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@ARTICLE{Herdick:155279,
      author       = {Herdick, Meret-Luise and Dyrba, Martin and Fritz,
                      Hans-Christian J and Altenstein, Slawek and Ballarini,
                      Tommaso and Brosseron, Frederic and Bürger, Katharina and
                      Can Cetindag, Arda and Dechent, Peter and Dobisch, Laura and
                      Düzel, Emrah and Ertl-Wagner, Birgit and Fliessbach, Klaus
                      and Dawn Freiesleben, Silka and Frommann, Ingo and Glanz,
                      Wenzel and Dylan Haynes, John and Heneka, Michael T and
                      Janowitz, Daniel and Kilimann, Ingo and Laske, Christoph and
                      Metzger, Coraline D and Munk, Mathias H. and Peters, Oliver
                      and Priller, Josef and Roy, Nina and Scheffler, Klaus and
                      Schneider, Anja and Spottke, Annika and Spruth, Eike Jakob
                      and Tscheuschler, Maike and Vukovich, Ruth and Wiltfang,
                      Jens and Jessen, Frank and Teipel, Stefan and Grothe, Michel
                      J},
      title        = {{M}ultimodal {MRI} analysis of basal forebrain structure
                      and function across the {A}lzheimer's disease spectrum.},
      journal      = {NeuroImage: Clinical},
      volume       = {28},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-00559},
      pages        = {102495},
      year         = {2020},
      abstract     = {Dysfunction of the cholinergic basal forebrain (cBF) is
                      associated with cognitive decline in Alzheimer's disease
                      (AD). Multimodal MRI allows for the investigation of cBF
                      changes in-vivo. In this study we assessed alterations in
                      cBF functional connectivity (FC), mean diffusivity (MD), and
                      volume across the spectrum of AD. We further assessed
                      effects of amyloid pathology on these changes.Participants
                      included healthy controls, and subjects with subjective
                      cognitive decline (SCD), mild cognitive impairment (MCI), or
                      AD dementia (ADD) from the multicenter DELCODE study.
                      Resting-state functional MRI (rs-fMRI) and structural MRI
                      data was available for 477 subjects, and a subset of 243
                      subjects also had DTI data available. Differences between
                      diagnostic groups were investigated using seed-based FC,
                      volumetric, and MD analyses of functionally defined anterior
                      (a-cBF) and posterior (p-cBF) subdivisions of a
                      cytoarchitectonic cBF region-of-interest. In complementary
                      analyses groups were stratified according to amyloid status
                      based on CSF Aβ42/40 biomarker data, which was available in
                      a subset of participants.a-cBF and p-cBF subdivisions showed
                      regional FC profiles that were highly consistent with
                      previously reported patterns, but there were only minimal
                      differences between diagnostic groups. Compared to controls,
                      cBF volumes and MD were significantly different in MCI and
                      ADD but not in SCD. The Aβ42/40 stratified analyses largely
                      matched these results.We reproduced subregion-specific FC
                      profiles of the cBF in a clinical sample spanning the AD
                      spectrum. At least in this multicentric cohort study, cBF-FC
                      did not show marked changes along the AD spectrum, and
                      multimodal MRI did not provide more sensitive measures of
                      AD-related cBF changes compared to volumetry.},
      keywords     = {Alzheimer Disease: diagnostic imaging / Basal Forebrain:
                      diagnostic imaging / Cognitive Dysfunction: diagnostic
                      imaging / Cohort Studies / Humans / Magnetic Resonance
                      Imaging / Alzheimer’s Disease (Other) / Cholinergic Basal
                      Forebrain (Other) / Functional Connectivity (Other) / Mean
                      Diffusivity (Other) / Resting-state fMRI (Other) /
                      Subjective Cognitive Decline (Other)},
      cin          = {AG Schneider / AG Teipel / AG Endres / AG Wagner /
                      Biomarker / Clinical Research (Munich) / Patient Studies
                      Bonn / AG Speck / AG Klockgether / Clinical Research
                      Platform (CRP) / AG Priller / Core ICRU / AG Düzel / AG
                      Jessen / AG Wiltfang / AG Gasser / Delcode},
      ddc          = {610},
      cid          = {I:(DE-2719)1011305 / I:(DE-2719)1510100 /
                      I:(DE-2719)1811005 / I:(DE-2719)1011201 / I:(DE-2719)1011301
                      / I:(DE-2719)1111015 / I:(DE-2719)1011101 /
                      I:(DE-2719)1340009 / I:(DE-2719)1011001 / I:(DE-2719)1011401
                      / I:(DE-2719)5000007 / I:(DE-2719)1240005 /
                      I:(DE-2719)5000006 / I:(DE-2719)1011102 / I:(DE-2719)1410006
                      / I:(DE-2719)1210000 / I:(DE-2719)5000034},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 342 -
                      Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-342},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33395986},
      pmc          = {pmc:PMC7689403},
      doi          = {10.1016/j.nicl.2020.102495},
      url          = {https://pub.dzne.de/record/155279},
}