TY  - JOUR
AU  - Grobe-Einsler, Marcus
AU  - Taheri Amin, Arian
AU  - Faber, Jennifer
AU  - Schaprian, Tamara
AU  - Jacobi, Heike
AU  - Schmitz-Hübsch, Tanja
AU  - Diallo, Alhassane
AU  - Tezenas du Montcel, Sophie
AU  - Klockgether, Thomas
TI  - Development of SARA home , a New Video‐Based Tool for the Assessment of Ataxia at Home
JO  - Movement disorders
VL  - 36
IS  - 5
SN  - 1531-8257
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2021-00566
SP  - 1242 - 1246
PY  - 2021
AB  - BackgroundClinical scales such as the Scale for the Assessment and Rating of Ataxia (SARA) cannot be used to study ataxia at home or to assess daily fluctuations. The objective of the current study was to develop a video-based instrument, SARAhome, for measuring ataxia severity easily and independently at home.MethodsBased on feasibility of self-application, we selected 5 SARA items (gait, stance, speech, nose-finger test, fast alternating hand movements) for SARAhome (range, 0–28). We compared SARAhome items with total SARA scores in 526 patients with spinocerebellar ataxia types 1, 2, 3, and 6 from the EUROSCA natural history study. To prospectively validate the SARAhome, we directly compared the self-applied SARAhome and the conventional SARA in 50 ataxia patients. To demonstrate feasibility of independent home recordings in a pilot study, 12 ataxia patients were instructed to obtain a video each morning and evening over a period of 14 days. All videos were rated offline by a trained rater.ResultsSARAhome extracted from the EUROSCA baseline data was highly correlated with conventional SARA (r = 0.9854, P < 0.0001). In the prospective validation study, the SARAhome was highly correlated with the conventional SARA (r = 0.9254, P < 0.0001). Five of 12 participants of the pilot study obtained a complete set of 28 evaluable videos. Seven participants obtained 13–27 videos. The intraindividual differences between the lowest and highest SARAhome scores ranged from 1 to 5.5.ConclusionThe SARAhome and the conventional SARA are highly correlated. Application at home is feasible. There was a considerable degree of intraindividual variability of the SARAhome scores.
KW  - Ataxia: diagnosis
KW  - Cerebellar Ataxia
KW  - Humans
KW  - Pilot Projects
KW  - Prospective Studies
KW  - Severity of Illness Index
KW  - Spinocerebellar Ataxias: diagnosis
LB  - PUB:(DE-HGF)16
C6  - pmid:33433030
C6  - 33433030
DO  - DOI:10.1002/mds.28478
UR  - https://pub.dzne.de/record/155286
ER  -