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@ARTICLE{Finsterwalder:154741,
      author       = {Finsterwalder, Sofia and Vlegels, Naomi and Gesierich,
                      Benno and Araque Caballero, Miguel Angel and Weaver, Nick A
                      and Franzmeier, Nicolai and Georgakis, Marios K and
                      Konieczny, Marek J and Koek, Huiberdina L and Karch, Celeste
                      M and Graff-Radford, Neill R and Salloway, Stephen and Oh,
                      Hwamee and Allegri, Ricardo F and Chhatwal, Jasmeer P and
                      Jessen, Frank and Düzel, Emrah and Dobisch, Laura and
                      Metzger, Coraline and Peters, Oliver and Incesoy, Enise I
                      and Priller, Josef and Spruth, Eike Jakob and Schneider,
                      Anja and Fließbach, Klaus and Bürger, Katharina and
                      Janowitz, Daniel and Teipel, Stefan and Kilimann, Ingo and
                      Laske, Christoph and Buchmann, Martina and Heneka, Michael
                      and Brosseron, Frederic and Spottke, Annika and Roy, Nina
                      and Ertl-Wagner, Birgit and Scheffler, Klaus and Seo, Sang
                      Won and Kim, Yeshin and Na, Duk L and Kim, Hee Jin and Jang,
                      Hyemin and Ewers, Michael and Levin, Johannes and Schmidt,
                      Reinhold and Pasternak, Ofer and Dichgans, Martin and
                      Biessels, Geert Jan and Duering, Marco},
      collaboration = {Network, Dominantly Inherited Alzheimer and group, DELCODE
                      study and Initiative, Alzheimer's Disease Neuroimaging and
                      group, Utrecht VCI study},
      title        = {{S}mall vessel disease more than {A}lzheimer's disease
                      determines diffusion {MRI} alterations in memory clinic
                      patients},
      journal      = {Alzheimer's and dementia},
      volume       = {16},
      number       = {11},
      issn         = {1552-5279},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-00331},
      pages        = {1504 - 1514},
      year         = {2020},
      abstract     = {Microstructural alterations as assessed by diffusion tensor
                      imaging (DTI) are key findings in both Alzheimer's disease
                      (AD) and small vessel disease (SVD). We determined the
                      contribution of each of these conditions to diffusion
                      alterations.We studied six samples (N = 365 participants)
                      covering the spectrum of AD and SVD, including genetically
                      defined samples. We calculated diffusion measures from DTI
                      and free water imaging. Simple linear, multivariable random
                      forest, and voxel-based regressions were used to evaluate
                      associations between AD biomarkers (amyloid beta, tau), SVD
                      imaging markers, and diffusion measures.SVD markers were
                      strongly associated with diffusion measures and showed a
                      higher contribution than AD biomarkers in multivariable
                      analysis across all memory clinic samples. Voxel-wise
                      analyses between tau and diffusion measures were not
                      significant.In memory clinic patients, the effect of SVD on
                      diffusion alterations largely exceeds the effect of AD,
                      supporting the value of diffusion measures as markers of
                      SVD.},
      keywords     = {Adult / Aged / Alzheimer Disease: diagnostic imaging /
                      Alzheimer Disease: pathology / Brain: diagnostic imaging /
                      Brain: pathology / Cerebral Small Vessel Diseases:
                      diagnostic imaging / Cerebral Small Vessel Diseases:
                      pathology / Diffusion Magnetic Resonance Imaging / Female /
                      Humans / Male / Middle Aged / Alzheimer's disease (Other) /
                      biomarker (Other) / cerebral small vessel disease (Other) /
                      diffusion tensor imaging (Other) / free water imaging
                      (Other) / white matter (Other)},
      cin          = {AG Levin / AG Jessen / AG Speck / AG Düzel / Magdeburg
                      common / AG Endres / AG Priller / AG Schneider / Patient
                      Studies (Bonn) / Clinical Research (Munich) / AG Teipel /
                      ICRU / Tübingen common / Biomarker / Clinical Research
                      (Bonn) / Clinical Research Platform (CRP) / Rostock /
                      Greifswald common},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016 / I:(DE-2719)1011102 /
                      I:(DE-2719)1340009 / I:(DE-2719)5000006 / I:(DE-2719)6000015
                      / I:(DE-2719)1811005 / I:(DE-2719)5000007 /
                      I:(DE-2719)1011305 / I:(DE-2719)1011101 / I:(DE-2719)1111015
                      / I:(DE-2719)1510100 / I:(DE-2719)1240005 /
                      I:(DE-2719)6000018 / I:(DE-2719)1011301 / I:(DE-2719)1011001
                      / I:(DE-2719)1011401 / I:(DE-2719)6000017},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32808747},
      pmc          = {pmc:PMC8102202},
      doi          = {10.1002/alz.12150},
      url          = {https://pub.dzne.de/record/154741},
}