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@ARTICLE{Pr:155568,
      author       = {Prüß, Harald},
      title        = {{A}utoantibodies in neurological disease.},
      journal      = {Nature reviews / Immunology},
      volume       = {21},
      number       = {12},
      issn         = {1474-1741},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {DZNE-2021-00746},
      pages        = {798-813},
      year         = {2021},
      abstract     = {The realization that autoantibodies can contribute to
                      dysfunction of the brain has brought about a paradigm shift
                      in neurological diseases over the past decade, offering up
                      important novel diagnostic and therapeutic opportunities.
                      Detection of specific autoantibodies to neuronal or glial
                      targets has resulted in a better understanding of central
                      nervous system autoimmunity and in the reclassification of
                      some diseases previously thought to result from infectious,
                      'idiopathic' or psychogenic causes. The most prominent
                      examples, such as aquaporin 4 autoantibodies in
                      neuromyelitis optica or NMDAR autoantibodies in
                      encephalitis, have stimulated an entire field of clinical
                      and experimental studies on disease mechanisms and
                      immunological abnormalities. Also, these findings inspired
                      the search for additional autoantibodies, which has been
                      very successful to date and has not yet reached its peak.
                      This Review summarizes this rapid development at a point in
                      time where preclinical studies have started delivering
                      fundamental new data for mechanistic understanding, where
                      new technologies are being introduced into this field, and -
                      most importantly - where the first specifically tailored
                      immunotherapeutic approaches are emerging.},
      keywords     = {Animals / Aquaporin 4: immunology / Autoantibodies:
                      immunology / Autoimmunity / Brain: immunology / Brain:
                      physiopathology / Encephalitis: immunology / Encephalitis:
                      physiopathology / Encephalitis: therapy / Humans /
                      Neuromyelitis Optica: immunology / Neuromyelitis Optica:
                      physiopathology / Neuromyelitis Optica: therapy / Receptors,
                      N-Methyl-D-Aspartate: immunology},
      cin          = {AG Prüß},
      ddc          = {570},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33976421},
      pmc          = {pmc:PMC8111372},
      doi          = {10.1038/s41577-021-00543-w},
      url          = {https://pub.dzne.de/record/155568},
}