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000155279 0247_ $$2doi$$a10.1016/j.nicl.2020.102495
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000155279 1001_ $$0P:(DE-2719)9001515$$aHerdick, Meret-Luise$$b0$$eFirst author$$udzne
000155279 245__ $$aMultimodal MRI analysis of basal forebrain structure and function across the Alzheimer's disease spectrum.
000155279 260__ $$a[Amsterdam u.a.]$$bElsevier$$c2020
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000155279 520__ $$aDysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes.Participants included healthy controls, and subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or AD dementia (ADD) from the multicenter DELCODE study. Resting-state functional MRI (rs-fMRI) and structural MRI data was available for 477 subjects, and a subset of 243 subjects also had DTI data available. Differences between diagnostic groups were investigated using seed-based FC, volumetric, and MD analyses of functionally defined anterior (a-cBF) and posterior (p-cBF) subdivisions of a cytoarchitectonic cBF region-of-interest. In complementary analyses groups were stratified according to amyloid status based on CSF Aβ42/40 biomarker data, which was available in a subset of participants.a-cBF and p-cBF subdivisions showed regional FC profiles that were highly consistent with previously reported patterns, but there were only minimal differences between diagnostic groups. Compared to controls, cBF volumes and MD were significantly different in MCI and ADD but not in SCD. The Aβ42/40 stratified analyses largely matched these results.We reproduced subregion-specific FC profiles of the cBF in a clinical sample spanning the AD spectrum. At least in this multicentric cohort study, cBF-FC did not show marked changes along the AD spectrum, and multimodal MRI did not provide more sensitive measures of AD-related cBF changes compared to volumetry.
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000155279 650_7 $$2Other$$aAlzheimer’s Disease
000155279 650_7 $$2Other$$aCholinergic Basal Forebrain
000155279 650_7 $$2Other$$aFunctional Connectivity
000155279 650_7 $$2Other$$aMean Diffusivity
000155279 650_7 $$2Other$$aResting-state fMRI
000155279 650_7 $$2Other$$aSubjective Cognitive Decline
000155279 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000155279 650_2 $$2MeSH$$aBasal Forebrain: diagnostic imaging
000155279 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging
000155279 650_2 $$2MeSH$$aCohort Studies
000155279 650_2 $$2MeSH$$aHumans
000155279 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000155279 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000155279 7001_ $$0P:(DE-2719)2810283$$aDyrba, Martin$$b1
000155279 7001_ $$0P:(DE-2719)2811931$$aFritz, Hans-Christian J$$b2
000155279 7001_ $$0P:(DE-2719)2811720$$aAltenstein, Slawek$$b3
000155279 7001_ $$0P:(DE-2719)9000476$$aBallarini, Tommaso$$b4
000155279 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b5
000155279 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b6
000155279 7001_ $$0P:(DE-HGF)0$$aCan Cetindag, Arda$$b7
000155279 7001_ $$0P:(DE-HGF)0$$aDechent, Peter$$b8
000155279 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b9
000155279 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b10
000155279 7001_ $$0P:(DE-HGF)0$$aErtl-Wagner, Birgit$$b11
000155279 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b12
000155279 7001_ $$0P:(DE-HGF)0$$aDawn Freiesleben, Silka$$b13
000155279 7001_ $$0P:(DE-2719)2810481$$aFrommann, Ingo$$b14
000155279 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b15
000155279 7001_ $$0P:(DE-HGF)0$$aDylan Haynes, John$$b16
000155279 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael T$$b17
000155279 7001_ $$0P:(DE-HGF)0$$aJanowitz, Daniel$$b18
000155279 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b19
000155279 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b20
000155279 7001_ $$0P:(DE-2719)9000443$$aMetzger, Coraline D$$b21
000155279 7001_ $$0P:(DE-2719)9001516$$aMunk, Mathias H.$$b22$$udzne
000155279 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b23
000155279 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b24
000155279 7001_ $$0P:(DE-2719)2812341$$aRoy, Nina$$b25
000155279 7001_ $$0P:(DE-HGF)0$$aScheffler, Klaus$$b26
000155279 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b27
000155279 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b28
000155279 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b29
000155279 7001_ $$0P:(DE-HGF)0$$aTscheuschler, Maike$$b30
000155279 7001_ $$0P:(DE-2719)9001493$$aVukovich, Ruth$$b31
000155279 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b32
000155279 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b33
000155279 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b34
000155279 7001_ $$0P:(DE-2719)2810708$$aGrothe, Michel J$$b35$$eLast author
000155279 773__ $$0PERI:(DE-600)2701571-3$$a10.1016/j.nicl.2020.102495$$gVol. 28, p. 102495 -$$p102495$$tNeuroImage: Clinical$$v28$$x2213-1582$$y2020
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