TY  - JOUR
AU  - Finsterwalder, Sofia
AU  - Vlegels, Naomi
AU  - Gesierich, Benno
AU  - Araque Caballero, Miguel Angel
AU  - Weaver, Nick A
AU  - Franzmeier, Nicolai
AU  - Georgakis, Marios K
AU  - Konieczny, Marek J
AU  - Koek, Huiberdina L
AU  - Karch, Celeste M
AU  - Graff-Radford, Neill R
AU  - Salloway, Stephen
AU  - Oh, Hwamee
AU  - Allegri, Ricardo F
AU  - Chhatwal, Jasmeer P
AU  - Jessen, Frank
AU  - Düzel, Emrah
AU  - Dobisch, Laura
AU  - Metzger, Coraline
AU  - Peters, Oliver
AU  - Incesoy, Enise I
AU  - Priller, Josef
AU  - Spruth, Eike Jakob
AU  - Schneider, Anja
AU  - Fließbach, Klaus
AU  - Bürger, Katharina
AU  - Janowitz, Daniel
AU  - Teipel, Stefan
AU  - Kilimann, Ingo
AU  - Laske, Christoph
AU  - Buchmann, Martina
AU  - Heneka, Michael
AU  - Brosseron, Frederic
AU  - Spottke, Annika
AU  - Roy, Nina
AU  - Ertl-Wagner, Birgit
AU  - Scheffler, Klaus
AU  - Seo, Sang Won
AU  - Kim, Yeshin
AU  - Na, Duk L
AU  - Kim, Hee Jin
AU  - Jang, Hyemin
AU  - Ewers, Michael
AU  - Levin, Johannes
AU  - Schmidt, Reinhold
AU  - Pasternak, Ofer
AU  - Dichgans, Martin
AU  - Biessels, Geert Jan
AU  - Duering, Marco
TI  - Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients
JO  - Alzheimer's and dementia
VL  - 16
IS  - 11
SN  - 1552-5279
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2021-00331
SP  - 1504 - 1514
PY  - 2020
AB  - Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations.We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures.SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel-wise analyses between tau and diffusion measures were not significant.In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD.
KW  - Adult
KW  - Aged
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: pathology
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Cerebral Small Vessel Diseases: diagnostic imaging
KW  - Cerebral Small Vessel Diseases: pathology
KW  - Diffusion Magnetic Resonance Imaging
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Alzheimer's disease (Other)
KW  - biomarker (Other)
KW  - cerebral small vessel disease (Other)
KW  - diffusion tensor imaging (Other)
KW  - free water imaging (Other)
KW  - white matter (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:32808747
C2  - pmc:PMC8102202
DO  - DOI:10.1002/alz.12150
UR  - https://pub.dzne.de/record/154741
ER  -