Home > Publications Database > Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis > print

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005     20240320115508.0
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024 7 _ |a 1460-2075
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100 1 _ |a Bedrosian, Tracy A
|b 0
245 _ _ |a Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis
260 _ _ |a Hoboken, NJ [u.a.]
|c 2021
|b Wiley
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520 _ _ |a Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age-dependent downregulation of lamin B1, one of the nuclear lamins in adult neural stem/progenitor cells (ANSPCs), underlies age-related alterations in adult hippocampal neurogenesis. Our results indicate that higher levels of lamin B1 in ANSPCs safeguard against premature differentiation and regulate the maintenance of ANSPCs. However, the level of lamin B1 in ANSPCs declines during aging. Precocious loss of lamin B1 in ANSPCs transiently promotes neurogenesis but eventually depletes it. Furthermore, the reduction of lamin B1 in ANSPCs recapitulates age-related anxiety-like behavior in mice. Our results indicate that the decline in lamin B1 underlies stem cell aging and impacts the homeostasis of adult neurogenesis and mood regulation.
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650 _ 2 |a Aging: genetics
|2 MeSH
650 _ 2 |a Aging: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Anxiety: genetics
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
650 _ 2 |a Cell Line
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Down-Regulation
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Hippocampus: cytology
|2 MeSH
650 _ 2 |a Hippocampus: metabolism
|2 MeSH
650 _ 2 |a Lamin Type B: genetics
|2 MeSH
650 _ 2 |a Lamin Type B: metabolism
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Neural Stem Cells: cytology
|2 MeSH
650 _ 2 |a Neural Stem Cells: metabolism
|2 MeSH
650 _ 2 |a Neurogenesis
|2 MeSH
650 _ 2 |a Rats
|2 MeSH
700 1 _ |a Houtman, Judith
|0 P:(DE-2719)9000586
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700 1 _ |a Eguiguren, Juan Sebastian
|0 P:(DE-2719)9001509
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700 1 _ |a Ghassemzadeh, Saeed
|0 0000-0003-3782-1796
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700 1 _ |a Rund, Nicole
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700 1 _ |a Novaresi, Nicole M
|0 0000-0001-7890-4382
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700 1 _ |a Hu, Lauren
|b 6
700 1 _ |a Parylak, Sarah L.
|0 0000-0003-1756-0736
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700 1 _ |a Denli, Ahmet M
|b 8
700 1 _ |a Randolph-Moore, Lynne
|b 9
700 1 _ |a Namba, Takashi
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700 1 _ |a Gage, Fred H
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700 1 _ |a Toda, Tomohisa
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773 _ _ |a 10.15252/embj.2020105819
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856 4 _ |u https://www.embopress.org/doi/full/10.15252/embj.2020105819
856 4 _ |u https://pub.dzne.de/record/155271/files/7833.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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