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@ARTICLE{deRojas:155272,
author = {de Rojas, Itziar and Moreno-Grau, Sonia and Tesi, Niccolo
and Grenier-Boley, Benjamin and Andrade, Victor and Jansen,
Iris and Pedersen, Nancy L and Stringa, Najada and
Zettergren, Anna and Hernández, Isabel and Montrreal, Laura
and Antúnez, Carmen and Antonell, Anna and Tankard, Rick M
and Bis, Joshua C and Sims, Rebecca and Bellenguez, Céline
and Quintela, Inés and González-Perez, Antonio and Calero,
Miguel and Franco-Macías, Emilio and Macías, Juan and
Blesa, Rafael and Cervera-Carles, Laura and
Menéndez-González, Manuel and Frank-García, Ana and Royo,
Jose Luís and Moreno, Fermin and Huerto Vilas, Raquel and
Baquero, Miquel and Diez-Fairen, Mónica and Lage, Carmen
and García-Madrona, Sebastián and García-González, Pablo
and Alarcón-Martín, Emilio and Valero, Sergi and
Sotolongo-Grau, Oscar and Ullgren, Abbe and Naj, Adam C and
Lemstra, Afina W and Benaque, Alba and Pérez-Cordón, Alba
and Benussi, Alberto and Rábano, Alberto and Padovani,
Alessandro and Squassina, Alessio and de Mendonça,
Alexandre and Arias Pastor, Alfonso and Kok, Almar A L and
Meggy, Alun and Pastor, Ana Belén and Espinosa, Ana and
Corma-Gómez, Anaïs and Martín Montes, Angel and Sanabria,
Ángela and DeStefano, Anita L and Schneider, Anja and
Haapasalo, Annakaisa and Kinhult Ståhlbom, Anne and
Tybjærg-Hansen, Anne and Hartmann, Annette M and Spottke,
Annika and Corbatón-Anchuelo, Arturo and Rongve, Arvid and
Borroni, Barbara and Arosio, Beatrice and Nacmias, Benedetta
and Nordestgaard, Børge G and Kunkle, Brian W and
Charbonnier, Camille and Abdelnour, Carla and Masullo, Carlo
and Martínez Rodríguez, Carmen and Muñoz-Fernandez,
Carmen and Dufouil, Carole and Graff, Caroline and Ferreira,
Catarina B and Chillotti, Caterina and Reynolds, Chandra A
and Fenoglio, Chiara and Van Broeckhoven, Christine and
Clark, Christopher and Pisanu, Claudia and Satizabal,
Claudia L and Holmes, Clive and Buiza-Rueda, Dolores and
Aarsland, Dag and Rujescu, Dan and Alcolea, Daniel and
Galimberti, Daniela and Wallon, David and Seripa, Davide and
Grünblatt, Edna and Dardiotis, Efthimios and Düzel, Emrah
and Scarpini, Elio and Conti, Elisa and Rubino, Elisa and
Gelpi, Ellen and Rodriguez-Rodriguez, Eloy and Duron,
Emmanuelle and Boerwinkle, Eric and Ferri, Evelyn and
Tagliavini, Fabrizio and Küçükali, Fahri and Pasquier,
Florence and Sanchez-Garcia, Florentino and Mangialasche,
Francesca and Jessen, Frank and Nicolas, Gaël and Selbæk,
Geir and Ortega, Gemma and Chêne, Geneviève and
Hadjigeorgiou, Georgios and Rossi, Giacomina and Spalletta,
Gianfranco and Giaccone, Giorgio and Grande, Giulia and
Binetti, Giuliano and Papenberg, Goran and Hampel, Harald
and Bailly, Henri and Zetterberg, Henrik and Soininen,
Hilkka and Karlsson, Ida K and Alvarez, Ignacio and
Appollonio, Ildebrando and Giegling, Ina and Skoog, Ingmar
and Saltvedt, Ingvild and Rainero, Innocenzo and Rosas
Allende, Irene and Hort, Jakub and Diehl-Schmid, Janine and
Van Dongen, Jasper and Vidal, Jean-Sebastien and Lehtisalo,
Jenni and Wiltfang, Jens and Thomassen, Jesper Qvist and
Kornhuber, Johannes and Haines, Jonathan L and Vogelgsang,
Jonathan and Pineda, Juan A and Fortea, Juan and Popp,
Julius and Deckert, Jürgen and Bürger, Katharina and
Morgan, Kevin and Fließbach, Klaus and Sleegers, Kristel
and Molina-Porcel, Laura and Kilander, Lena and Weinhold,
Leonie and Farrer, Lindsay A and Wang, Li-San and
Kleineidam, Luca and Farotti, Lucia and Parnetti, Lucilla
and Tremolizzo, Lucio and Hausner, Lucrezia and Benussi,
Luisa and Froelich, Lutz and Ikram, M Arfan and
Deniz-Naranjo, M Candida and Tsolaki, Magda and
Rosende-Roca, Maitée and Löwenmark, Malin and Hulsman,
Marc and Spallazzi, Marco and Pericak-Vance, Margaret A and
Esiri, Margaret and Bernal Sánchez-Arjona, María and
Dalmasso, Maria Carolina and Martínez-Larrad, María Teresa
and Arcaro, Marina and Nöthen, Markus M and
Fernández-Fuertes, Marta and Dichgans, Martin and
Ingelsson, Martin and Herrmann, Martin J and Scherer, Martin
and Vyhnalek, Martin and Kosmidis, Mary H and Yannakoulia,
Mary and Schmid, Matthias and Ewers, Michael and Heneka,
Michael T and Wagner, Michael and Scamosci, Michela and
Kivipelto, Miia and Hiltunen, Mikko and Zulaica, Miren and
Alegret, Montserrat and Fornage, Myriam and Roberto, Natalia
and van Schoor, Natasja M and Seidu, Nazib M and Banaj,
Nerisa and Armstrong, Nicola J and Scarmeas, Nikolaos and
Scherbaum, Norbert and Goldhardt, Oliver and Hanon, Oliver
and Peters, Oliver and Skrobot, Olivia Anna and Quenez,
Olivier and Lerch, Ondrej and Bossù, Paola and Caffarra,
Paolo and Dionigi Rossi, Paolo and Sakka, Paraskevi and
Hoffmann, Per and Holmans, Peter A and Fischer, Peter and
Riederer, Peter and Yang, Qiong and Marshall, Rachel and
Kalaria, Rajesh N and Mayeux, Richard and Vandenberghe, Rik
and Cecchetti, Roberta and Ghidoni, Roberta and
Frikke-Schmidt, Ruth and Sorbi, Sandro and Hägg, Sara and
Engelborghs, Sebastiaan and Helisalmi, Seppo and Botne
Sando, Sigrid and Kern, Silke and Archetti, Silvana and
Boschi, Silvia and Fostinelli, Silvia and Gil, Silvia and
Mendoza, Silvia and Mead, Simon and Ciccone, Simona and
Djurovic, Srdjan and Heilmann-Heimbach, Stefanie and
Riedel-Heller, Steffi and Kuulasmaa, Teemu and Del Ser,
Teodoro and Lebouvier, Thibaud and Polak, Thomas and Ngandu,
Tiia and Grimmer, Timo and Bessi, Valentina and
Escott-Price, Valentina and Giedraitis, Vilmantas and
Deramecourt, Vincent and Maier, Wolfgang and Jian, Xueqiu
and Pijnenburg, Yolande A L and Kehoe, Patrick Gavin and
Garcia-Ribas, Guillermo and Sánchez-Juan, Pascual and
Pastor, Pau and Pérez-Tur, Jordi and Piñol-Ripoll, Gerard
and Lopez de Munain, Adolfo and García-Alberca, Jose María
and Bullido, María J and Álvarez, Victoria and Lleó,
Alberto and Real, Luis M and Mir, Pablo and Medina, Miguel
and Scheltens, Philip and Holstege, Henne and Marquié,
Marta and Sáez, María Eugenia and Carracedo, Ángel and
Amouyel, Philippe and Schellenberg, Gerard D and Williams,
Julie and Seshadri, Sudha and van Duijn, Cornelia M and
Mather, Karen A and Sánchez-Valle, Raquel and
Serrano-Ríos, Manuel and Orellana, Adelina and Tárraga,
Lluís and Blennow, Kaj and Huisman, Martijn and Andreassen,
Ole A and Posthuma, Danielle and Clarimón, Jordi and Boada,
Mercè and van der Flier, Wiesje M and Ramirez, Alfredo and
Lambert, Jean-Charles and van der Lee, Sven J and Ruiz,
Agustín and Smith, A David and Saenz, Aldo and Bizzarro,
Alessandra and Lauria, Alessandra and Vacca, Alessandro and
Solomon, Alina and Anastasiou, Anna and Richardson, Anna and
Boland, Anne and Koivisto, Anne and Daniele, Antonio and
Greco, Antonio and Marianthi, Arnaoutoglou and McGuinness,
Bernadette and Fin, Bertrand and Ferrari, Camilla and
Custodero, Carlo and Ferrarese, Carlo and Ingino, Carlos and
Mangone, Carlos and Reyes Toso, Carlos and Martínez, Carmen
and Cuesta, Carolina and Muchnik, Carolina and Joachim,
Catharine and Ortiz, Cecilia and Besse, Céline and
Johansson, Charlotte and Zoia, Chiara Paola and Laske,
Christoph and Anastasiou, Costas and Palacio, Dana Lis and
Politis, Daniel G and Janowitz, Daniel and Craig, David and
Mann, David M and Neary, David and Jürgen, Deckert and
Daian, Delphine and Belezhanska, Diyana and Kohler, Eduardo
and Castaño, Eduardo M and Koutsouraki, Effrosyni and
Chipi, Elena and De Roeck, Ellen and Costantini, Emanuele
and Vardy, Emma R L C and Piras, Fabrizio and Roveta, Fausto
and Piras, Federica and Prestia, Federico Ariel and Assogna,
Francesca and Salani, Francesca and Sala, Gessica and
Lacidogna, Giordano and Novack, Gisela and Wilcock, Gordon
and Thonberg, Håkan and Kölsch, Heike and Weber, Heike and
Boecker, Henning and Etchepareborda, Ignacio and Piaceri,
Irene and Tuomilehto, Jaakko and Lindström, Jaana and
Laczo, Jan and Johnston, Janet and Deleuze, Jean-François
and Harris, Jenny and Schott, Jonathan M and Priller, Josef
and Bacha, Juan Ignacio and Snowden, Julie and Lisso,
Julieta and Mihova, Kalina Yonkova and Traykov, Latchezar
and Morelli, Laura and Brusco, Luis Ignacio and Rainer,
Malik and Takalo, Mari and Bjerke, Maria and Del Zompo,
Maria and Serpente, Maria and Sanchez Abalos, Mariana and
Rios, Mario and Peltonen, Markku and Herrman, Martin J and
Kosmidis, Mary H and Kohler, Matias and Rojo, Matias and
Jones, Matthew and Orsini, Michela and Medel, Nancy and
Olivar, Natividad and Fox, Nick C and Salvadori, Nicola and
Hooper, Nigel M and Galeano, Pablo and Solis, Patricia and
Bastiani, Patrizia and Mecocci, Patrizia and Passmore, Peter
and Heun, Reinhard and Antikainen, Riitta and Olaso, Robert
and Perneczky, Robert and Germani, Sandra and
López-García, Sara and Love, Seth and Mehrabian, Shima and
Bagnoli, Silvia and Kochen, Silvia and Andreoni, Simona and
Teipel, Stefan and Todd, Stephen and Pickering-Brown, Stuart
and Natunen, Teemu and Tegos, Thomas and Laatikainen, Tiina
and Strandberg, Timo and Polvikoski, Tuomo M and Matoska,
Vaclav and Ciullo, Valentina and Cores, Valeria and
Solfrizzi, Vincenzo and Lisetti, Viviana and Sevillano,
Zulma and Abdelnour, C. and Aguilera, N. and Alarcon, E. and
Alegret, M. and Benaque, A. and Boada, M. and Buendia, M.
and Cañabate, P. and Carracedo, A. and Corbatón-Anchuelo,
A. and de Rojas, I. and Diego, S. and Espinosa, A. and
Gailhajenet, A. and García-González, P. and Gil, S. and
Guitart, M. and González-Pérez, A. and Hernández, I. and
Ibarria, M. and Lafuente, A. and Macias, J. and Maroñas, O.
and Martín, E. and Martínez, M. T. and Marquié, M. and
Mauleón, A. and Montrreal, L. and Moreno-Grau, S. and
Moreno, M. and Orellana, A. and Ortega, G. and Pancho, A.
and Pelejá, E. and Pérez-Cordon, A. and Pineda, J. A. and
Preckler, S. and Quintela, I. and Real, L. M. and
Rosende-Roca, M. and Ruiz, A. and Sáez, M. E. and Sanabria,
A. and Serrano-Rios, M. and Sotolongo-Grau, O. and Tárraga,
L. and Valero, S. and Vargas, L. and Adarmes-Gómez, A. D.
and Alarcón-Martín, E. and Alonso, M. D. and Álvarez, I.
and Álvarez, V. and Amer-Ferrer, G. and Antequera, M. and
Antúnez, C. and Baquero, M. and Bernal, M. and Blesa, R.
and Boada, M. and Buiza-Rueda, D. and Bullido, M. J. and
Burguera, J. A. and Calero, M. and Carrillo, F. and
Carrión-Claro, M. and Casajeros, M. J. and Clarimón, J.
and Cruz-Gamero, J. M. and de Pancorbo, M. M. and de Rojas,
I. and Del Ser, T. and Diez-Fairen, M. and Escuela, R. and
Garrote-Espina, L. and Fortea, J. and Franco-Macías, E. and
Frank-García, A. and García-Alberca, J. M. and Garcia
Madrona, S. and Garcia-Ribas, G. and Gómez-Garre, P. and
Hernández, I. and Hevilla, S. and Jesús, S. and Labrador
Espinosa, M. A. and Lage, C. and Legaz, A. and Lleó, A. and
Lopez de Munain, A. and López-García, S. and
Macias-García, D. and Manzanares, S. and Marín, M. and
Marín-Muñoz, J. and Marín, T. and Marquié, M. and
Martín Montes, A. and Martínez, B. and Martínez, C. and
Martínez, V. and Martínez-Lage Álvarez, P. and Medina, M.
and Mendioroz Iriarte, M. and Menéndez-González, M. and
Mir, P. and Molinuevo, J. L. and Pastor, P. and Pérez Tur,
J. and Periñán-Tocino, T. and Pineda-Sanchez, R. and
Piñol-Ripoll, G. and Rábano, A. and Real de Asúa, D. and
Rodrigo, S. and Rodríguez-Rodríguez, E. and Royo, J. L.
and Ruiz, A. and Sanchez Del Valle Díaz, R. and
Sánchez-Juan, P. and Sastre, I. and Valero, S. and Vicente,
M. P. and Vigo-Ortega, R. and Vivancos, L. and Macleod, C.
and McCracken, C. and Brayne, Carol and Bresner, Catherine
and Grozeva, Detelina and Bellou, Eftychia and Sommerville,
Ewen W and Matthews, F. and Leonenko, Ganna and Menzies,
Georgina and Windle, Gill and Harwood, Janet and Phillips,
Judith and Bennett, K. and Luckuck, Lauren and Clare, Linda
and Woods, Robert and Saad, Salha and Burholt, Vanessa and
Jansen, Iris E and Rongve, Arvid},
collaboration = {contributors, EADB and group, GR@ACE study and consortium,
DEGESCO and IGAP and consortia, PGC-ALZ},
title = {{C}ommon variants in {A}lzheimer's disease and risk
stratification by polygenic risk scores.},
journal = {Nature Communications},
volume = {12},
number = {1},
issn = {2041-1723},
address = {[London]},
publisher = {Nature Publishing Group UK},
reportid = {DZNE-2021-00552},
pages = {3417},
year = {2021},
abstract = {Genetic discoveries of Alzheimer's disease are the drivers
of our understanding, and together with polygenetic risk
stratification can contribute towards planning of feasible
and efficient preventive and curative clinical trials. We
first perform a large genetic association study by merging
all available case-control datasets and by-proxy study
results (discovery n = 409,435 and validation size n =
58,190). Here, we add six variants associated with
Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7,
PLCG2 and two exonic variants in the SHARPIN gene).
Assessment of the polygenic risk score and stratifying by
APOE reveal a 4 to 5.5 years difference in median age at
onset of Alzheimer's disease patients in APOE ɛ4 carriers.
Because of this study, the underlying mechanisms of APP can
be studied to refine the amyloid cascade and the polygenic
risk score provides a tool to select individuals at high
risk of Alzheimer's disease.},
keywords = {Age of Onset / Aged / Aged, 80 and over / Alzheimer
Disease: epidemiology / Alzheimer Disease: genetics /
Alzheimer Disease: pathology / Amyloid beta-Protein
Precursor: genetics / Amyloid beta-Protein Precursor:
metabolism / Apolipoproteins E: genetics / Case-Control
Studies / Cohort Studies / Datasets as Topic / Female /
Follow-Up Studies / Genetic Predisposition to Disease /
Genome-Wide Association Study / Heterozygote / Humans / Male
/ Middle Aged / Multifactorial Inheritance / Polymorphism,
Single Nucleotide / Risk Assessment: methods / Risk Factors
/ APP protein, human (NLM Chemicals) / Amyloid beta-Protein
Precursor (NLM Chemicals) / Apolipoproteins E (NLM
Chemicals)},
cin = {AG Schneider / AG Klockgether / AG Schmid Bonn / AG Simons
/ Biomarker / AG Wagner / AG Endres / AG Wiltfang / AG
Düzel / Clinical Research (Munich) / AG Jessen / Patient
Studies Bonn},
ddc = {500},
cid = {I:(DE-2719)1011305 / I:(DE-2719)1011001 /
I:(DE-2719)1013028 / I:(DE-2719)1110008 / I:(DE-2719)1011301
/ I:(DE-2719)1011201 / I:(DE-2719)1811005 /
I:(DE-2719)1410006 / I:(DE-2719)5000006 / I:(DE-2719)1111015
/ I:(DE-2719)1011102 / I:(DE-2719)1011101},
pnm = {353 - Clinical and Health Care Research (POF4-353) / 351 -
Brain Function (POF4-351)},
pid = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-351},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:34099642},
pmc = {pmc:PMC8184987},
doi = {10.1038/s41467-021-22491-8},
url = {https://pub.dzne.de/record/155272},
}
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