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000155560 1001_ $$aSong, Mengmeng$$b0
000155560 245__ $$aBinding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET.
000155560 260__ $$aLondon$$bSage$$c2021
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000155560 520__ $$aThe novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.
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000155560 650_7 $$2Other$$aPI-2620
000155560 650_7 $$2Other$$aTau
000155560 650_7 $$2Other$$aaffinity
000155560 650_7 $$2Other$$abinding
000155560 650_7 $$2Other$$akinetic modelling
000155560 650_2 $$2MeSH$$aFluorine Radioisotopes
000155560 650_2 $$2MeSH$$aHumans
000155560 650_2 $$2MeSH$$aImage Interpretation, Computer-Assisted: methods
000155560 650_2 $$2MeSH$$aNeuroimaging: methods
000155560 650_2 $$2MeSH$$aPositron-Emission Tomography: methods
000155560 650_2 $$2MeSH$$aProtein Isoforms: analysis
000155560 650_2 $$2MeSH$$aRadiopharmaceuticals
000155560 650_2 $$2MeSH$$aTauopathies: diagnostic imaging
000155560 650_2 $$2MeSH$$atau Proteins: analysis
000155560 7001_ $$aBeyer, Leonie$$b1
000155560 7001_ $$aKaiser, Lena$$b2
000155560 7001_ $$aBarthel, Henryk$$b3
000155560 7001_ $$0P:(DE-2719)2812285$$aEimeren, Thilo$$b4$$udzne
000155560 7001_ $$0P:(DE-2719)9000201$$aMarek, Kenneth$$b5$$udzne
000155560 7001_ $$aNitschmann, Alexander$$b6
000155560 7001_ $$0P:(DE-2719)9001444$$aScheifele, Heinrich Maximilian$$b7$$udzne
000155560 7001_ $$0P:(DE-2719)9000852$$aPalleis, Carla$$b8$$udzne
000155560 7001_ $$0P:(DE-2719)2811600$$aRespondek, Gesine$$b9$$udzne
000155560 7001_ $$aKern, Maike$$b10
000155560 7001_ $$aBiechele, Gloria$$b11
000155560 7001_ $$aHammes, Jochen$$b12
000155560 7001_ $$aBischof, Gèrard$$b13
000155560 7001_ $$aBarbe, Michael$$b14
000155560 7001_ $$aOnur, Özgür$$b15
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000155560 7001_ $$aSaur, Dorothee$$b17
000155560 7001_ $$aSchroeter, Matthias L$$b18
000155560 7001_ $$aRumpf, Jost-Julian$$b19
000155560 7001_ $$aRullmann, Michael$$b20
000155560 7001_ $$aSchildan, Andreas$$b21
000155560 7001_ $$aPatt, Marianne$$b22
000155560 7001_ $$aNeumaier, Bernd$$b23
000155560 7001_ $$00000-0003-4247-184X$$aBarret, Olivier$$b24
000155560 7001_ $$aMadonia, Jennifer$$b25
000155560 7001_ $$00000-0002-9105-2943$$aRussell, David S$$b26
000155560 7001_ $$aStephens, Andrew W$$b27
000155560 7001_ $$aMueller, Andre$$b28
000155560 7001_ $$aRoeber, Sigrun$$b29
000155560 7001_ $$0P:(DE-2719)2810441$$aHerms, Jochen$$b30$$udzne
000155560 7001_ $$aBötzel, Kai$$b31
000155560 7001_ $$0P:(DE-2719)2810712$$aDanek, Adrian$$b32$$udzne
000155560 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b33$$udzne
000155560 7001_ $$aClassen, Joseph$$b34
000155560 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter U$$b35$$udzne
000155560 7001_ $$aBartenstein, Peter$$b36
000155560 7001_ $$aVillemagne, Victor$$b37
000155560 7001_ $$0P:(DE-2719)2811239$$aDrzezga, Alexander$$b38$$udzne
000155560 7001_ $$aSeibyl, John$$b39
000155560 7001_ $$0P:(DE-2719)2814810$$aSabri, Osama$$b40$$udzne
000155560 7001_ $$aBoening, Guido$$b41
000155560 7001_ $$aZiegler, Sibylle$$b42
000155560 7001_ $$00000-0002-9247-2843$$aBrendel, Matthias$$b43
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