 260__ $$aAmsterdam$$bElsevier$$c2020
000154358 3367_ $$2DRIVER$$aarticle
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000154358 520__ $$aTo investigate the effect of metamizole on physiologic variables in calves undergoing surgical extirpation of the navel during anaesthesia using xylazine, ketamine and isoflurane.Double-blind, randomized trial.A total of 26 calves.Calves with uncomplicated umbilical hernias and otherwise clinically healthy were randomly allocated to one of two groups: the control group (CG) and metamizole group (MG). All calves were administered meloxicam (0.5 mg kg-1) intravenously (IV) 150 minutes before skin incision (SI). Animals were premedicated with xylazine (0.2 mg kg-1) intramuscularly 50 minutes before SI. Anaesthesia was induced with ketamine (2 mg kg-1) IV 30 minutes before SI and maintained with isoflurane in oxygen. MG calves were given metamizole (40 mg kg-1) IV 60 minutes before SI. CG calves were administered an equivalent volume of saline. Heart rate (HR) and mean arterial blood pressure (MAP) were recorded from 5 minutes before SI until the end of anaesthesia (60 minutes after SI). Blood samples for determination of the plasma cortisol concentration (PCC) were drawn 60 minutes before SI and at 5, 30, 60, 150, and 510 minutes after SI.In both groups, PCC increased during surgery and decreased after surgery. PCC was consistently lower in MG than in CG and was significantly (p = 0.0026) lower at 150 minutes after SI in the MG. Overall, the mean PCC in MG was 10.9 nmol L-1 lower than that in CG (p = 0.01). In both groups, HR decreased during anaesthesia, whereas MAP increased, albeit with no statistically significant (p > 0.05) differences between groups.Our study results suggest that a single preoperative dose of metamizole may have a positive impact on intra- and immediate postoperative analgesia by reducing PCC when used as an indicator of nociception.
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000154358 650_7 $$2Other$$acalf
000154358 650_7 $$2Other$$adipyrone
000154358 650_7 $$2Other$$ageneral anaesthesia
000154358 650_7 $$2Other$$ametamizole
000154358 650_7 $$2Other$$anociception
000154358 650_7 $$2Other$$apain management
000154358 650_2 $$2MeSH$$aAnimals
000154358 650_2 $$2MeSH$$aAnti-Inflammatory Agents, Non-Steroidal: therapeutic use
000154358 650_2 $$2MeSH$$aCattle
000154358 650_2 $$2MeSH$$aCattle Diseases: prevention & control
000154358 650_2 $$2MeSH$$aDipyrone: therapeutic use
000154358 650_2 $$2MeSH$$aFemale
000154358 650_2 $$2MeSH$$aHernia, Umbilical: surgery
000154358 650_2 $$2MeSH$$aHernia, Umbilical: veterinary
000154358 650_2 $$2MeSH$$aMale
000154358 650_2 $$2MeSH$$aPain, Postoperative: prevention & control
000154358 650_2 $$2MeSH$$aPain, Postoperative: veterinary
000154358 7001_ $$0P:(DE-HGF)0$$aBehrendt-Wippermann, Magdalena$$b1
000154358 7001_ $$0P:(DE-HGF)0$$aBaumgartner, Christine$$b2
000154358 7001_ $$0P:(DE-HGF)0$$aFeist, Melanie$$b3
000154358 7001_ $$0P:(DE-2719)9000925$$avon Thaden, Anne$$b4$$udzne
000154358 7001_ $$0P:(DE-HGF)0$$aRieger, Anna$$b5
000154358 7001_ $$0P:(DE-HGF)0$$aKnubben-Schweizer, Gabriela$$b6
000154358 773__ $$0PERI:(DE-600)2020582-X$$a10.1016/j.vaa.2019.10.013$$gVol. 47, no. 5, p. 710 - 719$$n5$$p710 - 719$$tVeterinary anaesthesia and analgesia$$v47$$x1467-2987$$y2020
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