%0 Journal Article
%A de Rojas, Itziar
%A Moreno-Grau, Sonia
%A Tesi, Niccolo
%A Grenier-Boley, Benjamin
%A Andrade, Victor
%A Jansen, Iris
%A Pedersen, Nancy L
%A Stringa, Najada
%A Zettergren, Anna
%A Hernández, Isabel
%A Montrreal, Laura
%A Antúnez, Carmen
%A Antonell, Anna
%A Tankard, Rick M
%A Bis, Joshua C
%A Sims, Rebecca
%A Bellenguez, Céline
%A Quintela, Inés
%A González-Perez, Antonio
%A Calero, Miguel
%A Franco-Macías, Emilio
%A Macías, Juan
%A Blesa, Rafael
%A Cervera-Carles, Laura
%A Menéndez-González, Manuel
%A Frank-García, Ana
%A Royo, Jose Luís
%A Moreno, Fermin
%A Huerto Vilas, Raquel
%A Baquero, Miquel
%A Diez-Fairen, Mónica
%A Lage, Carmen
%A García-Madrona, Sebastián
%A García-González, Pablo
%A Alarcón-Martín, Emilio
%A Valero, Sergi
%A Sotolongo-Grau, Oscar
%A Ullgren, Abbe
%A Naj, Adam C
%A Lemstra, Afina W
%A Benaque, Alba
%A Pérez-Cordón, Alba
%A Benussi, Alberto
%A Rábano, Alberto
%A Padovani, Alessandro
%A Squassina, Alessio
%A de Mendonça, Alexandre
%A Arias Pastor, Alfonso
%A Kok, Almar A L
%A Meggy, Alun
%A Pastor, Ana Belén
%A Espinosa, Ana
%A Corma-Gómez, Anaïs
%A Martín Montes, Angel
%A Sanabria, Ángela
%A DeStefano, Anita L
%A Schneider, Anja
%A Haapasalo, Annakaisa
%A Kinhult Ståhlbom, Anne
%A Tybjærg-Hansen, Anne
%A Hartmann, Annette M
%A Spottke, Annika
%A Corbatón-Anchuelo, Arturo
%A Rongve, Arvid
%A Borroni, Barbara
%A Arosio, Beatrice
%A Nacmias, Benedetta
%A Nordestgaard, Børge G
%A Kunkle, Brian W
%A Charbonnier, Camille
%A Abdelnour, Carla
%A Masullo, Carlo
%A Martínez Rodríguez, Carmen
%A Muñoz-Fernandez, Carmen
%A Dufouil, Carole
%A Graff, Caroline
%A Ferreira, Catarina B
%A Chillotti, Caterina
%A Reynolds, Chandra A
%A Fenoglio, Chiara
%A Van Broeckhoven, Christine
%A Clark, Christopher
%A Pisanu, Claudia
%A Satizabal, Claudia L
%A Holmes, Clive
%A Buiza-Rueda, Dolores
%A Aarsland, Dag
%A Rujescu, Dan
%A Alcolea, Daniel
%A Galimberti, Daniela
%A Wallon, David
%A Seripa, Davide
%A Grünblatt, Edna
%A Dardiotis, Efthimios
%A Düzel, Emrah
%A Scarpini, Elio
%A Conti, Elisa
%A Rubino, Elisa
%A Gelpi, Ellen
%A Rodriguez-Rodriguez, Eloy
%A Duron, Emmanuelle
%A Boerwinkle, Eric
%A Ferri, Evelyn
%A Tagliavini, Fabrizio
%A Küçükali, Fahri
%A Pasquier, Florence
%A Sanchez-Garcia, Florentino
%A Mangialasche, Francesca
%A Jessen, Frank
%A Nicolas, Gaël
%A Selbæk, Geir
%A Ortega, Gemma
%A Chêne, Geneviève
%A Hadjigeorgiou, Georgios
%A Rossi, Giacomina
%A Spalletta, Gianfranco
%A Giaccone, Giorgio
%A Grande, Giulia
%A Binetti, Giuliano
%A Papenberg, Goran
%A Hampel, Harald
%A Bailly, Henri
%A Zetterberg, Henrik
%A Soininen, Hilkka
%A Karlsson, Ida K
%A Alvarez, Ignacio
%A Appollonio, Ildebrando
%A Giegling, Ina
%A Skoog, Ingmar
%A Saltvedt, Ingvild
%A Rainero, Innocenzo
%A Rosas Allende, Irene
%A Hort, Jakub
%A Diehl-Schmid, Janine
%A Van Dongen, Jasper
%A Vidal, Jean-Sebastien
%A Lehtisalo, Jenni
%A Wiltfang, Jens
%A Thomassen, Jesper Qvist
%A Kornhuber, Johannes
%A Haines, Jonathan L
%A Vogelgsang, Jonathan
%A Pineda, Juan A
%A Fortea, Juan
%A Popp, Julius
%A Deckert, Jürgen
%A Bürger, Katharina
%A Morgan, Kevin
%A Fließbach, Klaus
%A Sleegers, Kristel
%A Molina-Porcel, Laura
%A Kilander, Lena
%A Weinhold, Leonie
%A Farrer, Lindsay A
%A Wang, Li-San
%A Kleineidam, Luca
%A Farotti, Lucia
%A Parnetti, Lucilla
%A Tremolizzo, Lucio
%A Hausner, Lucrezia
%A Benussi, Luisa
%A Froelich, Lutz
%A Ikram, M Arfan
%A Deniz-Naranjo, M Candida
%A Tsolaki, Magda
%A Rosende-Roca, Maitée
%A Löwenmark, Malin
%A Hulsman, Marc
%A Spallazzi, Marco
%A Pericak-Vance, Margaret A
%A Esiri, Margaret
%A Bernal Sánchez-Arjona, María
%A Dalmasso, Maria Carolina
%A Martínez-Larrad, María Teresa
%A Arcaro, Marina
%A Nöthen, Markus M
%A Fernández-Fuertes, Marta
%A Dichgans, Martin
%A Ingelsson, Martin
%A Herrmann, Martin J
%A Scherer, Martin
%A Vyhnalek, Martin
%A Kosmidis, Mary H
%A Yannakoulia, Mary
%A Schmid, Matthias
%A Ewers, Michael
%A Heneka, Michael T
%A Wagner, Michael
%A Scamosci, Michela
%A Kivipelto, Miia
%A Hiltunen, Mikko
%A Zulaica, Miren
%A Alegret, Montserrat
%A Fornage, Myriam
%A Roberto, Natalia
%A van Schoor, Natasja M
%A Seidu, Nazib M
%A Banaj, Nerisa
%A Armstrong, Nicola J
%A Scarmeas, Nikolaos
%A Scherbaum, Norbert
%A Goldhardt, Oliver
%A Hanon, Oliver
%A Peters, Oliver
%A Skrobot, Olivia Anna
%A Quenez, Olivier
%A Lerch, Ondrej
%A Bossù, Paola
%A Caffarra, Paolo
%A Dionigi Rossi, Paolo
%A Sakka, Paraskevi
%A Hoffmann, Per
%A Holmans, Peter A
%A Fischer, Peter
%A Riederer, Peter
%A Yang, Qiong
%A Marshall, Rachel
%A Kalaria, Rajesh N
%A Mayeux, Richard
%A Vandenberghe, Rik
%A Cecchetti, Roberta
%A Ghidoni, Roberta
%A Frikke-Schmidt, Ruth
%A Sorbi, Sandro
%A Hägg, Sara
%A Engelborghs, Sebastiaan
%A Helisalmi, Seppo
%A Botne Sando, Sigrid
%A Kern, Silke
%A Archetti, Silvana
%A Boschi, Silvia
%A Fostinelli, Silvia
%A Gil, Silvia
%A Mendoza, Silvia
%A Mead, Simon
%A Ciccone, Simona
%A Djurovic, Srdjan
%A Heilmann-Heimbach, Stefanie
%A Riedel-Heller, Steffi
%A Kuulasmaa, Teemu
%A Del Ser, Teodoro
%A Lebouvier, Thibaud
%A Polak, Thomas
%A Ngandu, Tiia
%A Grimmer, Timo
%A Bessi, Valentina
%A Escott-Price, Valentina
%A Giedraitis, Vilmantas
%A Deramecourt, Vincent
%A Maier, Wolfgang
%A Jian, Xueqiu
%A Pijnenburg, Yolande A L
%A Kehoe, Patrick Gavin
%A Garcia-Ribas, Guillermo
%A Sánchez-Juan, Pascual
%A Pastor, Pau
%A Pérez-Tur, Jordi
%A Piñol-Ripoll, Gerard
%A Lopez de Munain, Adolfo
%A García-Alberca, Jose María
%A Bullido, María J
%A Álvarez, Victoria
%A Lleó, Alberto
%A Real, Luis M
%A Mir, Pablo
%A Medina, Miguel
%A Scheltens, Philip
%A Holstege, Henne
%A Marquié, Marta
%A Sáez, María Eugenia
%A Carracedo, Ángel
%A Amouyel, Philippe
%A Schellenberg, Gerard D
%A Williams, Julie
%A Seshadri, Sudha
%A van Duijn, Cornelia M
%A Mather, Karen A
%A Sánchez-Valle, Raquel
%A Serrano-Ríos, Manuel
%A Orellana, Adelina
%A Tárraga, Lluís
%A Blennow, Kaj
%A Huisman, Martijn
%A Andreassen, Ole A
%A Posthuma, Danielle
%A Clarimón, Jordi
%A Boada, Mercè
%A van der Flier, Wiesje M
%A Ramirez, Alfredo
%A Lambert, Jean-Charles
%A van der Lee, Sven J
%A Ruiz, Agustín
%A Smith, A David
%A Saenz, Aldo
%A Bizzarro, Alessandra
%A Lauria, Alessandra
%A Vacca, Alessandro
%A Solomon, Alina
%A Anastasiou, Anna
%A Richardson, Anna
%A Boland, Anne
%A Koivisto, Anne
%A Daniele, Antonio
%A Greco, Antonio
%A Marianthi, Arnaoutoglou
%A McGuinness, Bernadette
%A Fin, Bertrand
%A Ferrari, Camilla
%A Custodero, Carlo
%A Ferrarese, Carlo
%A Ingino, Carlos
%A Mangone, Carlos
%A Reyes Toso, Carlos
%A Martínez, Carmen
%A Cuesta, Carolina
%A Muchnik, Carolina
%A Joachim, Catharine
%A Ortiz, Cecilia
%A Besse, Céline
%A Johansson, Charlotte
%A Zoia, Chiara Paola
%A Laske, Christoph
%A Anastasiou, Costas
%A Palacio, Dana Lis
%A Politis, Daniel G
%A Janowitz, Daniel
%A Craig, David
%A Mann, David M
%A Neary, David
%A Jürgen, Deckert
%A Daian, Delphine
%A Belezhanska, Diyana
%A Kohler, Eduardo
%A Castaño, Eduardo M
%A Koutsouraki, Effrosyni
%A Chipi, Elena
%A De Roeck, Ellen
%A Costantini, Emanuele
%A Vardy, Emma R L C
%A Piras, Fabrizio
%A Roveta, Fausto
%A Piras, Federica
%A Prestia, Federico Ariel
%A Assogna, Francesca
%A Salani, Francesca
%A Sala, Gessica
%A Lacidogna, Giordano
%A Novack, Gisela
%A Wilcock, Gordon
%A Thonberg, Håkan
%A Kölsch, Heike
%A Weber, Heike
%A Boecker, Henning
%A Etchepareborda, Ignacio
%A Piaceri, Irene
%A Tuomilehto, Jaakko
%A Lindström, Jaana
%A Laczo, Jan
%A Johnston, Janet
%A Deleuze, Jean-François
%A Harris, Jenny
%A Schott, Jonathan M
%A Priller, Josef
%A Bacha, Juan Ignacio
%A Snowden, Julie
%A Lisso, Julieta
%A Mihova, Kalina Yonkova
%A Traykov, Latchezar
%A Morelli, Laura
%A Brusco, Luis Ignacio
%A Rainer, Malik
%A Takalo, Mari
%A Bjerke, Maria
%A Del Zompo, Maria
%A Serpente, Maria
%A Sanchez Abalos, Mariana
%A Rios, Mario
%A Peltonen, Markku
%A Herrman, Martin J
%A Kosmidis, Mary H
%A Kohler, Matias
%A Rojo, Matias
%A Jones, Matthew
%A Orsini, Michela
%A Medel, Nancy
%A Olivar, Natividad
%A Fox, Nick C
%A Salvadori, Nicola
%A Hooper, Nigel M
%A Galeano, Pablo
%A Solis, Patricia
%A Bastiani, Patrizia
%A Mecocci, Patrizia
%A Passmore, Peter
%A Heun, Reinhard
%A Antikainen, Riitta
%A Olaso, Robert
%A Perneczky, Robert
%A Germani, Sandra
%A López-García, Sara
%A Love, Seth
%A Mehrabian, Shima
%A Bagnoli, Silvia
%A Kochen, Silvia
%A Andreoni, Simona
%A Teipel, Stefan
%A Todd, Stephen
%A Pickering-Brown, Stuart
%A Natunen, Teemu
%A Tegos, Thomas
%A Laatikainen, Tiina
%A Strandberg, Timo
%A Polvikoski, Tuomo M
%A Matoska, Vaclav
%A Ciullo, Valentina
%A Cores, Valeria
%A Solfrizzi, Vincenzo
%A Lisetti, Viviana
%A Sevillano, Zulma
%A Abdelnour, C.
%A Aguilera, N.
%A Alarcon, E.
%A Alegret, M.
%A Benaque, A.
%A Boada, M.
%A Buendia, M.
%A Cañabate, P.
%A Carracedo, A.
%A Corbatón-Anchuelo, A.
%A de Rojas, I.
%A Diego, S.
%A Espinosa, A.
%A Gailhajenet, A.
%A García-González, P.
%A Gil, S.
%A Guitart, M.
%A González-Pérez, A.
%A Hernández, I.
%A Ibarria, M.
%A Lafuente, A.
%A Macias, J.
%A Maroñas, O.
%A Martín, E.
%A Martínez, M. T.
%A Marquié, M.
%A Mauleón, A.
%A Montrreal, L.
%A Moreno-Grau, S.
%A Moreno, M.
%A Orellana, A.
%A Ortega, G.
%A Pancho, A.
%A Pelejá, E.
%A Pérez-Cordon, A.
%A Pineda, J. A.
%A Preckler, S.
%A Quintela, I.
%A Real, L. M.
%A Rosende-Roca, M.
%A Ruiz, A.
%A Sáez, M. E.
%A Sanabria, A.
%A Serrano-Rios, M.
%A Sotolongo-Grau, O.
%A Tárraga, L.
%A Valero, S.
%A Vargas, L.
%A Adarmes-Gómez, A. D.
%A Alarcón-Martín, E.
%A Alonso, M. D.
%A Álvarez, I.
%A Álvarez, V.
%A Amer-Ferrer, G.
%A Antequera, M.
%A Antúnez, C.
%A Baquero, M.
%A Bernal, M.
%A Blesa, R.
%A Boada, M.
%A Buiza-Rueda, D.
%A Bullido, M. J.
%A Burguera, J. A.
%A Calero, M.
%A Carrillo, F.
%A Carrión-Claro, M.
%A Casajeros, M. J.
%A Clarimón, J.
%A Cruz-Gamero, J. M.
%A de Pancorbo, M. M.
%A de Rojas, I.
%A Del Ser, T.
%A Diez-Fairen, M.
%A Escuela, R.
%A Garrote-Espina, L.
%A Fortea, J.
%A Franco-Macías, E.
%A Frank-García, A.
%A García-Alberca, J. M.
%A Garcia Madrona, S.
%A Garcia-Ribas, G.
%A Gómez-Garre, P.
%A Hernández, I.
%A Hevilla, S.
%A Jesús, S.
%A Labrador Espinosa, M. A.
%A Lage, C.
%A Legaz, A.
%A Lleó, A.
%A Lopez de Munain, A.
%A López-García, S.
%A Macias-García, D.
%A Manzanares, S.
%A Marín, M.
%A Marín-Muñoz, J.
%A Marín, T.
%A Marquié, M.
%A Martín Montes, A.
%A Martínez, B.
%A Martínez, C.
%A Martínez, V.
%A Martínez-Lage Álvarez, P.
%A Medina, M.
%A Mendioroz Iriarte, M.
%A Menéndez-González, M.
%A Mir, P.
%A Molinuevo, J. L.
%A Pastor, P.
%A Pérez Tur, J.
%A Periñán-Tocino, T.
%A Pineda-Sanchez, R.
%A Piñol-Ripoll, G.
%A Rábano, A.
%A Real de Asúa, D.
%A Rodrigo, S.
%A Rodríguez-Rodríguez, E.
%A Royo, J. L.
%A Ruiz, A.
%A Sanchez Del Valle Díaz, R.
%A Sánchez-Juan, P.
%A Sastre, I.
%A Valero, S.
%A Vicente, M. P.
%A Vigo-Ortega, R.
%A Vivancos, L.
%A Macleod, C.
%A McCracken, C.
%A Brayne, Carol
%A Bresner, Catherine
%A Grozeva, Detelina
%A Bellou, Eftychia
%A Sommerville, Ewen W
%A Matthews, F.
%A Leonenko, Ganna
%A Menzies, Georgina
%A Windle, Gill
%A Harwood, Janet
%A Phillips, Judith
%A Bennett, K.
%A Luckuck, Lauren
%A Clare, Linda
%A Woods, Robert
%A Saad, Salha
%A Burholt, Vanessa
%A Jansen, Iris E
%A Rongve, Arvid
%T Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
%J Nature Communications
%V 12
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DZNE-2021-00552
%P 3417
%D 2021
%X Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.
%K Age of Onset
%K Aged
%K Aged, 80 and over
%K Alzheimer Disease: epidemiology
%K Alzheimer Disease: genetics
%K Alzheimer Disease: pathology
%K Amyloid beta-Protein Precursor: genetics
%K Amyloid beta-Protein Precursor: metabolism
%K Apolipoproteins E: genetics
%K Case-Control Studies
%K Cohort Studies
%K Datasets as Topic
%K Female
%K Follow-Up Studies
%K Genetic Predisposition to Disease
%K Genome-Wide Association Study
%K Heterozygote
%K Humans
%K Male
%K Middle Aged
%K Multifactorial Inheritance
%K Polymorphism, Single Nucleotide
%K Risk Assessment: methods
%K Risk Factors
%K APP protein, human (NLM Chemicals)
%K Amyloid beta-Protein Precursor (NLM Chemicals)
%K Apolipoproteins E (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34099642
%2 pmc:PMC8184987
%R 10.1038/s41467-021-22491-8
%U https://pub.dzne.de/record/155272