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@ARTICLE{Soch:155514,
      author       = {Soch, Joram and Richter, Anni and Schütze, Hartmut and
                      Kizilirmak, Jasmin and Assmann, Anne and Behnisch, Gusalija
                      and Feldhoff, Hannah and Fischer, Larissa and Heil, Julius
                      and Knopf, Lea and Merkel, Christian and Raschick, Matthias
                      and Schietke, Clara-Johanna and Schult, Annika and
                      Seidenbecher, Constanze I and Yakupov, Renat and Ziegler,
                      Gabriel and Wiltfang, Jens and Düzel, Emrah and Schott,
                      Björn},
      title        = {{A} comprehensive score reflecting memory-related f{MRI}
                      activations and deactivations as potential biomarker for
                      neurocognitive aging.},
      journal      = {Human brain mapping},
      volume       = {42},
      number       = {14},
      issn         = {1097-0193},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DZNE-2021-00710},
      pages        = {4478-4496},
      year         = {2021},
      abstract     = {Older adults and particularly those at risk for developing
                      dementia typically show a decline in episodic memory
                      performance, which has been associated with altered memory
                      network activity detectable via functional magnetic
                      resonance imaging (fMRI). To quantify the degree of these
                      alterations, a score has been developed as a putative
                      imaging biomarker for successful aging in memory for older
                      adults (Functional Activity Deviations during Encoding,
                      FADE; Düzel et al., Hippocampus, 2011; 21: 803-814). Here,
                      we introduce and validate a more comprehensive version of
                      the FADE score, termed FADE-SAME (Similarity of Activations
                      during Memory Encoding), which differs from the original
                      FADE score by considering not only activations but also
                      deactivations in fMRI contrasts of stimulus novelty and
                      successful encoding, and by taking into account the variance
                      of young adults' activations. We computed both scores for
                      novelty and subsequent memory contrasts in a cohort of 217
                      healthy adults, including 106 young and 111 older
                      participants, as well as a replication cohort of 117 young
                      subjects. We further tested the stability and
                      generalizability of both scores by controlling for different
                      MR scanners and gender, as well as by using different data
                      sets of young adults as reference samples. Both scores
                      showed robust age-group-related differences for the
                      subsequent memory contrast, and the FADE-SAME score
                      additionally exhibited age-group-related differences for the
                      novelty contrast. Furthermore, both scores correlate with
                      behavioral measures of cognitive aging, namely memory
                      performance. Taken together, our results suggest that
                      single-value scores of memory-related fMRI responses may
                      constitute promising biomarkers for quantifying
                      neurocognitive aging.},
      keywords     = {Adolescent / Adult / Age Factors / Aged / Aged, 80 and over
                      / Brain: diagnostic imaging / Brain: physiology / Cognitive
                      Aging: physiology / Female / Functional Neuroimaging:
                      methods / Hippocampus: diagnostic imaging / Hippocampus:
                      physiology / Humans / Magnetic Resonance Imaging / Male /
                      Memory, Episodic / Middle Aged / Young Adult / cognitive
                      aging (Other) / episodic memory (Other) / fMRI (Other) /
                      hippocampus (Other) / memory impairment (Other) / subsequent
                      memory effect (Other)},
      cin          = {AG Düzel / AG Wiltfang},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1410006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8410542},
      pubmed       = {pmid:34132437},
      doi          = {10.1002/hbm.25559},
      url          = {https://pub.dzne.de/record/155514},
}