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@ARTICLE{Kugler:154666,
      author       = {Kugler, Christof and Thielscher, Christian and Tambe,
                      Bertrand A and Schwarz, Martin K and Halle, Annett and
                      Bradke, Frank and Petzold, Gabor C},
      title        = {{E}pothilones {I}mprove {A}xonal {G}rowth and {M}otor
                      {O}utcomes after {S}troke in the {A}dult {M}ammalian {CNS}.},
      journal      = {Cell reports / Medicine},
      volume       = {1},
      number       = {9},
      issn         = {2666-3791},
      address      = {Maryland Heights, MO},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-00295},
      pages        = {100159},
      year         = {2020},
      abstract     = {Stroke leads to the degeneration of short-range and
                      long-range axonal connections emanating from peri-infarct
                      tissue, but it also induces novel axonal projections.
                      However, this regeneration is hampered by growth-inhibitory
                      properties of peri-infarct tissue and fibrotic scarring.
                      Here, we tested the effects of epothilone B and epothilone
                      D, FDA-approved microtubule-stabilizing drugs that are
                      powerful modulators of axonal growth and scar formation, on
                      neuroplasticity and motor outcomes in a photothrombotic
                      mouse model of cortical stroke. We find that both drugs,
                      when administered systemically 1 and 15 days after stroke,
                      augment novel peri-infarct projections connecting the
                      peri-infarct motor cortex with neighboring areas. Both drugs
                      also increase the magnitude of long-range motor projections
                      into the brainstem and reduce peri-infarct fibrotic
                      scarring. Finally, epothilone treatment induces an
                      improvement in skilled forelimb motor function. Thus,
                      pharmacological microtubule stabilization represents a
                      promising target for therapeutic intervention with a wide
                      time window to ameliorate structural and functional sequelae
                      after stroke.},
      keywords     = {Animals / Axons: drug effects / Central Nervous System:
                      drug effects / Central Nervous System: physiopathology /
                      Disease Models, Animal / Epothilones: pharmacology / Mammals
                      / Motor Cortex: drug effects / Neuronal Plasticity: drug
                      effects / Neurons: drug effects / Recovery of Function: drug
                      effects / Recovery of Function: physiology / Stroke: drug
                      therapy / axon regeneration (Other) / fibrotic scar (Other)
                      / ischemia (Other) / neuroplasticity (Other) / stroke
                      (Other)},
      cin          = {AG Petzold ; AG Petzold / AG Halle / AG Bradke},
      ddc          = {610},
      cid          = {I:(DE-2719)1013020 / I:(DE-2719)1013034 /
                      I:(DE-2719)1013002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      experiment   = {EXP:(DE-2719)LMF-20190308 / EXP:(DE-2719)IDAF-20190308},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33377130},
      pmc          = {pmc:PMC7762779},
      doi          = {10.1016/j.xcrm.2020.100159},
      url          = {https://pub.dzne.de/record/154666},
}