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| 001 | 154366 | ||
| 005 | 20240222132624.0 | ||
| 024 | 7 | _ | |a 10.1016/j.cell.2020.08.001 |2 doi |
| 024 | 7 | _ | |a pmid:32810438 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC7405822 |2 pmc |
| 024 | 7 | _ | |a 0092-8674 |2 ISSN |
| 024 | 7 | _ | |a 1097-4172 |2 ISSN |
| 024 | 7 | _ | |a altmetric:87202932 |2 altmetric |
| 037 | _ | _ | |a DZNE-2021-00219 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Schulte-Schrepping, Jonas |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. |
| 260 | _ | _ | |a New York, NY |c 2020 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1708604722_31174 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a ISSN 0092-8674 not unique: **3 hits**. |
| 520 | _ | _ | |a Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a COVID-19 |2 Other |
| 650 | _ | 7 | |a SARS-CoV-2 |2 Other |
| 650 | _ | 7 | |a dysfunctional neutrophils |2 Other |
| 650 | _ | 7 | |a emergency myelopoiesis |2 Other |
| 650 | _ | 7 | |a immune profiling |2 Other |
| 650 | _ | 7 | |a mass cytometry |2 Other |
| 650 | _ | 7 | |a monocytes |2 Other |
| 650 | _ | 7 | |a neutrophils |2 Other |
| 650 | _ | 7 | |a scRNA-seq |2 Other |
| 650 | _ | 7 | |a CD11 Antigens |2 NLM Chemicals |
| 650 | _ | 7 | |a HLA-DR Antigens |2 NLM Chemicals |
| 650 | _ | 7 | |a Proteome |2 NLM Chemicals |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a CD11 Antigens: genetics |2 MeSH |
| 650 | _ | 2 | |a CD11 Antigens: metabolism |2 MeSH |
| 650 | _ | 2 | |a COVID-19 |2 MeSH |
| 650 | _ | 2 | |a Cells, Cultured |2 MeSH |
| 650 | _ | 2 | |a Coronavirus Infections: blood |2 MeSH |
| 650 | _ | 2 | |a Coronavirus Infections: immunology |2 MeSH |
| 650 | _ | 2 | |a Coronavirus Infections: pathology |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a HLA-DR Antigens: genetics |2 MeSH |
| 650 | _ | 2 | |a HLA-DR Antigens: metabolism |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Myeloid Cells: cytology |2 MeSH |
| 650 | _ | 2 | |a Myeloid Cells: immunology |2 MeSH |
| 650 | _ | 2 | |a Myelopoiesis |2 MeSH |
| 650 | _ | 2 | |a Pandemics |2 MeSH |
| 650 | _ | 2 | |a Pneumonia, Viral: blood |2 MeSH |
| 650 | _ | 2 | |a Pneumonia, Viral: immunology |2 MeSH |
| 650 | _ | 2 | |a Pneumonia, Viral: pathology |2 MeSH |
| 650 | _ | 2 | |a Proteome: genetics |2 MeSH |
| 650 | _ | 2 | |a Proteome: metabolism |2 MeSH |
| 650 | _ | 2 | |a Proteomics |2 MeSH |
| 650 | _ | 2 | |a Single-Cell Analysis |2 MeSH |
| 700 | 1 | _ | |a Reusch, Nico |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Paclik, Daniela |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Baßler, Kevin |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Schlickeiser, Stephan |b 4 |
| 700 | 1 | _ | |a Zhang, Bowen |b 5 |
| 700 | 1 | _ | |a Krämer, Benjamin |b 6 |
| 700 | 1 | _ | |a Krammer, Tobias |b 7 |
| 700 | 1 | _ | |a Brumhard, Sophia |b 8 |
| 700 | 1 | _ | |a Bonaguro, Lorenzo |b 9 |
| 700 | 1 | _ | |a De Domenico, Elena |0 P:(DE-2719)9000846 |b 10 |u dzne |
| 700 | 1 | _ | |a Wendisch, Daniel |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Grasshoff, Martin |b 12 |
| 700 | 1 | _ | |a Kapellos, Theodore S |b 13 |
| 700 | 1 | _ | |a Beckstette, Michael |b 14 |
| 700 | 1 | _ | |a Pecht, Tal |b 15 |
| 700 | 1 | _ | |a Saglam, Adem |0 P:(DE-2719)2812564 |b 16 |u dzne |
| 700 | 1 | _ | |a Dietrich, Oliver |b 17 |
| 700 | 1 | _ | |a Mei, Henrik E |b 18 |
| 700 | 1 | _ | |a Schulz, Axel R |b 19 |
| 700 | 1 | _ | |a Conrad, Claudia |b 20 |
| 700 | 1 | _ | |a Kunkel, Désirée |b 21 |
| 700 | 1 | _ | |a Vafadarnejad, Ehsan |b 22 |
| 700 | 1 | _ | |a Xu, Cheng-Jian |b 23 |
| 700 | 1 | _ | |a Horne, Arik |b 24 |
| 700 | 1 | _ | |a Herbert, Miriam |0 P:(DE-HGF)0 |b 25 |
| 700 | 1 | _ | |a Drews, Anna |0 P:(DE-2719)2812302 |b 26 |u dzne |
| 700 | 1 | _ | |a Thibeault, Charlotte |b 27 |
| 700 | 1 | _ | |a Pfeiffer, Moritz |b 28 |
| 700 | 1 | _ | |a Hippenstiel, Stefan |b 29 |
| 700 | 1 | _ | |a Hocke, Andreas |b 30 |
| 700 | 1 | _ | |a Müller-Redetzky, Holger |b 31 |
| 700 | 1 | _ | |a Heim, Katrin-Moira |b 32 |
| 700 | 1 | _ | |a Machleidt, Felix |b 33 |
| 700 | 1 | _ | |a Uhrig, Alexander |b 34 |
| 700 | 1 | _ | |a Bosquillon de Jarcy, Laure |b 35 |
| 700 | 1 | _ | |a Jürgens, Linda |b 36 |
| 700 | 1 | _ | |a Stegemann, Miriam |b 37 |
| 700 | 1 | _ | |a Glösenkamp, Christoph R |b 38 |
| 700 | 1 | _ | |a Volk, Hans-Dieter |b 39 |
| 700 | 1 | _ | |a Goffinet, Christine |b 40 |
| 700 | 1 | _ | |a Landthaler, Markus |b 41 |
| 700 | 1 | _ | |a Wyler, Emanuel |b 42 |
| 700 | 1 | _ | |a Georg, Philipp |b 43 |
| 700 | 1 | _ | |a Schneider, Maria |b 44 |
| 700 | 1 | _ | |a Dang-Heine, Chantip |b 45 |
| 700 | 1 | _ | |a Neuwinger, Nick |b 46 |
| 700 | 1 | _ | |a Kappert, Kai |b 47 |
| 700 | 1 | _ | |a Tauber, Rudolf |b 48 |
| 700 | 1 | _ | |a Corman, Victor |0 P:(DE-HGF)0 |b 49 |
| 700 | 1 | _ | |a Raabe, Jan |b 50 |
| 700 | 1 | _ | |a Kaiser, Kim Melanie |b 51 |
| 700 | 1 | _ | |a Vinh, Michael To |b 52 |
| 700 | 1 | _ | |a Rieke, Gereon |b 53 |
| 700 | 1 | _ | |a Meisel, Christian |b 54 |
| 700 | 1 | _ | |a Ulas, Thomas |0 P:(DE-HGF)0 |b 55 |
| 700 | 1 | _ | |a Becker, Matthias |0 P:(DE-HGF)0 |b 56 |
| 700 | 1 | _ | |a Geffers, Robert |b 57 |
| 700 | 1 | _ | |a Witzenrath, Martin |b 58 |
| 700 | 1 | _ | |a Drosten, Christian |b 59 |
| 700 | 1 | _ | |a Suttorp, Norbert |b 60 |
| 700 | 1 | _ | |a von Kalle, Christof |b 61 |
| 700 | 1 | _ | |a Kurth, Florian |b 62 |
| 700 | 1 | _ | |a Händler, Kristian |0 P:(DE-HGF)0 |b 63 |
| 700 | 1 | _ | |a Schultze, Joachim L |0 P:(DE-2719)2811660 |b 64 |u dzne |
| 700 | 1 | _ | |a Aschenbrenner, Anna C |0 P:(DE-HGF)0 |b 65 |
| 700 | 1 | _ | |a Li, Yang |b 66 |
| 700 | 1 | _ | |a Nattermann, Jacob |b 67 |
| 700 | 1 | _ | |a Sawitzki, Birgit |b 68 |
| 700 | 1 | _ | |a Saliba, Antoine-Emmanuel |b 69 |
| 700 | 1 | _ | |a Sander, Leif Erik |b 70 |
| 700 | 1 | _ | |a Initiative, Deutsche COVID-19 OMICS |0 P:(DE-HGF)0 |b 71 |e Collaboration Author |
| 700 | 1 | _ | |a Angelov, Angel |b 72 |
| 700 | 1 | _ | |a Bals, Robert |b 73 |
| 700 | 1 | _ | |a Bartholomäus, Alexander |b 74 |
| 700 | 1 | _ | |a Becker, Anke |b 75 |
| 700 | 1 | _ | |a Bezdan, Daniela |b 76 |
| 700 | 1 | _ | |a Bonifacio, Ezio |b 77 |
| 700 | 1 | _ | |a Bork, Peer |b 78 |
| 700 | 1 | _ | |a Clavel, Thomas |b 79 |
| 700 | 1 | _ | |a Colome-Tatche, Maria |b 80 |
| 700 | 1 | _ | |a Diefenbach, Andreas |b 81 |
| 700 | 1 | _ | |a Dilthey, Alexander |b 82 |
| 700 | 1 | _ | |a Fischer, Nicole |b 83 |
| 700 | 1 | _ | |a Förstner, Konrad |b 84 |
| 700 | 1 | _ | |a Frick, Julia-Stefanie |b 85 |
| 700 | 1 | _ | |a Gagneur, Julien |b 86 |
| 700 | 1 | _ | |a Goesmann, Alexander |b 87 |
| 700 | 1 | _ | |a Hain, Torsten |b 88 |
| 700 | 1 | _ | |a Hummel, Michael |b 89 |
| 700 | 1 | _ | |a Janssen, Stefan |b 90 |
| 700 | 1 | _ | |a Kalinowski, Jörn |b 91 |
| 700 | 1 | _ | |a Kallies, René |b 92 |
| 700 | 1 | _ | |a Kehr, Birte |b 93 |
| 700 | 1 | _ | |a Keller, Andreas |b 94 |
| 700 | 1 | _ | |a Kim-Hellmuth, Sarah |b 95 |
| 700 | 1 | _ | |a Klein, Christoph |b 96 |
| 700 | 1 | _ | |a Kohlbacher, Oliver |b 97 |
| 700 | 1 | _ | |a Korbel, Jan O |b 98 |
| 700 | 1 | _ | |a Kurth, Ingo |b 99 |
| 700 | 1 | _ | |a Landthaler, Markus |b 100 |
| 700 | 1 | _ | |a Li, Yang |b 101 |
| 700 | 1 | _ | |a Ludwig, Kerstin |b 102 |
| 700 | 1 | _ | |a Makarewicz, Oliwia |b 103 |
| 700 | 1 | _ | |a Marz, Manja |b 104 |
| 700 | 1 | _ | |a McHardy, Alice |b 105 |
| 700 | 1 | _ | |a Mertes, Christian |b 106 |
| 700 | 1 | _ | |a Nöthen, Markus |0 P:(DE-2719)9000400 |b 107 |u dzne |
| 700 | 1 | _ | |a Nürnberg, Peter |b 108 |
| 700 | 1 | _ | |a Ohler, Uwe |b 109 |
| 700 | 1 | _ | |a Ossowski, Stephan |b 110 |
| 700 | 1 | _ | |a Overmann, Jörg |b 111 |
| 700 | 1 | _ | |a Peter, Silke |b 112 |
| 700 | 1 | _ | |a Pfeffer, Klaus |b 113 |
| 700 | 1 | _ | |a Poetsch, Anna R |b 114 |
| 700 | 1 | _ | |a Pühler, Alfred |b 115 |
| 700 | 1 | _ | |a Rajewsky, Nikolaus |b 116 |
| 700 | 1 | _ | |a Ralser, Markus |b 117 |
| 700 | 1 | _ | |a Rieß, Olaf |b 118 |
| 700 | 1 | _ | |a Ripke, Stephan |b 119 |
| 700 | 1 | _ | |a Nunes da Rocha, Ulisses |b 120 |
| 700 | 1 | _ | |a Rosenstiel, Philip |b 121 |
| 700 | 1 | _ | |a Saliba, Antoine-Emmanuel |b 122 |
| 700 | 1 | _ | |a Sander, Leif Erik |b 123 |
| 700 | 1 | _ | |a Sawitzki, Birgit |b 124 |
| 700 | 1 | _ | |a Schiffer, Philipp |b 125 |
| 700 | 1 | _ | |a Schulte, Eva-Christina |b 126 |
| 700 | 1 | _ | |a Sczyrba, Alexander |b 127 |
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| 700 | 1 | _ | |a Walter, Jörn |b 135 |
| 700 | 1 | _ | |a Wieczorek, Dagmar |b 136 |
| 700 | 1 | _ | |a Ziebuhr, John |b 137 |
| 773 | _ | _ | |a 10.1016/j.cell.2020.08.001 |g Vol. 182, no. 6, p. 1419 - 1440.e23 |0 PERI:(DE-600)2001951-8 |n 6 |p 1419 - 1440.e23 |t Cell |v 182 |y 2020 |x 0092-8674 |
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