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@ARTICLE{BerdugoVega:155467,
      author       = {Berdugo-Vega, Gabriel and Lee, Chi-Chieh and Garthe,
                      Alexander and Kempermann, Gerd and Calegari, Federico},
      title        = {{A}dult-born neurons promote cognitive flexibility by
                      improving memory precision and indexing.},
      journal      = {Hippocampus},
      volume       = {31},
      number       = {10},
      issn         = {1098-1063},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-00666},
      pages        = {1068-1079},
      year         = {2021},
      abstract     = {Adult neurogenesis in the hippocampal dentate gyrus (DG) is
                      an extraordinary form of plasticity fundamental for
                      cognitive flexibility. Recent evidence showed that newborn
                      neurons differentially modulate input to the infra- and
                      supra-pyramidal blades of the DG during the processing of
                      spatial and contextual information, respectively. However,
                      how this differential regulation by neurogenesis is
                      translated into different aspects contributing cognitive
                      flexibility is unclear. Here, we increased adult-born
                      neurons by a genetic expansion of neural stem cells and
                      studied their influence during navigational learning. We
                      found that increased neurogenesis improved both memory
                      precision and flexibility. Interestingly, each of these
                      gains was associated with distinct subregional patterns of
                      activity and better separation of memory representations in
                      the DG-CA3 network. Our results highlight the role of
                      adult-born neurons in promoting memory precision and
                      indexing and suggests their anatomical allocation within
                      specific DG-CA3 compartments, together contributing to
                      cognitive flexibility.},
      keywords     = {Cognition: physiology / Dentate Gyrus: physiology / Neural
                      Stem Cells / Neurogenesis: physiology / Neurons: physiology
                      / cognitive flexibility (Other) / hippocampal neurogenesis
                      (Other) / indexing (Other) / memory precision (Other)},
      cin          = {AG Garthe / AG Kempermann},
      ddc          = {610},
      cid          = {I:(DE-2719)1740001 / I:(DE-2719)1710001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34174010},
      doi          = {10.1002/hipo.23373},
      url          = {https://pub.dzne.de/record/155467},
}