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@ARTICLE{GrobeEinsler:155286,
      author       = {Grobe-Einsler, Marcus and Taheri Amin, Arian and Faber,
                      Jennifer and Schaprian, Tamara and Jacobi, Heike and
                      Schmitz-Hübsch, Tanja and Diallo, Alhassane and Tezenas du
                      Montcel, Sophie and Klockgether, Thomas},
      title        = {{D}evelopment of {SARA} home , a {N}ew {V}ideo‐{B}ased
                      {T}ool for the {A}ssessment of {A}taxia at {H}ome},
      journal      = {Movement disorders},
      volume       = {36},
      number       = {5},
      issn         = {1531-8257},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-00566},
      pages        = {1242 - 1246},
      year         = {2021},
      abstract     = {BackgroundClinical scales such as the Scale for the
                      Assessment and Rating of Ataxia (SARA) cannot be used to
                      study ataxia at home or to assess daily fluctuations. The
                      objective of the current study was to develop a video-based
                      instrument, SARAhome, for measuring ataxia severity easily
                      and independently at home.MethodsBased on feasibility of
                      self-application, we selected 5 SARA items (gait, stance,
                      speech, nose-finger test, fast alternating hand movements)
                      for SARAhome (range, 0–28). We compared SARAhome items
                      with total SARA scores in 526 patients with spinocerebellar
                      ataxia types 1, 2, 3, and 6 from the EUROSCA natural history
                      study. To prospectively validate the SARAhome, we directly
                      compared the self-applied SARAhome and the conventional SARA
                      in 50 ataxia patients. To demonstrate feasibility of
                      independent home recordings in a pilot study, 12 ataxia
                      patients were instructed to obtain a video each morning and
                      evening over a period of 14 days. All videos were rated
                      offline by a trained rater.ResultsSARAhome extracted from
                      the EUROSCA baseline data was highly correlated with
                      conventional SARA (r = 0.9854, P < 0.0001). In the
                      prospective validation study, the SARAhome was highly
                      correlated with the conventional SARA (r = 0.9254, P
                      < 0.0001). Five of 12 participants of the pilot study
                      obtained a complete set of 28 evaluable videos. Seven
                      participants obtained 13–27 videos. The intraindividual
                      differences between the lowest and highest SARAhome scores
                      ranged from 1 to 5.5.ConclusionThe SARAhome and the
                      conventional SARA are highly correlated. Application at home
                      is feasible. There was a considerable degree of
                      intraindividual variability of the SARAhome scores.},
      keywords     = {Ataxia: diagnosis / Cerebellar Ataxia / Humans / Pilot
                      Projects / Prospective Studies / Severity of Illness Index /
                      Spinocerebellar Ataxias: diagnosis},
      cin          = {AG Klockgether / Patient studies, Bonn / AG Spottke},
      ddc          = {610},
      cid          = {I:(DE-2719)1011001 / I:(DE-2719)1011101 /
                      I:(DE-2719)1011103},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)SCA-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33433030},
      pubmed       = {33433030},
      doi          = {10.1002/mds.28478},
      url          = {https://pub.dzne.de/record/155286},
}