TY  - JOUR
AU  - Soch, Joram
AU  - Richter, Anni
AU  - Schütze, Hartmut
AU  - Kizilirmak, Jasmin
AU  - Assmann, Anne
AU  - Behnisch, Gusalija
AU  - Feldhoff, Hannah
AU  - Fischer, Larissa
AU  - Heil, Julius
AU  - Knopf, Lea
AU  - Merkel, Christian
AU  - Raschick, Matthias
AU  - Schietke, Clara-Johanna
AU  - Schult, Annika
AU  - Seidenbecher, Constanze I
AU  - Yakupov, Renat
AU  - Ziegler, Gabriel
AU  - Wiltfang, Jens
AU  - Düzel, Emrah
AU  - Schott, Björn
TI  - A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging.
JO  - Human brain mapping
VL  - 42
IS  - 14
SN  - 1097-0193
CY  - New York, NY
PB  - Wiley-Liss
M1  - DZNE-2021-00710
SP  - 4478-4496
PY  - 2021
AB  - Older adults and particularly those at risk for developing dementia typically show a decline in episodic memory performance, which has been associated with altered memory network activity detectable via functional magnetic resonance imaging (fMRI). To quantify the degree of these alterations, a score has been developed as a putative imaging biomarker for successful aging in memory for older adults (Functional Activity Deviations during Encoding, FADE; Düzel et al., Hippocampus, 2011; 21: 803-814). Here, we introduce and validate a more comprehensive version of the FADE score, termed FADE-SAME (Similarity of Activations during Memory Encoding), which differs from the original FADE score by considering not only activations but also deactivations in fMRI contrasts of stimulus novelty and successful encoding, and by taking into account the variance of young adults' activations. We computed both scores for novelty and subsequent memory contrasts in a cohort of 217 healthy adults, including 106 young and 111 older participants, as well as a replication cohort of 117 young subjects. We further tested the stability and generalizability of both scores by controlling for different MR scanners and gender, as well as by using different data sets of young adults as reference samples. Both scores showed robust age-group-related differences for the subsequent memory contrast, and the FADE-SAME score additionally exhibited age-group-related differences for the novelty contrast. Furthermore, both scores correlate with behavioral measures of cognitive aging, namely memory performance. Taken together, our results suggest that single-value scores of memory-related fMRI responses may constitute promising biomarkers for quantifying neurocognitive aging.
KW  - Adolescent
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and over
KW  - Brain: diagnostic imaging
KW  - Brain: physiology
KW  - Cognitive Aging: physiology
KW  - Female
KW  - Functional Neuroimaging: methods
KW  - Hippocampus: diagnostic imaging
KW  - Hippocampus: physiology
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Memory, Episodic
KW  - Middle Aged
KW  - Young Adult
KW  - cognitive aging (Other)
KW  - episodic memory (Other)
KW  - fMRI (Other)
KW  - hippocampus (Other)
KW  - memory impairment (Other)
KW  - subsequent memory effect (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC8410542
C6  - pmid:34132437
DO  - DOI:10.1002/hbm.25559
UR  - https://pub.dzne.de/record/155514
ER  -