% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Taylor:155166,
      author       = {Taylor, James and Hasegawa, Masashi and Benoit, Chloé
                      Maëlle and Freire, Joana Amorim and Theodore, Marine and
                      Ganea, Dan Alin and Innocenti, Sabrina Milena and Lu,
                      Tingjia and Gründemann, Jan},
      title        = {{S}ingle cell plasticity and population coding stability in
                      auditory thalamus upon associative learning},
      journal      = {Nature Communications},
      volume       = {12},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2021-00487},
      pages        = {2438},
      year         = {2021},
      abstract     = {Cortical and limbic brain areas are regarded as centres for
                      learning. However, how thalamic sensory relays participate
                      in plasticity upon associative learning, yet support stable
                      long-term sensory coding remains unknown. Using a miniature
                      microscope imaging approach, we monitor the activity of
                      populations of auditory thalamus (medial geniculate body)
                      neurons in freely moving mice upon fear conditioning. We
                      find that single cells exhibit mixed selectivity and
                      heterogeneous plasticity patterns to auditory and aversive
                      stimuli upon learning, which is conserved in
                      amygdala-projecting medial geniculate body neurons. Activity
                      in auditory thalamus to amygdala-projecting neurons
                      stabilizes single cell plasticity in the total medial
                      geniculate body population and is necessary for fear memory
                      consolidation. In contrast to individual cells, population
                      level encoding of auditory stimuli remained stable across
                      days. Our data identifies auditory thalamus as a site for
                      complex neuronal plasticity in fear learning upstream of the
                      amygdala that is in an ideal position to drive plasticity in
                      cortical and limbic brain areas. These findings suggest that
                      medial geniculate body’s role goes beyond a sole relay
                      function by balancing experience-dependent, diverse single
                      cell plasticity with consistent ensemble level
                      representations of the sensory environment to support stable
                      auditory perception with minimal affective bias.},
      keywords     = {Acoustic Stimulation / Amygdala: cytology / Amygdala:
                      physiology / Animals / Auditory Pathways: physiology /
                      Auditory Perception: physiology / Cell Plasticity:
                      physiology / Conditioning, Classical: physiology / Fear:
                      physiology / Geniculate Bodies: cytology / Geniculate
                      Bodies: physiology / Learning: physiology / Mice, Inbred
                      C57BL / Neuronal Plasticity: physiology / Neurons:
                      physiology / Thalamus: cytology / Thalamus: physiology},
      cin          = {AG Gründemann},
      ddc          = {500},
      cid          = {I:(DE-2719)5000069},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33903596},
      pubmed       = {33903596},
      pmc          = {pmc:PMC8076296},
      doi          = {10.1038/s41467-021-22421-8},
      url          = {https://pub.dzne.de/record/155166},
}