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000155357 1001_ $$0P:(DE-2719)2811868$$aSippel, Daniel$$b0$$udzne
000155357 245__ $$aDisruption of NREM sleep and sleep-related spatial memory consolidation in mice lacking adult hippocampal neurogenesis.
000155357 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2020
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000155357 520__ $$aCellular plasticity at the structural level and sleep at the behavioural level are both essential for memory formation. The link between the two is not well understood. A functional connection between adult neurogenesis and hippocampus-dependent memory consolidation during NREM sleep has been hypothesized but not experimentally shown. Here, we present evidence that during a three-day learning session in the Morris water maze task a genetic knockout model of adult neurogenesis (Cyclin D2-/-) showed changes in sleep macro- and microstructure. Sleep EEG analyses revealed a lower total sleep time and NREM fraction in Cyclin D2-/- mice as well as an impairment of sleep specific neuronal oscillations that are associated with memory consolidation. Better performance in the memory task was associated with specific sleep parameters in wild-type, but not in Cyclin D2-/- mice. In wild-type animals the number of proliferating cells correlated with the amount of NREM sleep. The lack of adult neurogenesis led to changes in sleep architecture and oscillations that represent the dialog between hippocampus and neocortex during sleep. We suggest that adult neurogenesis-as a key event of hippocampal plasticity-might play an important role for sleep-dependent memory consolidation and modulates learning-induced changes of sleep macro- and microstructure.
000155357 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
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000155357 650_7 $$2NLM Chemicals$$aCyclin D2
000155357 650_2 $$2MeSH$$aAnimals
000155357 650_2 $$2MeSH$$aCyclin D2: metabolism
000155357 650_2 $$2MeSH$$aElectroencephalography: methods
000155357 650_2 $$2MeSH$$aHippocampus: metabolism
000155357 650_2 $$2MeSH$$aHippocampus: physiology
000155357 650_2 $$2MeSH$$aMaze Learning: physiology
000155357 650_2 $$2MeSH$$aMemory Consolidation: physiology
000155357 650_2 $$2MeSH$$aMice
000155357 650_2 $$2MeSH$$aMice, Inbred C57BL
000155357 650_2 $$2MeSH$$aNeurogenesis: physiology
000155357 650_2 $$2MeSH$$aNeurons: metabolism
000155357 650_2 $$2MeSH$$aNeurons: physiology
000155357 650_2 $$2MeSH$$aPolysomnography: methods
000155357 650_2 $$2MeSH$$aSleep: physiology
000155357 650_2 $$2MeSH$$aSleep Stages: physiology
000155357 650_2 $$2MeSH$$aSleep, Slow-Wave: physiology
000155357 650_2 $$2MeSH$$aSpatial Memory: physiology
000155357 7001_ $$aSchwabedal, J.$$b1
000155357 7001_ $$aSnyder, J. C.$$b2
000155357 7001_ $$00000-0002-2853-1167$$aOyanedel, C. N.$$b3
000155357 7001_ $$0P:(DE-2719)2811412$$aBernas, Stefanie$$b4$$udzne
000155357 7001_ $$0P:(DE-2719)2810535$$aGarthe, A.$$b5$$udzne
000155357 7001_ $$aTröndle, A.$$b6
000155357 7001_ $$0P:(DE-2719)9000306$$aStorch, A.$$b7$$udzne
000155357 7001_ $$0P:(DE-2719)2000011$$aKempermann, G.$$b8$$udzne
000155357 7001_ $$0P:(DE-2719)2812107$$aBrandt, Daniel Moritz$$b9$$eLast author$$udzne
000155357 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-020-72362-3$$gVol. 10, no. 1, p. 16467$$n1$$p16467$$tScientific reports$$v10$$x2045-2322$$y2020
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