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@ARTICLE{Song:155560,
      author       = {Song, Mengmeng and Beyer, Leonie and Kaiser, Lena and
                      Barthel, Henryk and Eimeren, Thilo and Marek, Kenneth and
                      Nitschmann, Alexander and Scheifele, Heinrich Maximilian and
                      Palleis, Carla and Respondek, Gesine and Kern, Maike and
                      Biechele, Gloria and Hammes, Jochen and Bischof, Gèrard and
                      Barbe, Michael and Onur, Özgür and Jessen, Frank and Saur,
                      Dorothee and Schroeter, Matthias L and Rumpf, Jost-Julian
                      and Rullmann, Michael and Schildan, Andreas and Patt,
                      Marianne and Neumaier, Bernd and Barret, Olivier and
                      Madonia, Jennifer and Russell, David S and Stephens, Andrew
                      W and Mueller, Andre and Roeber, Sigrun and Herms, Jochen
                      and Bötzel, Kai and Danek, Adrian and Levin, Johannes and
                      Classen, Joseph and Höglinger, Günter U and Bartenstein,
                      Peter and Villemagne, Victor and Drzezga, Alexander and
                      Seibyl, John and Sabri, Osama and Boening, Guido and
                      Ziegler, Sibylle and Brendel, Matthias},
      title        = {{B}inding characteristics of [18{F}]{PI}-2620 distinguish
                      the clinically predicted tau isoform in different
                      tauopathies by {PET}.},
      journal      = {Journal of cerebral blood flow $\&$ metabolism},
      volume       = {41},
      number       = {11},
      issn         = {1559-7016},
      address      = {London},
      publisher    = {Sage},
      reportid     = {DZNE-2021-00738},
      pages        = {2957-2972},
      year         = {2021},
      abstract     = {The novel tau-PET tracer [18F]PI-2620 detects the
                      3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the
                      4R-tauopathies corticobasal syndrome (CBS) and progressive
                      supranuclear palsy (PSP). We determined whether [18F]PI-2620
                      binding characteristics deriving from non-invasive reference
                      tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten
                      patients with a 3/4R tauopathy (AD continuum) and 29
                      patients with a 4R tauopathy (CBS, PSP) were evaluated.
                      [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the
                      distribution volume ratio (DVR) was calculated.
                      [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11
                      healthy controls) were evaluated by non-invasive kinetic
                      modelling. R1 (delivery), k2 $\&$ k2a (efflux), DVR, 30-60
                      min standardized-uptake-value-ratios (SUVR30-60) and the
                      linear slope of post-perfusion phase SUVR (9-60 min p.i.)
                      were compared between 3/4R- and 4R-tauopathies. Cortical
                      clusters of 4R-tau cases indicated higher delivery (R1SRTM:
                      0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux
                      (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p <
                      0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001),
                      lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and
                      flatter slopes of the post-perfusion phase (slope9-60:
                      0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p <
                      0.0001) when compared to 3/4R-tau cases. [18F]PI-2620
                      binding characteristics in cortical regions differentiate
                      3/4R- and 4R-tauopathies. Higher tracer clearance indicates
                      less stable binding in 4R tauopathies when compared to
                      3/4R-tauopathies.},
      keywords     = {Fluorine Radioisotopes / Humans / Image Interpretation,
                      Computer-Assisted: methods / Neuroimaging: methods /
                      Positron-Emission Tomography: methods / Protein Isoforms:
                      analysis / Radiopharmaceuticals / Tauopathies: diagnostic
                      imaging / tau Proteins: analysis / PI-2620 (Other) / Tau
                      (Other) / affinity (Other) / binding (Other) / kinetic
                      modelling (Other)},
      cin          = {Clinical Dementia Research München / AG Jessen / AG
                      Höglinger 2 / AG Boecker},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016 / I:(DE-2719)1011102 /
                      I:(DE-2719)1111015 / I:(DE-2719)1011202},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8545042},
      pubmed       = {pmid:34044665},
      doi          = {10.1177/0271678X211018904},
      url          = {https://pub.dzne.de/record/155560},
}