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000155274 0247_ $$2doi$$a10.1002/mds.28639
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000155274 041__ $$aEnglish
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000155274 1001_ $$0P:(DE-HGF)0$$aStuendl, Anne$$b0$$eFirst author
000155274 245__ $$aα-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease.
000155274 260__ $$aNew York, NY$$bWiley$$c2021
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000155274 520__ $$aExtracellular vesicles are small vesicles that are released from many cells, including neurons. α-Synuclein has recently been described in extracellular vesicles derived from the central nervous system and may contribute to the spreading of disease pathology in α-synuclein-related neurodegeneration.We aimed to examine the potential diagnostic value of α-synuclein in plasma extracellular vesicles from patients with Parkinson's disease (PD).Preanalytical variables were studied to establish an optimized assay for preparation of plasma extracellular vesicles and detection of extracellular vesicle-derived α-synuclein. Plasma samples were obtained from 2 independent cohorts. The Tübingen cohort contained 96 patients with PD, 50 patients with dementia with Lewy bodies, 50 patients with progressive supranuclear palsy (PSP), and 42 healthy controls; the Kassel cohort included 47 patients with PD, 43 patients with dementia with Lewy bodies, and 36 controls with secondary parkinsonian syndromes. Extracellular vesicles were prepared from total plasma by size exclusion chromatography and quantified by nanoparticle tracking analysis, α-synuclein content was measured by an electrochemiluminescence assay.α-Synuclein concentration in plasma extracellular vesicles provided the best discrimination between PD, dementia with Lewy bodies, PSP, and healthy controls, with an area under the curve of 0.804 (PD vs dementia with Lewy bodies), 0.815 (PD vs. PSP), and 0.769 (PD vs healthy controls) in the Tübingen cohort. Results were validated in the Kassel cohort.The concentration of α-synuclein in plasma extracellular vesicles may serve as a potential diagnostic biomarker for PD. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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000155274 650_7 $$2Other$$aParkinson's disease
000155274 650_7 $$2Other$$abiomarker
000155274 650_7 $$2Other$$aextracellular vesicles
000155274 650_7 $$2Other$$aplasma
000155274 650_7 $$2Other$$aα-synuclein
000155274 650_2 $$2MeSH$$aBiomarkers
000155274 650_2 $$2MeSH$$aExtracellular Vesicles: pathology
000155274 650_2 $$2MeSH$$aHumans
000155274 650_2 $$2MeSH$$aParkinson Disease: pathology
000155274 650_2 $$2MeSH$$aSupranuclear Palsy, Progressive
000155274 650_2 $$2MeSH$$aalpha-Synuclein
000155274 7001_ $$0P:(DE-2719)2812187$$aKraus, Tanja$$b1
000155274 7001_ $$0P:(DE-2719)2812856$$aChatterjee, Madhurima$$b2
000155274 7001_ $$0P:(DE-2719)2810374$$aZapke, Björn$$b3
000155274 7001_ $$0P:(DE-HGF)0$$aSadowski, Boguslawa$$b4
000155274 7001_ $$0P:(DE-HGF)0$$aMoebius, Wiebke$$b5
000155274 7001_ $$0P:(DE-2719)9000133$$aHobert, Markus A$$b6
000155274 7001_ $$0P:(DE-2719)2812432$$aDeuschle, Christian$$b7
000155274 7001_ $$0P:(DE-2719)2811916$$aBrockmann, Kathrin$$b8$$udzne
000155274 7001_ $$0P:(DE-2719)2810915$$aMaetzler, Walter$$b9
000155274 7001_ $$0P:(DE-2719)9001340$$aMollenhauer, Brit$$b10
000155274 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b11$$eLast author
000155274 773__ $$0PERI:(DE-600)2041249-6$$a10.1002/mds.28639$$gp. mds.28639$$n11$$p2508-2518$$tMovement disorders$$v36$$x1531-8257$$y2021
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