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@ARTICLE{Andersson:155338,
author = {Andersson, Robin and Gebhard, Claudia and Miguel-Escalada,
Irene and Hoof, Ilka and Bornholdt, Jette and Boyd, Mette
and Chen, Yun and Zhao, Xiaobei and Schmidl, Christian and
Suzuki, Takahiro and Ntini, Evgenia and Arner, Erik and
Valen, Eivind and Li, Kang and Schwarzfischer, Lucia and
Glatz, Dagmar and Raithel, Johanna and Lilje, Berit and
Rapin, Nicolas and Bagger, Frederik Otzen and Jørgensen,
Mette and Andersen, Peter Refsing and Bertin, Nicolas and
Rackham, Owen and Burroughs, A Maxwell and Baillie, J
Kenneth and Ishizu, Yuri and Shimizu, Yuri and Furuhata,
Erina and Maeda, Shiori and Negishi, Yutaka and Mungall,
Christopher J and Meehan, Terrence F and Lassmann, Timo and
Itoh, Masayoshi and Kawaji, Hideya and Kondo, Naoto and
Kawai, Jun and Lennartsson, Andreas and Daub, Carsten O and
Heutink, Peter and Hume, David A and Jensen, Torben Heick
and Suzuki, Harukazu and Hayashizaki, Yoshihide and Müller,
Ferenc and Forrest, Alistair R R and Carninci, Piero and
Rehli, Michael and Sandelin, Albin and Forrest, Alistair R R
and Kawaji, Hideya and Rehli, Michael and Baillie, J Kenneth
and de Hoon, Michiel J L and Haberle, Vanja and Lassmann,
Timo and Kulakovskiy, Ivan V and Lizio, Marina and Itoh,
Masayoshi and Andersson, Robin and Mungall, Christoher J and
Meehan, Terrence F and Schmeier, Sebastian and Bertin,
Nicolas and Jørgensen, Mette and Dimont, Emmanuel and
Arner, Erik and Schmid, Christian and Schaefer, Ulf and
Medvedeva, Yulia A and Plessy, Charles and Vitezic, Morana
and Severin, James and Semple, Colin A and Ishizu, Yuri and
Young, Robert S and Francescatto, Margherita and Alam,
Intikhab and Albanese, Davide and Altschuler, Gabriel M and
Arakawa, Takahiro and Archer, John A C and Arner, Peter and
Babina, Magda and Rennie, Sarah and Balwierz, Piotr J and
Beckhouse, Anthony G and Pradhan-Bhatt, Swati and Blake,
Judith A and Blumenthal, Antje and Bodega, Beatrice and
Bonetti, Alessandro and Briggs, James and Brombacher, Frank
and Burroughs, A Maxwell and Califano, Andrea and
Cannistracti, Carlo V and Carbajo, Daniel and Chen, Yun and
Chierici, Marco and Ciani, Yari and Clevers, Hans C and
Dalla, Emiliano and Davis, Carrie A and Detmar, Michael and
Diehl, Alexander D and Dohi, Taeko and Drabløs, Finn and
Edge, Albert S B and Edinger, Matthias and Ekwall, Karl and
Endoh, Mitsuhiro and Enomoto, Hideki and Fagiolini, Michela
and Fairbairn, Lynsey and Fang, Hai and Farach-Carson, Mary
C and Faulkner, Geoffrey J and Favorov, Alexander V and
Fisher, Malcolm E and Frith, Martin C and Fujita, Rie and
Fukuda, Shiro and Furlanello, Cesare and Furuno, Masaaki and
Furusawa, Jun-ichi and Geijtenbeek, Teunis B and Gibson,
Andrew P and Gingeras, Thomas and Goldowitz, Daniel and
Gough, Julian and Guhl, Sven and Guler, Reto and Gustincich,
Stefano and Ha, Thomas J and Hamaguchi, Masahide and Hara,
Mitsuko and Harbers, Matthias and Harshbarger, Jayson and
Hasegawa, Akira and Hasegawa, Yuki and Hashimoto, Takehiro
and Herlyn, Meenhard and Hitchens, Kelly J and Ho Sui,
Shannan J and Hofman, Oliver M and Hoof, Ilka and Hori, Fumi
and Huminiecki, Lukasz and Iida, Kei and Ikawa, Tomokatsu
and Jankovic, Boris R and Jia, Hui and Joshi, Anagha and
Jurman, Giuseppe and Kaczkowski, Bogumil and Kai, Chieko and
Kaida, Kaoru and Kaiho, Ai and Kajiyama, Kazuhiro and
Kanamori-Katayama, Mutsumi and Kasianov, Artem S and
Kasukawa, Takeya and Katayama, Shintaro and Kato, Sachi and
Kawaguchi, Shuji and Kawamoto, Hiroshi and Kawamura, Yuki I
and Kawashima, Tsugumi and Kempfle, Judith S and Kenna, Tony
J and Kere, Juha and Khachigian, Levon M and Kitamura,
Toshio and Klinken, S Peter and Knox, Alan J and Kojima,
Miki and Kojima, Soichi and Kondo, Naoto and Koseki,
Haruhiko and Koyasu, Shigeo and Krampitz, Sarah and
Kubosaki, Atsutaka and Kwon, Andrew T and Laros, Jeroen F J
and Lee, Weonju and Lennartsson, Andreas and Li, Kang and
Lilje, Berit and Lipovich, Leonard and Mackay-Sim, Alan and
Manabe, Ri-ichiroh and Mar, Jessica C and Marchand, Benoit
and Mathelier, Anthony and Mejhert, Niklas and Meynert,
Alison and Mizuno, Yosuke and de Lima Morais, David A and
Morikawa, Hiromasa and Morimoto, Mitsuru and Moro, Kazuyo
and Motakis, Efthymios and Motohashi, Hozumi and Mummery,
Christine L and Murata, Mitsuyoshi and Nagao-Sato, Sayaka
and Nakachi, Yutaka and Nakahara, Fumio and Nakamura,
Toshiyuki and Nakamura, Yukio and Nakazato, Kenichi and van
Nimwegen, Erik and Ninomiya, Noriko and Nishiyori, Hiromi
and Noma, Shohei and Nozaki, Tadasuke and Ogishima, Soichi
and Ohkura, Naganari and Ohmiya, Hiroko and Ohno, Hiroshi
and Onshima, Mitsuhiro and Okada-Hatakeyama, Mariko and
Okazaki, Yasushi and Orlando, Valerie and Ovchinnikov,
Dmitry A and Pain, Arnab and Passier, Robert and Patrikakis,
Margaret and Persson, Helena and Piazza, Silvano and
Prendergast, James G D and Rackham, Owen J L and Ramilowski,
Jordan A and Rashid, Mamoon and Ravasi, Timothy and Rizzu,
Patrizia and Roncador, Marco and Roy, Sugata and Rye, Morten
B and Saijyo, Eri and Sajantila, Antti and Saka, Akiko and
Sakaguchi, Shimon and Sakai, Mizuho and Sato, Hiroki and
Satoh, Hironori and Savvi, Suzana and Saxena, Alka and
Schneider, Claudio and Schultes, Erik A and Schultz-Tanzil,
Gudula G and Schwegmann, Anita and Sengstag, Thierry and
Sheng, Guojun and Shimoji, Hisashi and Shimoni, Yishai and
Shin, Jay W and Simon, Christophe and Sugiyama, Daisuke and
Sugiyama, Takaaki and Suzuki, Masanori and Suzuki, Naoko and
Swoboda, Rolf K and 't Hoen, Peter A C and Tagami, Michihira
and Takahashi, Naoko and Takai, Jun and Tanaka, Hiroshi and
Tatsukawa, Hideki and Tatum, Zuotian and Thompson, Mark and
Toyoda, Hiroo and Toyodo, Tetsuro and Valen, Eivind and van
de Wetering, Marc and van den Berg, Linda M and Verardo,
Roberto and Vijayan, Dipti and Vorontsov, Ilya E and
Wasserman, Wyeth W and Watanabe, Shoko and Wells, Christine
A and Winteringham, Louise N and Wolvetang, Ernst and Wood,
Emily J and Yamaguchi, Yoko and Yamamoto, Masayuki and
Yoneda, Misako and Yonekura, Yohei and Yoshida, Shigehiro
and Zabierowski, Susan E and Zhang, Peter G and Zhao,
Xiaobei and Zucchelli, Silvia and Summers, Kim M and Suzuki,
Harukazu and Daub, Carsten O and Kawai, Jun and Heutink,
Peter and Hide, Winston and Freeman, Tom C and Lenhard,
Boris and Bajic, Vladimir B and Taylor, Martin S and Makeev,
Vsevolod J and Sandelin, Allbin and Hume, David A and
Carninci, Piero and Hayashizaki, Yoshihide},
title = {{A}n atlas of active enhancers across human cell types and
tissues.},
journal = {Nature},
volume = {507},
number = {7493},
issn = {1476-4687},
address = {London [u.a.]},
publisher = {Nature Publ. Group},
reportid = {DZNE-2021-00605},
pages = {455 - 461},
year = {2014},
abstract = {Enhancers control the correct temporal and
cell-type-specific activation of gene expression in
multicellular eukaryotes. Knowing their properties,
regulatory activity and targets is crucial to understand the
regulation of differentiation and homeostasis. Here we use
the FANTOM5 panel of samples, covering the majority of human
tissues and cell types, to produce an atlas of active, in
vivo-transcribed enhancers. We show that enhancers share
properties with CpG-poor messenger RNA promoters but produce
bidirectional, exosome-sensitive, relatively short unspliced
RNAs, the generation of which is strongly related to
enhancer activity. The atlas is used to compare regulatory
programs between different cells at unprecedented depth, to
identify disease-associated regulatory single nucleotide
polymorphisms, and to classify cell-type-specific and
ubiquitous enhancers. We further explore the utility of
enhancer redundancy, which explains gene expression strength
rather than expression patterns. The online FANTOM5 enhancer
atlas represents a unique resource for studies on
cell-type-specific enhancers and gene regulation.},
keywords = {Atlases as Topic / Cell Line / Cells, Cultured / Cluster
Analysis / Enhancer Elements, Genetic: genetics / Gene
Expression Regulation: genetics / Genetic Predisposition to
Disease: genetics / HeLa Cells / Humans / Molecular Sequence
Annotation / Organ Specificity / Polymorphism, Single
Nucleotide: genetics / Promoter Regions, Genetic: genetics /
RNA, Messenger: biosynthesis / RNA, Messenger: genetics /
Transcription Initiation Site / Transcription Initiation,
Genetic / RNA, Messenger (NLM Chemicals)},
ddc = {500},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:24670763},
pmc = {pmc:PMC5215096},
doi = {10.1038/nature12787},
url = {https://pub.dzne.de/record/155338},
}
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