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000155271 0247_ $$2ISSN$$a1460-2075
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000155271 041__ $$aEnglish
000155271 082__ $$a570
000155271 1001_ $$aBedrosian, Tracy A$$b0
000155271 245__ $$aLamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis
000155271 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2021
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000155271 520__ $$aNeurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age-dependent downregulation of lamin B1, one of the nuclear lamins in adult neural stem/progenitor cells (ANSPCs), underlies age-related alterations in adult hippocampal neurogenesis. Our results indicate that higher levels of lamin B1 in ANSPCs safeguard against premature differentiation and regulate the maintenance of ANSPCs. However, the level of lamin B1 in ANSPCs declines during aging. Precocious loss of lamin B1 in ANSPCs transiently promotes neurogenesis but eventually depletes it. Furthermore, the reduction of lamin B1 in ANSPCs recapitulates age-related anxiety-like behavior in mice. Our results indicate that the decline in lamin B1 underlies stem cell aging and impacts the homeostasis of adult neurogenesis and mood regulation.
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000155271 650_2 $$2MeSH$$aAging: genetics
000155271 650_2 $$2MeSH$$aAging: metabolism
000155271 650_2 $$2MeSH$$aAnimals
000155271 650_2 $$2MeSH$$aAnxiety: genetics
000155271 650_2 $$2MeSH$$aCell Differentiation
000155271 650_2 $$2MeSH$$aCell Line
000155271 650_2 $$2MeSH$$aDisease Models, Animal
000155271 650_2 $$2MeSH$$aDown-Regulation
000155271 650_2 $$2MeSH$$aFemale
000155271 650_2 $$2MeSH$$aHippocampus: cytology
000155271 650_2 $$2MeSH$$aHippocampus: metabolism
000155271 650_2 $$2MeSH$$aLamin Type B: genetics
000155271 650_2 $$2MeSH$$aLamin Type B: metabolism
000155271 650_2 $$2MeSH$$aMale
000155271 650_2 $$2MeSH$$aMice
000155271 650_2 $$2MeSH$$aNeural Stem Cells: cytology
000155271 650_2 $$2MeSH$$aNeural Stem Cells: metabolism
000155271 650_2 $$2MeSH$$aNeurogenesis
000155271 650_2 $$2MeSH$$aRats
000155271 7001_ $$0P:(DE-2719)9000586$$aHoutman, Judith$$b1
000155271 7001_ $$0P:(DE-2719)9001509$$aEguiguren, Juan Sebastian$$b2$$udzne
000155271 7001_ $$00000-0003-3782-1796$$aGhassemzadeh, Saeed$$b3
000155271 7001_ $$0P:(DE-2719)2811674$$aRund, Nicole$$b4
000155271 7001_ $$00000-0001-7890-4382$$aNovaresi, Nicole M$$b5
000155271 7001_ $$aHu, Lauren$$b6
000155271 7001_ $$00000-0003-1756-0736$$aParylak, Sarah L.$$b7
000155271 7001_ $$aDenli, Ahmet M$$b8
000155271 7001_ $$aRandolph-Moore, Lynne$$b9
000155271 7001_ $$aNamba, Takashi$$b10
000155271 7001_ $$00000-0002-0938-4106$$aGage, Fred H$$b11
000155271 7001_ $$0P:(DE-2719)2814117$$aToda, Tomohisa$$b12$$eLast author
000155271 773__ $$0PERI:(DE-600)1467419-1$$a10.15252/embj.2020105819$$gVol. 40, no. 3$$n3$$pe105819$$tThe EMBO journal$$v40$$x1460-2075$$y2021
000155271 8564_ $$uhttps://www.embopress.org/doi/full/10.15252/embj.2020105819
000155271 8564_ $$uhttps://pub.dzne.de/record/155271/files/7833.pdf$$yOpenAccess
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