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000155387 037__ $$aDZNE-2021-00627
000155387 041__ $$aEnglish
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000155387 1001_ $$00000-0002-9735-5152$$aJoseph-Mathurin, Nelly$$b0
000155387 245__ $$aLongitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease.
000155387 260__ $$a[S.l.]$$bOvid$$c2021
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000155387 520__ $$aTo investigate the inherent clinical risks associated with the presence of cerebral microhemorrhages (CMHs) or cerebral microbleeds and characterize individuals at high risk for developing hemorrhagic amyloid-related imaging abnormality (ARIA-H), we longitudinally evaluated families with dominantly inherited Alzheimer disease (DIAD).Mutation carriers (n = 310) and noncarriers (n = 201) underwent neuroimaging, including gradient echo MRI sequences to detect CMHs, and neuropsychological and clinical assessments. Cross-sectional and longitudinal analyses evaluated relationships between CMHs and neuroimaging and clinical markers of disease.Three percent of noncarriers and 8% of carriers developed CMHs primarily located in lobar areas. Carriers with CMHs were older, had higher diastolic blood pressure and Hachinski ischemic scores, and more clinical, cognitive, and motor impairments than those without CMHs. APOE ε4 status was not associated with the prevalence or incidence of CMHs. Prevalent or incident CMHs predicted faster change in Clinical Dementia Rating although not composite cognitive measure, cortical thickness, hippocampal volume, or white matter lesions. Critically, the presence of 2 or more CMHs was associated with a significant risk for development of additional CMHs over time (8.95 ± 10.04 per year).Our study highlights factors associated with the development of CMHs in individuals with DIAD. CMHs are a part of the underlying disease process in DIAD and are significantly associated with dementia. This highlights that in participants in treatment trials exposed to drugs, which carry the risk of ARIA-H as a complication, it may be challenging to separate natural incidence of CMHs from drug-related CMHs.
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000155387 650_2 $$2MeSH$$aAdult
000155387 650_2 $$2MeSH$$aAlzheimer Disease: complications
000155387 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000155387 650_2 $$2MeSH$$aBrain: pathology
000155387 650_2 $$2MeSH$$aCerebral Hemorrhage: epidemiology
000155387 650_2 $$2MeSH$$aCerebral Hemorrhage: etiology
000155387 650_2 $$2MeSH$$aCerebral Hemorrhage: pathology
000155387 650_2 $$2MeSH$$aFemale
000155387 650_2 $$2MeSH$$aHumans
000155387 650_2 $$2MeSH$$aLongitudinal Studies
000155387 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000155387 650_2 $$2MeSH$$aMale
000155387 650_2 $$2MeSH$$aMiddle Aged
000155387 7001_ $$aWang, Guoqiao$$b1
000155387 7001_ $$aKantarci, Kejal$$b2
000155387 7001_ $$aJack, Clifford R$$b3
000155387 7001_ $$aMcDade, Eric$$b4
000155387 7001_ $$aHassenstab, Jason$$b5
000155387 7001_ $$aBlazey, Tyler M$$b6
000155387 7001_ $$aGordon, Brian A$$b7
000155387 7001_ $$aSu, Yi$$b8
000155387 7001_ $$aChen, Gengsheng$$b9
000155387 7001_ $$aMassoumzadeh, Parinaz$$b10
000155387 7001_ $$aHornbeck, Russ C$$b11
000155387 7001_ $$aAllegri, Ricardo F$$b12
000155387 7001_ $$aAnces, Beau M$$b13
000155387 7001_ $$aBerman, Sarah B$$b14
000155387 7001_ $$00000-0002-5125-8226$$aBrickman, Adam M$$b15
000155387 7001_ $$aBrooks, William S$$b16
000155387 7001_ $$00000-0001-7833-616X$$aCash, David M$$b17
000155387 7001_ $$aChhatwal, Jasmeer P$$b18
000155387 7001_ $$aChui, Helena C$$b19
000155387 7001_ $$aCorreia, Stephen$$b20
000155387 7001_ $$00000-0002-0276-2899$$aCruchaga, Carlos$$b21
000155387 7001_ $$aFarlow, Martin R$$b22
000155387 7001_ $$aFox, Nick C$$b23
000155387 7001_ $$00000-0003-0602-6319$$aFulham, Michael$$b24
000155387 7001_ $$aGhetti, Bernardino$$b25
000155387 7001_ $$aGraff-Radford, Neill R$$b26
000155387 7001_ $$aJohnson, Keith A$$b27
000155387 7001_ $$00000-0002-6854-5547$$aKarch, Celeste M$$b28
000155387 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b29$$udzne
000155387 7001_ $$aLee, Athene K W$$b30
000155387 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b31$$udzne
000155387 7001_ $$aMasters, Colin L$$b32
000155387 7001_ $$aNoble, James M$$b33
000155387 7001_ $$aO'Connor, Antoinette$$b34
000155387 7001_ $$aPerrin, Richard J$$b35
000155387 7001_ $$aPreboske, Gregory M$$b36
000155387 7001_ $$aRingman, John M$$b37
000155387 7001_ $$aRowe, Christopher C$$b38
000155387 7001_ $$aSalloway, Stephen$$b39
000155387 7001_ $$00000-0002-1376-8532$$aSaykin, Andrew J$$b40
000155387 7001_ $$00000-0003-2967-9662$$aSchofield, Peter R$$b41
000155387 7001_ $$aShimada, Hiroyuki$$b42
000155387 7001_ $$00000-0003-1027-1712$$aShoji, Mikio$$b43
000155387 7001_ $$aSuzuki, Kazushi$$b44
000155387 7001_ $$aVillemagne, Victor L$$b45
000155387 7001_ $$aXiong, Chengjie$$b46
000155387 7001_ $$0P:(DE-2719)9000355$$aYakushev, Igor$$b47$$udzne
000155387 7001_ $$aMorris, John C$$b48
000155387 7001_ $$00000-0002-7729-1702$$aBateman, Randall J$$b49
000155387 7001_ $$aBenzinger, Tammie L S$$b50
000155387 7001_ $$0P:(DE-HGF)0$$aNetwork, Dominantly Inherited Alzheimer$$b51$$eCollaboration Author
000155387 773__ $$0PERI:(DE-600)1491874-2$$a10.1212/WNL.0000000000011542$$gVol. 96, no. 12, p. e1632 - e1645$$n12$$pe1632 - e1645$$tNeurology$$v96$$x1526-632X$$y2021
000155387 8564_ $$uhttps://n.neurology.org/content/96/12/e1632.long
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