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@ARTICLE{Metzner:154358,
      author       = {Metzner, Moritz and Behrendt-Wippermann, Magdalena and
                      Baumgartner, Christine and Feist, Melanie and von Thaden,
                      Anne and Rieger, Anna and Knubben-Schweizer, Gabriela},
      title        = {{U}se of metamizole as an additional analgesic during
                      umbilical surgery in calves.},
      journal      = {Veterinary anaesthesia and analgesia},
      volume       = {47},
      number       = {5},
      issn         = {1467-2987},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-00211},
      pages        = {710 - 719},
      year         = {2020},
      note         = {ISSN 1467-2987 not unique: **3 hits**.},
      abstract     = {To investigate the effect of metamizole on physiologic
                      variables in calves undergoing surgical extirpation of the
                      navel during anaesthesia using xylazine, ketamine and
                      isoflurane.Double-blind, randomized trial.A total of 26
                      calves.Calves with uncomplicated umbilical hernias and
                      otherwise clinically healthy were randomly allocated to one
                      of two groups: the control group (CG) and metamizole group
                      (MG). All calves were administered meloxicam (0.5 mg kg-1)
                      intravenously (IV) 150 minutes before skin incision (SI).
                      Animals were premedicated with xylazine (0.2 mg kg-1)
                      intramuscularly 50 minutes before SI. Anaesthesia was
                      induced with ketamine (2 mg kg-1) IV 30 minutes before SI
                      and maintained with isoflurane in oxygen. MG calves were
                      given metamizole (40 mg kg-1) IV 60 minutes before SI. CG
                      calves were administered an equivalent volume of saline.
                      Heart rate (HR) and mean arterial blood pressure (MAP) were
                      recorded from 5 minutes before SI until the end of
                      anaesthesia (60 minutes after SI). Blood samples for
                      determination of the plasma cortisol concentration (PCC)
                      were drawn 60 minutes before SI and at 5, 30, 60, 150, and
                      510 minutes after SI.In both groups, PCC increased during
                      surgery and decreased after surgery. PCC was consistently
                      lower in MG than in CG and was significantly (p = 0.0026)
                      lower at 150 minutes after SI in the MG. Overall, the mean
                      PCC in MG was 10.9 nmol L-1 lower than that in CG (p =
                      0.01). In both groups, HR decreased during anaesthesia,
                      whereas MAP increased, albeit with no statistically
                      significant (p > 0.05) differences between groups.Our study
                      results suggest that a single preoperative dose of
                      metamizole may have a positive impact on intra- and
                      immediate postoperative analgesia by reducing PCC when used
                      as an indicator of nociception.},
      keywords     = {Animals / Anti-Inflammatory Agents, Non-Steroidal:
                      therapeutic use / Cattle / Cattle Diseases: prevention $\&$
                      control / Dipyrone: therapeutic use / Female / Hernia,
                      Umbilical: surgery / Hernia, Umbilical: veterinary / Male /
                      Pain, Postoperative: prevention $\&$ control / Pain,
                      Postoperative: veterinary / calf (Other) / dipyrone (Other)
                      / general anaesthesia (Other) / metamizole (Other) /
                      nociception (Other) / pain management (Other)},
      cin          = {Animal Facility (Mouse) München},
      ddc          = {630},
      cid          = {I:(DE-2719)1140012},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32792274},
      doi          = {10.1016/j.vaa.2019.10.013},
      url          = {https://pub.dzne.de/record/154358},
}