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@ARTICLE{Stuendl:155274,
      author       = {Stuendl, Anne and Kraus, Tanja and Chatterjee, Madhurima
                      and Zapke, Björn and Sadowski, Boguslawa and Moebius,
                      Wiebke and Hobert, Markus A and Deuschle, Christian and
                      Brockmann, Kathrin and Maetzler, Walter and Mollenhauer,
                      Brit and Schneider, Anja},
      title        = {α-{S}ynuclein in {P}lasma-{D}erived {E}xtracellular
                      {V}esicles {I}s a {P}otential {B}iomarker of {P}arkinson's
                      {D}isease.},
      journal      = {Movement disorders},
      volume       = {36},
      number       = {11},
      issn         = {1531-8257},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-00554},
      pages        = {2508-2518},
      year         = {2021},
      abstract     = {Extracellular vesicles are small vesicles that are released
                      from many cells, including neurons. α-Synuclein has
                      recently been described in extracellular vesicles derived
                      from the central nervous system and may contribute to the
                      spreading of disease pathology in α-synuclein-related
                      neurodegeneration.We aimed to examine the potential
                      diagnostic value of α-synuclein in plasma extracellular
                      vesicles from patients with Parkinson's disease
                      (PD).Preanalytical variables were studied to establish an
                      optimized assay for preparation of plasma extracellular
                      vesicles and detection of extracellular vesicle-derived
                      α-synuclein. Plasma samples were obtained from 2
                      independent cohorts. The Tübingen cohort contained 96
                      patients with PD, 50 patients with dementia with Lewy
                      bodies, 50 patients with progressive supranuclear palsy
                      (PSP), and 42 healthy controls; the Kassel cohort included
                      47 patients with PD, 43 patients with dementia with Lewy
                      bodies, and 36 controls with secondary parkinsonian
                      syndromes. Extracellular vesicles were prepared from total
                      plasma by size exclusion chromatography and quantified by
                      nanoparticle tracking analysis, α-synuclein content was
                      measured by an electrochemiluminescence assay.α-Synuclein
                      concentration in plasma extracellular vesicles provided the
                      best discrimination between PD, dementia with Lewy bodies,
                      PSP, and healthy controls, with an area under the curve of
                      0.804 (PD vs dementia with Lewy bodies), 0.815 (PD vs. PSP),
                      and 0.769 (PD vs healthy controls) in the Tübingen cohort.
                      Results were validated in the Kassel cohort.The
                      concentration of α-synuclein in plasma extracellular
                      vesicles may serve as a potential diagnostic biomarker for
                      PD. © 2021 The Authors. Movement Disorders published by
                      Wiley Periodicals LLC on behalf of International Parkinson
                      and Movement Disorder Society.},
      keywords     = {Biomarkers / Extracellular Vesicles: pathology / Humans /
                      Parkinson Disease: pathology / Supranuclear Palsy,
                      Progressive / alpha-Synuclein / Parkinson's disease (Other)
                      / biomarker (Other) / extracellular vesicles (Other) /
                      plasma (Other) / α-synuclein (Other)},
      cin          = {AG Schneider / Biobanking Facility Tübingen / AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)1011305 / I:(DE-2719)1240004 /
                      I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34002893},
      doi          = {10.1002/mds.28639},
      url          = {https://pub.dzne.de/record/155274},
}