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@ARTICLE{Teipel:154369,
author = {Teipel, Stefan J and Fritz, H-Christian and Grothe, Michel
and Weiner, Michael and Aisen, Paul and Petersen, Ronald and
Jack, Clifford R. and Jagust, William and Trojanowki, John
Q. and Toga, Arthur W. and Beckett, Laurel and Green, Robert
C. and Saykin, Andrew J. and Morris, John and Liu, Enchi and
Green, Robert C. and Montine, Tom and Petersen, Ronald and
Aisen, Paul and Gamst, Anthony and Thomas, Ronald G. and
Donohue, Michael and Walter, Sarah and Gessert, Devon and
Sather, Tamie and Beckett, Laurel and Harvey, Danielle and
Gamst, Anthony and Donohue, Michael and Kornak, John and
Jack, Clifford R. and Dale, Anders and Bernstein, Matthew
and Felmlee, Joel and Fox, Nick and Thompson, Paul and
Schuff, Norbert and Alexander, Gene and DeCarli, Charles and
Jagust, William and Bandy, Dan and Koeppe, Robert A. and
Foster, Norm and Reiman, Eric M. and Chen, Kewei and Mathis,
Chet and Morris, John and Cairns, Nigel J. and
Taylor-Reinwald, Lisa and Trojanowki, J. Q. and Shaw, Les
and Lee, Virginia M Y and Korecka, Magdalena and Toga,
Arthur W. and Crawford, Karen and Neu, Scott and Saykin,
Andrew J. and Foroud, Tatiana M. and Potkin, Steven and
Shen, Li and Kachaturian, Zaven and Frank, Richard and
Snyder, Peter J. and Molchan, Susan and Kaye, Jeffrey and
Quinn, Joseph and Lind, Betty and Dolen, Sara and Schneider,
Lon S. and Pawluczyk, Sonia and Spann, Bryan M. and Brewer,
James and Vanderswag, Helen and Heidebrink, Judith L. and
Lord, Joanne L. and Petersen, Ronald and Johnson, Kris and
Doody, Rachelle S. and Villanueva-Meyer, Javier and
Chowdhury, Munir and Stern, Yaakov and Honig, Lawrence S.
and Bell, Karen L. and Morris, John C. and Ances, Beau and
Carroll, Maria and Leon, Sue and Mintun, Mark A. and
Schneider, Stacy and Marson, Daniel and Griffith, Randall
and Clark, David and Grossman, Hillel and Mitsis, Effie and
Romirowsky, Aliza and deToledo-Morrell, Leyla and Shah, Raj
C. and Duara, Ranjan and Varon, Daniel and Roberts, Peggy
and Albert, Marilyn and Onyike, Chiadi and Kielb, Stephanie
and Rusinek, Henry and de Leon, Mony J and Glodzik, Lidia
and De Santi, Susan and Doraiswamy, P. Murali and Petrella,
Jeffrey R. and Coleman, R. Edward and Arnold, Steven E. and
Karlawish, Jason H. and Wolk, David and Smith, Charles D.
and Jicha, Greg and Hardy, Peter and Lopez, Oscar L. and
Oakley, MaryAnn and Simpson, Donna M. and Porsteinsson,
Anton P. and Goldstein, Bonnie S. and Martin, Kim and
Makino, Kelly M. and Ismail, M. Saleem and Brand, Connie and
Mulnard, Ruth A. and Thai, Gaby and Mc-Adams-Ortiz,
Catherine and Womack, Kyle and Mathews, Dana and Quiceno,
Mary and Diaz-Arrastia, Ramon and King, Richard and Weiner,
Myron and Martin-Cook, Kristen and DeVous, Michael and
Levey, Allan I. and Lah, James J. and Cellar, Janet S. and
Burns, Jeffrey M. and Anderson, Heather S. and Swerdlow,
Russell H. and Apostolova, Liana and Lu, Po H. and
Bartzokis, George and Silverman, Daniel H. S. and
Graff-Radford, Neill R and Parfitt, Francine and Johnson,
Heather and Farlow, Martin R. and Hake, Ann Marie and
Matthews, Brandy R. and Herring, Scott and van Dyck,
Christopher H. and Carson, Richard E. and MacAvoy, Martha G.
and Chertkow, Howard and Bergman, Howard and Hosein, Chris
and Black, Sandra and Stefanovic, Bojana and Caldwell,
Curtis and Hsiung, Ging-Yuek Robin and Feldman, Howard and
Mudge, Benita and Assaly, Michele and Kertesz, Andrew and
Rogers, John and Trost, Dick and Bernick, Charles and Munic,
Donna and Kerwin, Diana and Mesulam, Marek-Marsel and
Lipowski, Kristina and Wu, Chuang-Kuo and Johnson, Nancy and
Sadowsky, Carl and Martinez, Walter and Villena, Teresa and
Scott Turner, Raymond and Johnson, Kathleen and Reynolds,
Brigid and Sperling, Reisa A. and Johnson, Keith A. and
Marshall, Gad and Frey, Meghan and Yesavage, Jerome and
Taylor, Joy L. and Lane, Barton and Rosen, Allyson and
Tinklenberg, Jared and Sabbagh, Marwan and Belden, Christine
and Jacobson, Sandra and Kowall, Neil and Killiany, Ronald
and Budson, Andrew E. and Norbash, Alexander and Johnson,
Patricia Lynn and Obisesan, Thomas O. and Wolday, Saba and
Bwayo, Salome K. and Lerner, Alan and Hudson, Leon and
Ogrocki, Paula and Fletcher, Evan and Carmichael, Owen and
Olichney, John and DeCarli, Charles and Kittur, Smita and
Borrie, Michael and Lee, T-Y and Bartha, Rob and Johnson,
Sterling and Asthana, Sanjay and Carlsson, Cynthia M. and
Potkin, Steven G. and Preda, Adrian and Nguyen, Dana and
Tariot, Pierre and Fleisher, Adam and Reeder, Stephanie and
Bates, Vernice and Capote, Horacio and Rainka, Michelle and
Scharre, Douglas W. and Kataki, Maria and Zimmerman, Earl A.
and Celmins, Dzintra and Brown, Alice D. and Pearlson,
Godfrey D. and Blank, Karen and Anderson, Karen and Saykin,
Andrew J. and Santulli, Robert B. and Schwartz, Eben S. and
Sink, Kaycee M. and Williamson, Jeff D. and Garg, Pradeep
and Watkins, Franklin and Ott, Brian R. and Querfurth, Henry
and Tremont, Geoffrey and Salloway, Stephen and Malloy, Paul
and Correia, Stephen and Rosen, Howard J. and Miller, Bruce
L. and Mintzer, Jacobo and Longmire, Crystal Flynn and
Spicer, Kenneth and Finger, Elizabether and Rachinsky, Irina
and Rogers, John and Kertesz, Andrew and Drost, Dick and
Pomara, Nunzio and Hernando, Raymundo and Sarrael, Antero
and Schultz, Susan K. and Boles Ponto, Laura L. and Shim,
Hyungsub and Smith, Karen Elizabeth and Relkin, Norman and
Chaing, Gloria and Raudin, Lisa and Smith, Amanda and
Fargher, Kristin and Raj, Balebail Ashok},
collaboration = {Initiative, Alzheimer's Disease Neuroimaging},
title = {{N}europathologic features associated with basal forebrain
atrophy in {A}lzheimer disease.},
journal = {Neurology},
volume = {95},
number = {10},
issn = {1526-632X},
address = {[S.l.]},
publisher = {Ovid},
reportid = {DZNE-2021-00222},
pages = {e1301 - e1311},
year = {2020},
note = {ISSN 1526-632X not unique: **3 hits**.},
abstract = {To study the neuropathologic correlates of cholinergic
basal forebrain (BF) atrophy as determined using antemortem
MRI in the Alzheimer disease (AD) spectrum.We determined
associations between BF volume from antemortem MRI brain
scans and postmortem assessment of neuropathologic features,
including neuritic plaques, neurofibrillary tangles (NFTs),
Lewy body (LB) pathology, and TDP-43, in 64 cases of the
Alzheimer's Disease Neuroimaging Initiative cohort. For
comparison, we assessed neuropathologic features associated
with hippocampal and parahippocampal gyrus atrophy. In
addition to region of interest-based analysis, we determined
the association of neuropathologic features with whole brain
gray matter volume using regionally unbiased voxel-based
volumetry.BF atrophy was associated with Thal amyloid phases
$(95\%$ confidence interval [CI] -0.49 to -0.01, p = 0.049)
and presence of LB pathology $(95\%$ CI -0.54 to -0.06, p =
0.015), as well as with the degree of LB pathology within
the nucleus basalis Meynert $(95\%$ CI -0.54 to -0.07, p =
0.025). These effects were no longer significant after false
discovery rate (FDR) correction. Hippocampal atrophy was
significantly associated with the presence of TDP-43
pathology $(95\%$ CI -0.61 to -0.17, p = 0.003; surviving
FDR correction), in addition to dentate gyrus NFT load
$(95\%$ CI -0.49 to -0.01, p = 0.044; uncorrected).
Voxel-based analysis confirmed spatially restricted effects
of Thal phases and presence of LB pathology on BF
volume.These findings indicate that neuropathologic
correlates of regional atrophy differ substantially between
different brain regions that are typically involved in
AD-related neurodegeneration, including different
susceptibilities to common comorbid pathologies.},
keywords = {Aged / Aged, 80 and over / Alzheimer Disease: diagnostic
imaging / Alzheimer Disease: pathology / Atrophy: pathology
/ Basal Forebrain: diagnostic imaging / Basal Forebrain:
pathology / Female / Humans / Magnetic Resonance Imaging /
Male},
cin = {AG Teipel},
ddc = {610},
cid = {I:(DE-2719)1510100},
pnm = {344 - Clinical and Health Care Research (POF3-344)},
pid = {G:(DE-HGF)POF3-344},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:32631924},
pmc = {pmc:PMC7538215},
doi = {10.1212/WNL.0000000000010192},
url = {https://pub.dzne.de/record/154369},
}
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