TY  - JOUR
AU  - Song, Mengmeng
AU  - Beyer, Leonie
AU  - Kaiser, Lena
AU  - Barthel, Henryk
AU  - Eimeren, Thilo
AU  - Marek, Kenneth
AU  - Nitschmann, Alexander
AU  - Scheifele, Heinrich Maximilian
AU  - Palleis, Carla
AU  - Respondek, Gesine
AU  - Kern, Maike
AU  - Biechele, Gloria
AU  - Hammes, Jochen
AU  - Bischof, Gèrard
AU  - Barbe, Michael
AU  - Onur, Özgür
AU  - Jessen, Frank
AU  - Saur, Dorothee
AU  - Schroeter, Matthias L
AU  - Rumpf, Jost-Julian
AU  - Rullmann, Michael
AU  - Schildan, Andreas
AU  - Patt, Marianne
AU  - Neumaier, Bernd
AU  - Barret, Olivier
AU  - Madonia, Jennifer
AU  - Russell, David S
AU  - Stephens, Andrew W
AU  - Mueller, Andre
AU  - Roeber, Sigrun
AU  - Herms, Jochen
AU  - Bötzel, Kai
AU  - Danek, Adrian
AU  - Levin, Johannes
AU  - Classen, Joseph
AU  - Höglinger, Günter U
AU  - Bartenstein, Peter
AU  - Villemagne, Victor
AU  - Drzezga, Alexander
AU  - Seibyl, John
AU  - Sabri, Osama
AU  - Boening, Guido
AU  - Ziegler, Sibylle
AU  - Brendel, Matthias
TI  - Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET.
JO  - Journal of cerebral blood flow & metabolism
VL  - 41
IS  - 11
SN  - 1559-7016
CY  - London
PB  - Sage
M1  - DZNE-2021-00738
SP  - 2957-2972
PY  - 2021
AB  - The novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 </td><td width="150">
AB  -  k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.
KW  - Fluorine Radioisotopes
KW  - Humans
KW  - Image Interpretation, Computer-Assisted: methods
KW  - Neuroimaging: methods
KW  - Positron-Emission Tomography: methods
KW  - Protein Isoforms: analysis
KW  - Radiopharmaceuticals
KW  - Tauopathies: diagnostic imaging
KW  - tau Proteins: analysis
KW  - PI-2620 (Other)
KW  - Tau (Other)
KW  - affinity (Other)
KW  - binding (Other)
KW  - kinetic modelling (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC8545042
C6  - pmid:34044665
DO  - DOI:10.1177/0271678X211018904
UR  - https://pub.dzne.de/record/155560
ER  -