000154741 001__ 154741
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000154741 0247_ $$2doi$$a10.1002/alz.12150
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000154741 0247_ $$2ISSN$$a1552-5279
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000154741 037__ $$aDZNE-2021-00331
000154741 041__ $$aEnglish
000154741 082__ $$a610
000154741 1001_ $$aFinsterwalder, Sofia$$b0
000154741 245__ $$aSmall vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients
000154741 260__ $$aHoboken, NJ$$bWiley$$c2020
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000154741 520__ $$aMicrostructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations.We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures.SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel-wise analyses between tau and diffusion measures were not significant.In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD.
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000154741 650_7 $$2Other$$aAlzheimer's disease
000154741 650_7 $$2Other$$abiomarker
000154741 650_7 $$2Other$$acerebral small vessel disease
000154741 650_7 $$2Other$$adiffusion tensor imaging
000154741 650_7 $$2Other$$afree water imaging
000154741 650_7 $$2Other$$awhite matter
000154741 650_2 $$2MeSH$$aAdult
000154741 650_2 $$2MeSH$$aAged
000154741 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000154741 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000154741 650_2 $$2MeSH$$aBrain: diagnostic imaging
000154741 650_2 $$2MeSH$$aBrain: pathology
000154741 650_2 $$2MeSH$$aCerebral Small Vessel Diseases: diagnostic imaging
000154741 650_2 $$2MeSH$$aCerebral Small Vessel Diseases: pathology
000154741 650_2 $$2MeSH$$aDiffusion Magnetic Resonance Imaging
000154741 650_2 $$2MeSH$$aFemale
000154741 650_2 $$2MeSH$$aHumans
000154741 650_2 $$2MeSH$$aMale
000154741 650_2 $$2MeSH$$aMiddle Aged
000154741 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000154741 7001_ $$aVlegels, Naomi$$b1
000154741 7001_ $$0P:(DE-2719)9001112$$aGesierich, Benno$$b2
000154741 7001_ $$0P:(DE-2719)2812570$$aAraque Caballero, Miguel Angel$$b3
000154741 7001_ $$aWeaver, Nick A$$b4
000154741 7001_ $$aFranzmeier, Nicolai$$b5
000154741 7001_ $$aGeorgakis, Marios K$$b6
000154741 7001_ $$aKonieczny, Marek J$$b7
000154741 7001_ $$aKoek, Huiberdina L$$b8
000154741 7001_ $$aNetwork, Dominantly Inherited Alzheimer$$b9$$eCollaboration Author
000154741 7001_ $$aKarch, Celeste M$$b10
000154741 7001_ $$aGraff-Radford, Neill R$$b11
000154741 7001_ $$aSalloway, Stephen$$b12
000154741 7001_ $$aOh, Hwamee$$b13
000154741 7001_ $$aAllegri, Ricardo F$$b14
000154741 7001_ $$aChhatwal, Jasmeer P$$b15
000154741 7001_ $$agroup, DELCODE study$$b16$$eCollaboration Author
000154741 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b17
000154741 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b18
000154741 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b19
000154741 7001_ $$0P:(DE-2719)9000443$$aMetzger, Coraline$$b20
000154741 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b21
000154741 7001_ $$aIncesoy, Enise I$$b22
000154741 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b23
000154741 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b24
000154741 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b25
000154741 7001_ $$0P:(DE-2719)2811326$$aFließbach, Klaus$$b26
000154741 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b27
000154741 7001_ $$0P:(DE-HGF)0$$aJanowitz, Daniel$$b28
000154741 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b29
000154741 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b30
000154741 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b31
000154741 7001_ $$0P:(DE-2719)9000383$$aBuchmann, Martina$$b32
000154741 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b33
000154741 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b34
000154741 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b35
000154741 7001_ $$0P:(DE-2719)2812341$$aRoy, Nina$$b36
000154741 7001_ $$aErtl-Wagner, Birgit$$b37
000154741 7001_ $$aScheffler, Klaus$$b38
000154741 7001_ $$aInitiative, Alzheimer's Disease Neuroimaging$$b39$$eCollaboration Author
000154741 7001_ $$agroup, Utrecht VCI study$$b40$$eCollaboration Author
000154741 7001_ $$aSeo, Sang Won$$b41
000154741 7001_ $$aKim, Yeshin$$b42
000154741 7001_ $$aNa, Duk L$$b43
000154741 7001_ $$aKim, Hee Jin$$b44
000154741 7001_ $$aJang, Hyemin$$b45
000154741 7001_ $$0P:(DE-HGF)0$$aEwers, Michael$$b46
000154741 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b47
000154741 7001_ $$0P:(DE-2719)9000857$$aSchmidt, Reinhold$$b48
000154741 7001_ $$aPasternak, Ofer$$b49
000154741 7001_ $$0P:(DE-HGF)0$$aDichgans, Martin$$b50
000154741 7001_ $$aBiessels, Geert Jan$$b51
000154741 7001_ $$aDuering, Marco$$b52
000154741 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12150$$gVol. 16, no. 11, p. 1504 - 1514$$n11$$p1504 - 1514$$tAlzheimer's and dementia$$v16$$x1552-5279$$y2020
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