Home > Publications Database > Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients > print

001     154741
005     20250414155012.0
024 7 _ |a 10.1002/alz.12150
|2 doi
024 7 _ |a pmid:32808747
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024 7 _ |a pmc:PMC8102202
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024 7 _ |a 1552-5260
|2 ISSN
024 7 _ |a 1552-5279
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024 7 _ |a altmetric:88503015
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037 _ _ |a DZNE-2021-00331
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Finsterwalder, Sofia
|b 0
245 _ _ |a Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients
260 _ _ |a Hoboken, NJ
|c 2020
|b Wiley
336 7 _ |a article
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336 7 _ |a Journal Article
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|s 1744638573_21650
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations.We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures.SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel-wise analyses between tau and diffusion measures were not significant.In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a biomarker
|2 Other
650 _ 7 |a cerebral small vessel disease
|2 Other
650 _ 7 |a diffusion tensor imaging
|2 Other
650 _ 7 |a free water imaging
|2 Other
650 _ 7 |a white matter
|2 Other
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Alzheimer Disease: diagnostic imaging
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
650 _ 2 |a Cerebral Small Vessel Diseases: diagnostic imaging
|2 MeSH
650 _ 2 |a Cerebral Small Vessel Diseases: pathology
|2 MeSH
650 _ 2 |a Diffusion Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
693 _ _ |0 EXP:(DE-2719)DELCODE-20140101
|5 EXP:(DE-2719)DELCODE-20140101
|e Longitudinal Cognitive Impairment and Dementia Study
|x 0
700 1 _ |a Vlegels, Naomi
|b 1
700 1 _ |a Gesierich, Benno
|0 P:(DE-2719)9001112
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700 1 _ |a Araque Caballero, Miguel Angel
|0 P:(DE-2719)2812570
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700 1 _ |a Weaver, Nick A
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700 1 _ |a Franzmeier, Nicolai
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700 1 _ |a Georgakis, Marios K
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700 1 _ |a Konieczny, Marek J
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700 1 _ |a Koek, Huiberdina L
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700 1 _ |a Network, Dominantly Inherited Alzheimer
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700 1 _ |a Karch, Celeste M
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700 1 _ |a Graff-Radford, Neill R
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700 1 _ |a Salloway, Stephen
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700 1 _ |a Oh, Hwamee
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700 1 _ |a Allegri, Ricardo F
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700 1 _ |a Chhatwal, Jasmeer P
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700 1 _ |a group, DELCODE study
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700 1 _ |a Jessen, Frank
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700 1 _ |a Düzel, Emrah
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700 1 _ |a Dobisch, Laura
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700 1 _ |a Metzger, Coraline
|0 P:(DE-2719)9000443
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700 1 _ |a Peters, Oliver
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700 1 _ |a Incesoy, Enise I
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700 1 _ |a Priller, Josef
|0 P:(DE-2719)2811122
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700 1 _ |a Spruth, Eike Jakob
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700 1 _ |a Schneider, Anja
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700 1 _ |a Fließbach, Klaus
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700 1 _ |a Bürger, Katharina
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700 1 _ |a Janowitz, Daniel
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700 1 _ |a Teipel, Stefan
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700 1 _ |a Kilimann, Ingo
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700 1 _ |a Laske, Christoph
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700 1 _ |a Buchmann, Martina
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700 1 _ |a Heneka, Michael
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700 1 _ |a Brosseron, Frederic
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700 1 _ |a Spottke, Annika
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700 1 _ |a Roy, Nina
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700 1 _ |a Ertl-Wagner, Birgit
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700 1 _ |a Scheffler, Klaus
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700 1 _ |a Initiative, Alzheimer's Disease Neuroimaging
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700 1 _ |a group, Utrecht VCI study
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700 1 _ |a Seo, Sang Won
|b 41
700 1 _ |a Kim, Yeshin
|b 42
700 1 _ |a Na, Duk L
|b 43
700 1 _ |a Kim, Hee Jin
|b 44
700 1 _ |a Jang, Hyemin
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700 1 _ |a Ewers, Michael
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700 1 _ |a Levin, Johannes
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700 1 _ |a Schmidt, Reinhold
|0 P:(DE-2719)9000857
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700 1 _ |a Pasternak, Ofer
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700 1 _ |a Dichgans, Martin
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700 1 _ |a Biessels, Geert Jan
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700 1 _ |a Duering, Marco
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773 _ _ |a 10.1002/alz.12150
|g Vol. 16, no. 11, p. 1504 - 1514
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