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@ARTICLE{SchulteSchrepping:154366,
      author       = {Schulte-Schrepping, Jonas and Reusch, Nico and Paclik,
                      Daniela and Baßler, Kevin and Schlickeiser, Stephan and
                      Zhang, Bowen and Krämer, Benjamin and Krammer, Tobias and
                      Brumhard, Sophia and Bonaguro, Lorenzo and De Domenico,
                      Elena and Wendisch, Daniel and Grasshoff, Martin and
                      Kapellos, Theodore S and Beckstette, Michael and Pecht, Tal
                      and Saglam, Adem and Dietrich, Oliver and Mei, Henrik E and
                      Schulz, Axel R and Conrad, Claudia and Kunkel, Désirée and
                      Vafadarnejad, Ehsan and Xu, Cheng-Jian and Horne, Arik and
                      Herbert, Miriam and Drews, Anna and Thibeault, Charlotte and
                      Pfeiffer, Moritz and Hippenstiel, Stefan and Hocke, Andreas
                      and Müller-Redetzky, Holger and Heim, Katrin-Moira and
                      Machleidt, Felix and Uhrig, Alexander and Bosquillon de
                      Jarcy, Laure and Jürgens, Linda and Stegemann, Miriam and
                      Glösenkamp, Christoph R and Volk, Hans-Dieter and Goffinet,
                      Christine and Landthaler, Markus and Wyler, Emanuel and
                      Georg, Philipp and Schneider, Maria and Dang-Heine, Chantip
                      and Neuwinger, Nick and Kappert, Kai and Tauber, Rudolf and
                      Corman, Victor and Raabe, Jan and Kaiser, Kim Melanie and
                      Vinh, Michael To and Rieke, Gereon and Meisel, Christian and
                      Ulas, Thomas and Becker, Matthias and Geffers, Robert and
                      Witzenrath, Martin and Drosten, Christian and Suttorp,
                      Norbert and von Kalle, Christof and Kurth, Florian and
                      Händler, Kristian and Schultze, Joachim L and
                      Aschenbrenner, Anna C and Li, Yang and Nattermann, Jacob and
                      Sawitzki, Birgit and Saliba, Antoine-Emmanuel and Sander,
                      Leif Erik and Angelov, Angel and Bals, Robert and
                      Bartholomäus, Alexander and Becker, Anke and Bezdan,
                      Daniela and Bonifacio, Ezio and Bork, Peer and Clavel,
                      Thomas and Colome-Tatche, Maria and Diefenbach, Andreas and
                      Dilthey, Alexander and Fischer, Nicole and Förstner, Konrad
                      and Frick, Julia-Stefanie and Gagneur, Julien and Goesmann,
                      Alexander and Hain, Torsten and Hummel, Michael and Janssen,
                      Stefan and Kalinowski, Jörn and Kallies, René and Kehr,
                      Birte and Keller, Andreas and Kim-Hellmuth, Sarah and Klein,
                      Christoph and Kohlbacher, Oliver and Korbel, Jan O and
                      Kurth, Ingo and Landthaler, Markus and Li, Yang and Ludwig,
                      Kerstin and Makarewicz, Oliwia and Marz, Manja and McHardy,
                      Alice and Mertes, Christian and Nöthen, Markus and
                      Nürnberg, Peter and Ohler, Uwe and Ossowski, Stephan and
                      Overmann, Jörg and Peter, Silke and Pfeffer, Klaus and
                      Poetsch, Anna R and Pühler, Alfred and Rajewsky, Nikolaus
                      and Ralser, Markus and Rieß, Olaf and Ripke, Stephan and
                      Nunes da Rocha, Ulisses and Rosenstiel, Philip and Saliba,
                      Antoine-Emmanuel and Sander, Leif Erik and Sawitzki, Birgit
                      and Schiffer, Philipp and Schulte, Eva-Christina and
                      Sczyrba, Alexander and Stegle, Oliver and Stoye, Jens and
                      Theis, Fabian and Vehreschild, Janne and Vogel, Jörg and
                      von Kleist, Max and Walker, Andreas and Walter, Jörn and
                      Wieczorek, Dagmar and Ziebuhr, John},
      collaboration = {Initiative, Deutsche COVID-19 OMICS},
      title        = {{S}evere {COVID}-19 {I}s {M}arked by a {D}ysregulated
                      {M}yeloid {C}ell {C}ompartment.},
      journal      = {Cell},
      volume       = {182},
      number       = {6},
      issn         = {0092-8674},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-00219},
      pages        = {1419 - 1440.e23},
      year         = {2020},
      note         = {ISSN 0092-8674 not unique: **3 hits**.},
      abstract     = {Coronavirus disease 2019 (COVID-19) is a mild to moderate
                      respiratory tract infection, however, a subset of patients
                      progress to severe disease and respiratory failure. The
                      mechanism of protective immunity in mild forms and the
                      pathogenesis of severe COVID-19 associated with increased
                      neutrophil counts and dysregulated immune responses remain
                      unclear. In a dual-center, two-cohort study, we combined
                      single-cell RNA-sequencing and single-cell proteomics of
                      whole-blood and peripheral-blood mononuclear cells to
                      determine changes in immune cell composition and activation
                      in mild versus severe COVID-19 (242 samples from 109
                      individuals) over time. HLA-DRhiCD11chi inflammatory
                      monocytes with an interferon-stimulated gene signature were
                      elevated in mild COVID-19. Severe COVID-19 was marked by
                      occurrence of neutrophil precursors, as evidence of
                      emergency myelopoiesis, dysfunctional mature neutrophils,
                      and HLA-DRlo monocytes. Our study provides detailed insights
                      into the systemic immune response to SARS-CoV-2 infection
                      and reveals profound alterations in the myeloid cell
                      compartment associated with severe COVID-19.},
      keywords     = {Adult / Aged / CD11 Antigens: genetics / CD11 Antigens:
                      metabolism / COVID-19 / Cells, Cultured / Coronavirus
                      Infections: blood / Coronavirus Infections: immunology /
                      Coronavirus Infections: pathology / Female / HLA-DR
                      Antigens: genetics / HLA-DR Antigens: metabolism / Humans /
                      Male / Middle Aged / Myeloid Cells: cytology / Myeloid
                      Cells: immunology / Myelopoiesis / Pandemics / Pneumonia,
                      Viral: blood / Pneumonia, Viral: immunology / Pneumonia,
                      Viral: pathology / Proteome: genetics / Proteome: metabolism
                      / Proteomics / Single-Cell Analysis / COVID-19 (Other) /
                      SARS-CoV-2 (Other) / dysfunctional neutrophils (Other) /
                      emergency myelopoiesis (Other) / immune profiling (Other) /
                      mass cytometry (Other) / monocytes (Other) / neutrophils
                      (Other) / scRNA-seq (Other) / CD11 Antigens (NLM Chemicals)
                      / HLA-DR Antigens (NLM Chemicals) / Proteome (NLM
                      Chemicals)},
      cin          = {Schultze - PRECISE},
      ddc          = {610},
      cid          = {I:(DE-2719)1013031},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32810438},
      pmc          = {pmc:PMC7405822},
      doi          = {10.1016/j.cell.2020.08.001},
      url          = {https://pub.dzne.de/record/154366},
}