000154366 001__ 154366
000154366 005__ 20240222132624.0
000154366 0247_ $$2doi$$a10.1016/j.cell.2020.08.001
000154366 0247_ $$2pmid$$apmid:32810438
000154366 0247_ $$2pmc$$apmc:PMC7405822
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000154366 0247_ $$2ISSN$$a1097-4172
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000154366 037__ $$aDZNE-2021-00219
000154366 041__ $$aEnglish
000154366 082__ $$a610
000154366 1001_ $$0P:(DE-HGF)0$$aSchulte-Schrepping, Jonas$$b0
000154366 245__ $$aSevere COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
000154366 260__ $$aNew York, NY$$bElsevier$$c2020
000154366 3367_ $$2DRIVER$$aarticle
000154366 3367_ $$2DataCite$$aOutput Types/Journal article
000154366 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1708604722_31174
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000154366 520__ $$aCoronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
000154366 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000154366 650_7 $$2Other$$aCOVID-19
000154366 650_7 $$2Other$$aSARS-CoV-2
000154366 650_7 $$2Other$$adysfunctional neutrophils
000154366 650_7 $$2Other$$aemergency myelopoiesis
000154366 650_7 $$2Other$$aimmune profiling
000154366 650_7 $$2Other$$amass cytometry
000154366 650_7 $$2Other$$amonocytes
000154366 650_7 $$2Other$$aneutrophils
000154366 650_7 $$2Other$$ascRNA-seq
000154366 650_7 $$2NLM Chemicals$$aCD11 Antigens
000154366 650_7 $$2NLM Chemicals$$aHLA-DR Antigens
000154366 650_7 $$2NLM Chemicals$$aProteome
000154366 650_2 $$2MeSH$$aAdult
000154366 650_2 $$2MeSH$$aAged
000154366 650_2 $$2MeSH$$aCD11 Antigens: genetics
000154366 650_2 $$2MeSH$$aCD11 Antigens: metabolism
000154366 650_2 $$2MeSH$$aCOVID-19
000154366 650_2 $$2MeSH$$aCells, Cultured
000154366 650_2 $$2MeSH$$aCoronavirus Infections: blood
000154366 650_2 $$2MeSH$$aCoronavirus Infections: immunology
000154366 650_2 $$2MeSH$$aCoronavirus Infections: pathology
000154366 650_2 $$2MeSH$$aFemale
000154366 650_2 $$2MeSH$$aHLA-DR Antigens: genetics
000154366 650_2 $$2MeSH$$aHLA-DR Antigens: metabolism
000154366 650_2 $$2MeSH$$aHumans
000154366 650_2 $$2MeSH$$aMale
000154366 650_2 $$2MeSH$$aMiddle Aged
000154366 650_2 $$2MeSH$$aMyeloid Cells: cytology
000154366 650_2 $$2MeSH$$aMyeloid Cells: immunology
000154366 650_2 $$2MeSH$$aMyelopoiesis
000154366 650_2 $$2MeSH$$aPandemics
000154366 650_2 $$2MeSH$$aPneumonia, Viral: blood
000154366 650_2 $$2MeSH$$aPneumonia, Viral: immunology
000154366 650_2 $$2MeSH$$aPneumonia, Viral: pathology
000154366 650_2 $$2MeSH$$aProteome: genetics
000154366 650_2 $$2MeSH$$aProteome: metabolism
000154366 650_2 $$2MeSH$$aProteomics
000154366 650_2 $$2MeSH$$aSingle-Cell Analysis
000154366 7001_ $$0P:(DE-HGF)0$$aReusch, Nico$$b1
000154366 7001_ $$0P:(DE-HGF)0$$aPaclik, Daniela$$b2
000154366 7001_ $$0P:(DE-HGF)0$$aBaßler, Kevin$$b3
000154366 7001_ $$aSchlickeiser, Stephan$$b4
000154366 7001_ $$aZhang, Bowen$$b5
000154366 7001_ $$aKrämer, Benjamin$$b6
000154366 7001_ $$aKrammer, Tobias$$b7
000154366 7001_ $$aBrumhard, Sophia$$b8
000154366 7001_ $$aBonaguro, Lorenzo$$b9
000154366 7001_ $$0P:(DE-2719)9000846$$aDe Domenico, Elena$$b10$$udzne
000154366 7001_ $$0P:(DE-HGF)0$$aWendisch, Daniel$$b11
000154366 7001_ $$aGrasshoff, Martin$$b12
000154366 7001_ $$aKapellos, Theodore S$$b13
000154366 7001_ $$aBeckstette, Michael$$b14
000154366 7001_ $$aPecht, Tal$$b15
000154366 7001_ $$0P:(DE-2719)2812564$$aSaglam, Adem$$b16$$udzne
000154366 7001_ $$aDietrich, Oliver$$b17
000154366 7001_ $$aMei, Henrik E$$b18
000154366 7001_ $$aSchulz, Axel R$$b19
000154366 7001_ $$aConrad, Claudia$$b20
000154366 7001_ $$aKunkel, Désirée$$b21
000154366 7001_ $$aVafadarnejad, Ehsan$$b22
000154366 7001_ $$aXu, Cheng-Jian$$b23
000154366 7001_ $$aHorne, Arik$$b24
000154366 7001_ $$0P:(DE-HGF)0$$aHerbert, Miriam$$b25
000154366 7001_ $$0P:(DE-2719)2812302$$aDrews, Anna$$b26$$udzne
000154366 7001_ $$aThibeault, Charlotte$$b27
000154366 7001_ $$aPfeiffer, Moritz$$b28
000154366 7001_ $$aHippenstiel, Stefan$$b29
000154366 7001_ $$aHocke, Andreas$$b30
000154366 7001_ $$aMüller-Redetzky, Holger$$b31
000154366 7001_ $$aHeim, Katrin-Moira$$b32
000154366 7001_ $$aMachleidt, Felix$$b33
000154366 7001_ $$aUhrig, Alexander$$b34
000154366 7001_ $$aBosquillon de Jarcy, Laure$$b35
000154366 7001_ $$aJürgens, Linda$$b36
000154366 7001_ $$aStegemann, Miriam$$b37
000154366 7001_ $$aGlösenkamp, Christoph R$$b38
000154366 7001_ $$aVolk, Hans-Dieter$$b39
000154366 7001_ $$aGoffinet, Christine$$b40
000154366 7001_ $$aLandthaler, Markus$$b41
000154366 7001_ $$aWyler, Emanuel$$b42
000154366 7001_ $$aGeorg, Philipp$$b43
000154366 7001_ $$aSchneider, Maria$$b44
000154366 7001_ $$aDang-Heine, Chantip$$b45
000154366 7001_ $$aNeuwinger, Nick$$b46
000154366 7001_ $$aKappert, Kai$$b47
000154366 7001_ $$aTauber, Rudolf$$b48
000154366 7001_ $$0P:(DE-HGF)0$$aCorman, Victor$$b49
000154366 7001_ $$aRaabe, Jan$$b50
000154366 7001_ $$aKaiser, Kim Melanie$$b51
000154366 7001_ $$aVinh, Michael To$$b52
000154366 7001_ $$aRieke, Gereon$$b53
000154366 7001_ $$aMeisel, Christian$$b54
000154366 7001_ $$0P:(DE-HGF)0$$aUlas, Thomas$$b55
000154366 7001_ $$0P:(DE-HGF)0$$aBecker, Matthias$$b56
000154366 7001_ $$aGeffers, Robert$$b57
000154366 7001_ $$aWitzenrath, Martin$$b58
000154366 7001_ $$aDrosten, Christian$$b59
000154366 7001_ $$aSuttorp, Norbert$$b60
000154366 7001_ $$avon Kalle, Christof$$b61
000154366 7001_ $$aKurth, Florian$$b62
000154366 7001_ $$0P:(DE-HGF)0$$aHändler, Kristian$$b63
000154366 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b64$$udzne
000154366 7001_ $$0P:(DE-HGF)0$$aAschenbrenner, Anna C$$b65
000154366 7001_ $$aLi, Yang$$b66
000154366 7001_ $$aNattermann, Jacob$$b67
000154366 7001_ $$aSawitzki, Birgit$$b68
000154366 7001_ $$aSaliba, Antoine-Emmanuel$$b69
000154366 7001_ $$aSander, Leif Erik$$b70
000154366 7001_ $$0P:(DE-HGF)0$$aInitiative, Deutsche COVID-19 OMICS$$b71$$eCollaboration Author
000154366 7001_ $$aAngelov, Angel$$b72
000154366 7001_ $$aBals, Robert$$b73
000154366 7001_ $$aBartholomäus, Alexander$$b74
000154366 7001_ $$aBecker, Anke$$b75
000154366 7001_ $$aBezdan, Daniela$$b76
000154366 7001_ $$aBonifacio, Ezio$$b77
000154366 7001_ $$aBork, Peer$$b78
000154366 7001_ $$aClavel, Thomas$$b79
000154366 7001_ $$aColome-Tatche, Maria$$b80
000154366 7001_ $$aDiefenbach, Andreas$$b81
000154366 7001_ $$aDilthey, Alexander$$b82
000154366 7001_ $$aFischer, Nicole$$b83
000154366 7001_ $$aFörstner, Konrad$$b84
000154366 7001_ $$aFrick, Julia-Stefanie$$b85
000154366 7001_ $$aGagneur, Julien$$b86
000154366 7001_ $$aGoesmann, Alexander$$b87
000154366 7001_ $$aHain, Torsten$$b88
000154366 7001_ $$aHummel, Michael$$b89
000154366 7001_ $$aJanssen, Stefan$$b90
000154366 7001_ $$aKalinowski, Jörn$$b91
000154366 7001_ $$aKallies, René$$b92
000154366 7001_ $$aKehr, Birte$$b93
000154366 7001_ $$aKeller, Andreas$$b94
000154366 7001_ $$aKim-Hellmuth, Sarah$$b95
000154366 7001_ $$aKlein, Christoph$$b96
000154366 7001_ $$aKohlbacher, Oliver$$b97
000154366 7001_ $$aKorbel, Jan O$$b98
000154366 7001_ $$aKurth, Ingo$$b99
000154366 7001_ $$aLandthaler, Markus$$b100
000154366 7001_ $$aLi, Yang$$b101
000154366 7001_ $$aLudwig, Kerstin$$b102
000154366 7001_ $$aMakarewicz, Oliwia$$b103
000154366 7001_ $$aMarz, Manja$$b104
000154366 7001_ $$aMcHardy, Alice$$b105
000154366 7001_ $$aMertes, Christian$$b106
000154366 7001_ $$0P:(DE-2719)9000400$$aNöthen, Markus$$b107$$udzne
000154366 7001_ $$aNürnberg, Peter$$b108
000154366 7001_ $$aOhler, Uwe$$b109
000154366 7001_ $$aOssowski, Stephan$$b110
000154366 7001_ $$aOvermann, Jörg$$b111
000154366 7001_ $$aPeter, Silke$$b112
000154366 7001_ $$aPfeffer, Klaus$$b113
000154366 7001_ $$aPoetsch, Anna R$$b114
000154366 7001_ $$aPühler, Alfred$$b115
000154366 7001_ $$aRajewsky, Nikolaus$$b116
000154366 7001_ $$aRalser, Markus$$b117
000154366 7001_ $$aRieß, Olaf$$b118
000154366 7001_ $$aRipke, Stephan$$b119
000154366 7001_ $$aNunes da Rocha, Ulisses$$b120
000154366 7001_ $$aRosenstiel, Philip$$b121
000154366 7001_ $$aSaliba, Antoine-Emmanuel$$b122
000154366 7001_ $$aSander, Leif Erik$$b123
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000154366 7001_ $$aSczyrba, Alexander$$b127
000154366 7001_ $$aStegle, Oliver$$b128
000154366 7001_ $$aStoye, Jens$$b129
000154366 7001_ $$aTheis, Fabian$$b130
000154366 7001_ $$aVehreschild, Janne$$b131
000154366 7001_ $$aVogel, Jörg$$b132
000154366 7001_ $$avon Kleist, Max$$b133
000154366 7001_ $$aWalker, Andreas$$b134
000154366 7001_ $$aWalter, Jörn$$b135
000154366 7001_ $$aWieczorek, Dagmar$$b136
000154366 7001_ $$aZiebuhr, John$$b137
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