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@ARTICLE{Sippel:155357,
      author       = {Sippel, Daniel and Schwabedal, J. and Snyder, J. C. and
                      Oyanedel, C. N. and Bernas, Stefanie and Garthe, A. and
                      Tröndle, A. and Storch, A. and Kempermann, G. and Brandt,
                      Daniel Moritz},
      title        = {{D}isruption of {NREM} sleep and sleep-related spatial
                      memory consolidation in mice lacking adult hippocampal
                      neurogenesis.},
      journal      = {Scientific reports},
      volume       = {10},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2021-00622},
      pages        = {16467},
      year         = {2020},
      abstract     = {Cellular plasticity at the structural level and sleep at
                      the behavioural level are both essential for memory
                      formation. The link between the two is not well understood.
                      A functional connection between adult neurogenesis and
                      hippocampus-dependent memory consolidation during NREM sleep
                      has been hypothesized but not experimentally shown. Here, we
                      present evidence that during a three-day learning session in
                      the Morris water maze task a genetic knockout model of adult
                      neurogenesis (Cyclin D2-/-) showed changes in sleep macro-
                      and microstructure. Sleep EEG analyses revealed a lower
                      total sleep time and NREM fraction in Cyclin D2-/- mice as
                      well as an impairment of sleep specific neuronal
                      oscillations that are associated with memory consolidation.
                      Better performance in the memory task was associated with
                      specific sleep parameters in wild-type, but not in Cyclin
                      D2-/- mice. In wild-type animals the number of proliferating
                      cells correlated with the amount of NREM sleep. The lack of
                      adult neurogenesis led to changes in sleep architecture and
                      oscillations that represent the dialog between hippocampus
                      and neocortex during sleep. We suggest that adult
                      neurogenesis-as a key event of hippocampal plasticity-might
                      play an important role for sleep-dependent memory
                      consolidation and modulates learning-induced changes of
                      sleep macro- and microstructure.},
      keywords     = {Animals / Cyclin D2: metabolism / Electroencephalography:
                      methods / Hippocampus: metabolism / Hippocampus: physiology
                      / Maze Learning: physiology / Memory Consolidation:
                      physiology / Mice / Mice, Inbred C57BL / Neurogenesis:
                      physiology / Neurons: metabolism / Neurons: physiology /
                      Polysomnography: methods / Sleep: physiology / Sleep Stages:
                      physiology / Sleep, Slow-Wave: physiology / Spatial Memory:
                      physiology / Cyclin D2 (NLM Chemicals)},
      cin          = {AG Kempermann 1 / AG Garthe 1 / AG Storch 2 Rostock / AG
                      Donix},
      ddc          = {600},
      cid          = {I:(DE-2719)1710001 / I:(DE-2719)1740001 /
                      I:(DE-2719)5000014 / I:(DE-2719)1710008},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 342 -
                      Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33020501},
      pmc          = {pmc:PMC7536189},
      doi          = {10.1038/s41598-020-72362-3},
      url          = {https://pub.dzne.de/record/155357},
}