TY  - JOUR
AU  - Lo, Eng H
AU  - Albers, Gregory W
AU  - Dichgans, Martin
AU  - Donnan, Geoffrey
AU  - Esposito, Elga
AU  - Foster, Russell
AU  - Howells, David W
AU  - Huang, Yi-Ge
AU  - Ji, Xunming
AU  - Klerman, Elizabeth B
AU  - Lee, Sarah
AU  - Li, Wenlu
AU  - Liebeskind, David S
AU  - Lizasoain, Ignacio
AU  - Mandeville, Emiri T
AU  - Moro, Maria A
AU  - Ning, MingMing
AU  - Ray, David
AU  - Sakadžić, Sava
AU  - Saver, Jeffrey L
AU  - Scheer, Frank A J L
AU  - Selim, Magdy
AU  - Tiedt, Steffen
AU  - Zhang, Fang
AU  - Buchan, Alastair M
TI  - Circadian Biology and Stroke.
JO  - Stroke
VL  - 52
IS  - 6
SN  - 1524-4628
CY  - Philadelphia, Pa.
PB  - Lippincott Williams & Wilkins
M1  - DZNE-2021-00734
SP  - 2180 - 2190
PY  - 2021
AB  - Circadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest that circadian biology may significantly affect the mechanisms of susceptibility, injury, recovery, and the response to therapy in stroke. In this review/perspective, we survey the accumulating literature and attempt to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke. Accounting for the complex and multifactorial effects of circadian rhythm may improve translational opportunities for stroke diagnostics and therapeutics.
KW  - Animals
KW  - Circadian Rhythm: physiology
KW  - Clinical Trials as Topic: methods
KW  - Humans
KW  - Inflammation Mediators: physiology
KW  - Neurovascular Coupling: physiology
KW  - Stroke: diagnosis
KW  - Stroke: physiopathology
KW  - Stroke: therapy
KW  - biomarkers (Other)
KW  - circadian rhythm (Other)
KW  - immune system (Other)
KW  - ischemia (Other)
KW  - neuroprotection (Other)
KW  - sleep (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33940951
DO  - DOI:10.1161/STROKEAHA.120.031742
UR  - https://pub.dzne.de/record/155556
ER  -