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@ARTICLE{Aly:155448,
      author       = {Aly, Lilian and Strauß, Eva-Maria and Feucht, Nikolaus and
                      Weiß, Isabella and Berthele, Achim and Mitsdoerffer, Meike
                      and Haass, Christian and Hemmer, Bernhard and Maier, Mathias
                      and Korn, Thomas and Knier, Benjamin},
      title        = {{O}ptical coherence tomography angiography indicates
                      subclinical retinal disease in neuromyelitis optica spectrum
                      disorders.},
      journal      = {Multiple sclerosis journal},
      volume       = {28},
      number       = {4},
      issn         = {1477-0970},
      address      = {London},
      publisher    = {Sage},
      reportid     = {DZNE-2021-00654},
      pages        = {522-531},
      year         = {2022},
      abstract     = {Neuromyelitis optica spectrum disorders (NMOSD) are
                      neuroinflammatory diseases of the central nervous system.
                      Patients suffer from recurring relapses and it is unclear
                      whether relapse-independent disease activity occurs and
                      whether this is of clinical relevance.To detect
                      disease-specific alterations of the retinal vasculature that
                      reflect disease activity during NMOSD.Cross-sectional
                      analysis of 16 patients with NMOSD, 21 patients with
                      relapsing-remitting multiple sclerosis, and 21 healthy
                      controls using retinal optical coherence tomography (OCT),
                      optical coherence tomography angiography (OCT-A),
                      measurement of glial fibrillary acidic protein (GFAP) serum
                      levels, and assessment of visual acuity.Patients with NMOSD
                      but not multiple sclerosis revealed lower foveal thickness
                      (FT) (p = 0.02) measures and an increase of the foveal
                      avascular zone (FAZ) (p = 0.02) compared to healthy controls
                      independent to optic neuritis. Reduced FT (p = 0.01),
                      enlarged FAZ areas (p = 0.0001), and vessel loss of the
                      superficial vascular complex (p = 0.01) were linked to
                      higher serum GFAP levels and superficial vessel loss was
                      associated with worse visual performance in patients with
                      NMOSD irrespective of optic neuritis.Subclinical parafoveal
                      retinal vessel loss might occur during NMOSD and might be
                      linked to astrocyte damage and poor visual performance.
                      OCT-A may be a tool to study subclinical disease activity
                      during NMOSD.},
      keywords     = {Angiography / Cross-Sectional Studies / Humans /
                      Neuromyelitis Optica: diagnosis / Retinal Diseases /
                      Tomography, Optical Coherence: methods / Neuromyelitis
                      optica spectrum disorders (Other) / astrocytes (Other) /
                      biomarker (Other) / disease activity (Other) / optical
                      coherence tomography angiography (Other)},
      cin          = {AG Haass},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8961243},
      pubmed       = {pmid:34259579},
      doi          = {10.1177/13524585211028831},
      url          = {https://pub.dzne.de/record/155448},
}