Home > Publications Database > Adult-born neurons promote cognitive flexibility by improving memory precision and indexing. > print

001     155467
005     20240425115930.0
024 7 _ |a 10.1002/hipo.23373
|2 doi
024 7 _ |a pmid:34174010
|2 pmid
024 7 _ |a 1050-9631
|2 ISSN
024 7 _ |a 1098-1063
|2 ISSN
024 7 _ |a altmetric:108252176
|2 altmetric
037 _ _ |a DZNE-2021-00666
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Berdugo-Vega, Gabriel
|b 0
245 _ _ |a Adult-born neurons promote cognitive flexibility by improving memory precision and indexing.
260 _ _ |a New York, NY [u.a.]
|c 2021
|b Wiley
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1713966522_26796
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Adult neurogenesis in the hippocampal dentate gyrus (DG) is an extraordinary form of plasticity fundamental for cognitive flexibility. Recent evidence showed that newborn neurons differentially modulate input to the infra- and supra-pyramidal blades of the DG during the processing of spatial and contextual information, respectively. However, how this differential regulation by neurogenesis is translated into different aspects contributing cognitive flexibility is unclear. Here, we increased adult-born neurons by a genetic expansion of neural stem cells and studied their influence during navigational learning. We found that increased neurogenesis improved both memory precision and flexibility. Interestingly, each of these gains was associated with distinct subregional patterns of activity and better separation of memory representations in the DG-CA3 network. Our results highlight the role of adult-born neurons in promoting memory precision and indexing and suggests their anatomical allocation within specific DG-CA3 compartments, together contributing to cognitive flexibility.
536 _ _ |a 352 - Disease Mechanisms (POF4-352)
|0 G:(DE-HGF)POF4-352
|c POF4-352
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a cognitive flexibility
|2 Other
650 _ 7 |a hippocampal neurogenesis
|2 Other
650 _ 7 |a indexing
|2 Other
650 _ 7 |a memory precision
|2 Other
650 _ 2 |a Cognition: physiology
|2 MeSH
650 _ 2 |a Dentate Gyrus: physiology
|2 MeSH
650 _ 2 |a Neural Stem Cells
|2 MeSH
650 _ 2 |a Neurogenesis: physiology
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
700 1 _ |a Lee, Chi-Chieh
|b 1
700 1 _ |a Garthe, Alexander
|0 P:(DE-2719)2810535
|b 2
|u dzne
700 1 _ |a Kempermann, Gerd
|0 P:(DE-2719)2000011
|b 3
|u dzne
700 1 _ |a Calegari, Federico
|0 0000-0002-3703-2802
|b 4
|e Corresponding author
773 _ _ |a 10.1002/hipo.23373
|g p. hipo.23373
|0 PERI:(DE-600)1498049-6
|n 10
|p 1068-1079
|t Hippocampus
|v 31
|y 2021
|x 1098-1063
856 4 _ |u https://onlinelibrary.wiley.com/doi/10.1002/hipo.23373
856 4 _ |u https://pub.dzne.de/record/155467/files/DZNE-2021-00666.pdf
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/155467/files/DZNE-2021-00666.pdf?subformat=pdfa
|x pdfa
|y OpenAccess
909 C O |o oai:pub.dzne.de:155467
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 2
|6 P:(DE-2719)2810535
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 3
|6 P:(DE-2719)2000011
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-352
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Disease Mechanisms
|x 0
913 0 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-342
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Disease Mechanisms and Model Systems
|x 0
914 1 _ |y 2021
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2022-11-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2022-11-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2022-11-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2022-11-22
915 _ _ |a Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
|0 LIC:(DE-HGF)CCBYNCND4
|2 HGFVOC
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b HIPPOCAMPUS : 2021
|d 2022-11-22
915 _ _ |a DEAL Wiley
|0 StatID:(DE-HGF)3001
|2 StatID
|d 2021-01-29
|w ger
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2022-11-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2022-11-22
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
|d 2022-11-22
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2022-11-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-01-29
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2022-11-22
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2022-11-22
920 1 _ |0 I:(DE-2719)1740001
|k AG Garthe
|l Technology Platform Neurobiology of Behaviour
|x 0
920 1 _ |0 I:(DE-2719)1710001
|k AG Kempermann
|l Adult Neurogenesis
|x 1
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1740001
980 _ _ |a I:(DE-2719)1710001
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21