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000155514 041__ $$aEnglish
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000155514 1001_ $$0P:(DE-2719)9000770$$aSoch, Joram$$b0$$eFirst author$$udzne
000155514 245__ $$aA comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging.
000155514 260__ $$aNew York, NY$$bWiley-Liss$$c2021
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000155514 520__ $$aOlder adults and particularly those at risk for developing dementia typically show a decline in episodic memory performance, which has been associated with altered memory network activity detectable via functional magnetic resonance imaging (fMRI). To quantify the degree of these alterations, a score has been developed as a putative imaging biomarker for successful aging in memory for older adults (Functional Activity Deviations during Encoding, FADE; Düzel et al., Hippocampus, 2011; 21: 803-814). Here, we introduce and validate a more comprehensive version of the FADE score, termed FADE-SAME (Similarity of Activations during Memory Encoding), which differs from the original FADE score by considering not only activations but also deactivations in fMRI contrasts of stimulus novelty and successful encoding, and by taking into account the variance of young adults' activations. We computed both scores for novelty and subsequent memory contrasts in a cohort of 217 healthy adults, including 106 young and 111 older participants, as well as a replication cohort of 117 young subjects. We further tested the stability and generalizability of both scores by controlling for different MR scanners and gender, as well as by using different data sets of young adults as reference samples. Both scores showed robust age-group-related differences for the subsequent memory contrast, and the FADE-SAME score additionally exhibited age-group-related differences for the novelty contrast. Furthermore, both scores correlate with behavioral measures of cognitive aging, namely memory performance. Taken together, our results suggest that single-value scores of memory-related fMRI responses may constitute promising biomarkers for quantifying neurocognitive aging.
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000155514 650_7 $$2Other$$acognitive aging
000155514 650_7 $$2Other$$aepisodic memory
000155514 650_7 $$2Other$$afMRI
000155514 650_7 $$2Other$$ahippocampus
000155514 650_7 $$2Other$$amemory impairment
000155514 650_7 $$2Other$$asubsequent memory effect
000155514 650_2 $$2MeSH$$aAdolescent
000155514 650_2 $$2MeSH$$aAdult
000155514 650_2 $$2MeSH$$aAge Factors
000155514 650_2 $$2MeSH$$aAged
000155514 650_2 $$2MeSH$$aAged, 80 and over
000155514 650_2 $$2MeSH$$aBrain: diagnostic imaging
000155514 650_2 $$2MeSH$$aBrain: physiology
000155514 650_2 $$2MeSH$$aCognitive Aging: physiology
000155514 650_2 $$2MeSH$$aFemale
000155514 650_2 $$2MeSH$$aFunctional Neuroimaging: methods
000155514 650_2 $$2MeSH$$aHippocampus: diagnostic imaging
000155514 650_2 $$2MeSH$$aHippocampus: physiology
000155514 650_2 $$2MeSH$$aHumans
000155514 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000155514 650_2 $$2MeSH$$aMale
000155514 650_2 $$2MeSH$$aMemory, Episodic
000155514 650_2 $$2MeSH$$aMiddle Aged
000155514 650_2 $$2MeSH$$aYoung Adult
000155514 7001_ $$00000-0001-9681-6298$$aRichter, Anni$$b1
000155514 7001_ $$0P:(DE-2719)9001467$$aSchütze, Hartmut$$b2$$udzne
000155514 7001_ $$0P:(DE-2719)9000615$$aKizilirmak, Jasmin$$b3$$udzne
000155514 7001_ $$0P:(DE-2719)2812914$$aAssmann, Anne$$b4$$udzne
000155514 7001_ $$aBehnisch, Gusalija$$b5
000155514 7001_ $$aFeldhoff, Hannah$$b6
000155514 7001_ $$aFischer, Larissa$$b7
000155514 7001_ $$aHeil, Julius$$b8
000155514 7001_ $$aKnopf, Lea$$b9
000155514 7001_ $$00000-0002-8730-5653$$aMerkel, Christian$$b10
000155514 7001_ $$aRaschick, Matthias$$b11
000155514 7001_ $$aSchietke, Clara-Johanna$$b12
000155514 7001_ $$aSchult, Annika$$b13
000155514 7001_ $$aSeidenbecher, Constanze I$$b14
000155514 7001_ $$0P:(DE-2719)2812398$$aYakupov, Renat$$b15$$udzne
000155514 7001_ $$0P:(DE-2719)2814076$$aZiegler, Gabriel$$b16$$udzne
000155514 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b17$$udzne
000155514 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b18$$udzne
000155514 7001_ $$0P:(DE-2719)2814326$$aSchott, Björn$$b19$$eLast author$$udzne
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