TY  - JOUR
AU  - Joseph-Mathurin, Nelly
AU  - Wang, Guoqiao
AU  - Kantarci, Kejal
AU  - Jack, Clifford R
AU  - McDade, Eric
AU  - Hassenstab, Jason
AU  - Blazey, Tyler M
AU  - Gordon, Brian A
AU  - Su, Yi
AU  - Chen, Gengsheng
AU  - Massoumzadeh, Parinaz
AU  - Hornbeck, Russ C
AU  - Allegri, Ricardo F
AU  - Ances, Beau M
AU  - Berman, Sarah B
AU  - Brickman, Adam M
AU  - Brooks, William S
AU  - Cash, David M
AU  - Chhatwal, Jasmeer P
AU  - Chui, Helena C
AU  - Correia, Stephen
AU  - Cruchaga, Carlos
AU  - Farlow, Martin R
AU  - Fox, Nick C
AU  - Fulham, Michael
AU  - Ghetti, Bernardino
AU  - Graff-Radford, Neill R
AU  - Johnson, Keith A
AU  - Karch, Celeste M
AU  - Laske, Christoph
AU  - Lee, Athene K W
AU  - Levin, Johannes
AU  - Masters, Colin L
AU  - Noble, James M
AU  - O'Connor, Antoinette
AU  - Perrin, Richard J
AU  - Preboske, Gregory M
AU  - Ringman, John M
AU  - Rowe, Christopher C
AU  - Salloway, Stephen
AU  - Saykin, Andrew J
AU  - Schofield, Peter R
AU  - Shimada, Hiroyuki
AU  - Shoji, Mikio
AU  - Suzuki, Kazushi
AU  - Villemagne, Victor L
AU  - Xiong, Chengjie
AU  - Yakushev, Igor
AU  - Morris, John C
AU  - Bateman, Randall J
AU  - Benzinger, Tammie L S
TI  - Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease.
JO  - Neurology
VL  - 96
IS  - 12
SN  - 1526-632X
CY  - [S.l.]
PB  - Ovid
M1  - DZNE-2021-00627
SP  - e1632 - e1645
PY  - 2021
AB  - To investigate the inherent clinical risks associated with the presence of cerebral microhemorrhages (CMHs) or cerebral microbleeds and characterize individuals at high risk for developing hemorrhagic amyloid-related imaging abnormality (ARIA-H), we longitudinally evaluated families with dominantly inherited Alzheimer disease (DIAD).Mutation carriers (n = 310) and noncarriers (n = 201) underwent neuroimaging, including gradient echo MRI sequences to detect CMHs, and neuropsychological and clinical assessments. Cross-sectional and longitudinal analyses evaluated relationships between CMHs and neuroimaging and clinical markers of disease.Three percent of noncarriers and 8
KW  - Adult
KW  - Alzheimer Disease: complications
KW  - Alzheimer Disease: pathology
KW  - Brain: pathology
KW  - Cerebral Hemorrhage: epidemiology
KW  - Cerebral Hemorrhage: etiology
KW  - Cerebral Hemorrhage: pathology
KW  - Female
KW  - Humans
KW  - Longitudinal Studies
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
LB  - PUB:(DE-HGF)16
C6  - pmid:33495373
C2  - pmc:PMC8032370
DO  - DOI:10.1212/WNL.0000000000011542
UR  - https://pub.dzne.de/record/155387
ER  -