Home > Publications Database > Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders. > print

001     155448
005     20240302115203.0
024 7 _ |a pmc:PMC8961243
|2 pmc
024 7 _ |a 10.1177/13524585211028831
|2 doi
024 7 _ |a pmid:34259579
|2 pmid
024 7 _ |a 1352-4585
|2 ISSN
024 7 _ |a 1477-0970
|2 ISSN
024 7 _ |a altmetric:109530659
|2 altmetric
037 _ _ |a DZNE-2021-00654
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Aly, Lilian
|b 0
245 _ _ |a Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders.
260 _ _ |a London
|c 2022
|b Sage
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1709306031_5354
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Neuromyelitis optica spectrum disorders (NMOSD) are neuroinflammatory diseases of the central nervous system. Patients suffer from recurring relapses and it is unclear whether relapse-independent disease activity occurs and whether this is of clinical relevance.To detect disease-specific alterations of the retinal vasculature that reflect disease activity during NMOSD.Cross-sectional analysis of 16 patients with NMOSD, 21 patients with relapsing-remitting multiple sclerosis, and 21 healthy controls using retinal optical coherence tomography (OCT), optical coherence tomography angiography (OCT-A), measurement of glial fibrillary acidic protein (GFAP) serum levels, and assessment of visual acuity.Patients with NMOSD but not multiple sclerosis revealed lower foveal thickness (FT) (p = 0.02) measures and an increase of the foveal avascular zone (FAZ) (p = 0.02) compared to healthy controls independent to optic neuritis. Reduced FT (p = 0.01), enlarged FAZ areas (p = 0.0001), and vessel loss of the superficial vascular complex (p = 0.01) were linked to higher serum GFAP levels and superficial vessel loss was associated with worse visual performance in patients with NMOSD irrespective of optic neuritis.Subclinical parafoveal retinal vessel loss might occur during NMOSD and might be linked to astrocyte damage and poor visual performance. OCT-A may be a tool to study subclinical disease activity during NMOSD.
536 _ _ |a 352 - Disease Mechanisms (POF4-352)
|0 G:(DE-HGF)POF4-352
|c POF4-352
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Neuromyelitis optica spectrum disorders
|2 Other
650 _ 7 |a astrocytes
|2 Other
650 _ 7 |a biomarker
|2 Other
650 _ 7 |a disease activity
|2 Other
650 _ 7 |a optical coherence tomography angiography
|2 Other
650 _ 2 |a Angiography
|2 MeSH
650 _ 2 |a Cross-Sectional Studies
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Neuromyelitis Optica: diagnosis
|2 MeSH
650 _ 2 |a Retinal Diseases
|2 MeSH
650 _ 2 |a Tomography, Optical Coherence: methods
|2 MeSH
700 1 _ |a Strauß, Eva-Maria
|b 1
700 1 _ |a Feucht, Nikolaus
|b 2
700 1 _ |a Weiß, Isabella
|b 3
700 1 _ |a Berthele, Achim
|b 4
700 1 _ |a Mitsdoerffer, Meike
|b 5
700 1 _ |a Haass, Christian
|0 P:(DE-2719)2202037
|b 6
|u dzne
700 1 _ |a Hemmer, Bernhard
|0 0000-0001-5985-6784
|b 7
700 1 _ |a Maier, Mathias
|b 8
700 1 _ |a Korn, Thomas
|b 9
700 1 _ |a Knier, Benjamin
|0 0000-0003-4187-9472
|b 10
|e Corresponding author
773 _ _ |a 10.1177/13524585211028831
|g p. 135245852110288 -
|0 PERI:(DE-600)2008225-3
|n 4
|p 522-531
|t Multiple sclerosis journal
|v 28
|y 2022
|x 1477-0970
856 4 _ |u https://journals.sagepub.com/doi/10.1177/13524585211028831?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
856 4 _ |u https://pub.dzne.de/record/155448/files/19537.pdf
|y OpenAccess
909 C O |o oai:pub.dzne.de:155448
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 6
|6 P:(DE-2719)2202037
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-352
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Disease Mechanisms
|x 0
913 0 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-342
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Disease Mechanisms and Model Systems
|x 0
914 1 _ |y 2022
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2022-11-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2022-11-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2022-11-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2021-01-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2022-11-16
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b MULT SCLER J : 2021
|d 2022-11-16
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-01-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2022-11-16
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2022-11-16
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2022-11-16
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b MULT SCLER J : 2021
|d 2022-11-16
915 _ _ |a National-Konsortium
|0 StatID:(DE-HGF)0430
|2 StatID
|d 2022-11-16
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-01-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1110
|2 StatID
|b Current Contents - Clinical Medicine
|d 2022-11-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2022-11-16
920 1 _ |0 I:(DE-2719)1110007
|k AG Haass
|l Molecular Neurodegeneration
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1110007
980 _ _ |a UNRESTRICTED
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21