%0 Journal Article
%A Schmidt, Nele
%A Tödt, Inken
%A Berg, Daniela
%A Schlenstedt, Christian
%A Folkerts, Ann-Kristin
%A Ophey, Anja
%A Dimenshteyn, Karina
%A Elben, Saskia
%A Wojtecki, Lars
%A Liepelt-Scarfone, Inga
%A Schulte, Claudia
%A Sulzer, Patricia
%A Eggers, Carsten
%A Kalbe, Elke
%A Witt, Karsten
%T Memory enhancement by multidomain group cognitive training in patients with Parkinson's disease and mild cognitive impairment: long-term effects of a multicenter randomized controlled trial.
%J Journal of neurology
%V 268
%N 12
%@ 0340-5354
%C Berlin
%I Springer
%M DZNE-2021-00752
%P 4655-4666
%D 2021
%Z ISSN 1432-1459 not unique: **2 hits**.
%X Meta-analyses indicate positive effects of cognitive training (CT) in patients with Parkinson's disease (PD), however, most previous studies had small sample sizes and did not evaluate long-term follow-up. Therefore, a multicenter randomized controlled, single-blinded trial (Train-ParC study) was conducted to examine CT effects in PD patients with mild cognitive impairment (PD-MCI). Immediately after CT, an enhancement of executive functions was demonstrated. Here, we present the long-term results 6 and 12 months after CT.At baseline, 64 PD-MCI patients were randomized to a multidomain CT group (n = 33) or to a low-intensity physical activity training control group (PT) (n = 31). Both interventions included 90 min training sessions twice a week for 6 weeks. 54 patients completed the 6 months (CT: n = 28, PT: n = 26) and 49 patients the 12 months follow-up assessment (CT: n = 25, PT: n = 24). Primary study outcomes were memory and executive functioning composite scores. Mixed repeated measures ANOVAs, post-hoc t tests and multiple regression analyses were conducted.We found a significant time x group interaction effect for the memory composite score (p = 0.006, η2 = 0.214), but not for the executive composite score (p = 0.967, η2 = 0.002). Post-hoc t tests revealed significant verbal and nonverbal memory improvements from pre-intervention to 6 months, but not to 12 months follow-up assessment in the CT group. No significant predictors were found for predicting memory improvement after CT.This study provides Class 1 evidence that multidomain CT enhances memory functioning in PD-MCI after 6 months but not after 12 months, whereas executive functioning did not change in the long-term.German Clinical Trials Register (ID: DRKS00010186), 21.3.2016 (The study registration is outlined as retrospective due to an administrative delay. The first patient was enrolled three months after the registration process was started. A formal confirmation of this process from the German Clinical Trials Register can be obtained from the authors.).
%K Cognition
%K Cognition Disorders
%K Cognitive Dysfunction: etiology
%K Cognitive Dysfunction: therapy
%K Humans
%K Neuropsychological Tests
%K Parkinson Disease: complications
%K Parkinson Disease: therapy
%K Retrospective Studies
%K Cognition (Other)
%K Cognitive training (Other)
%K Long-term effects (Other)
%K Mild cognitive impairment (Other)
%K Non-pharmacological intervention (Other)
%K Parkinson’s disease (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC8563628
%$ pmid:33904966
%R 10.1007/s00415-021-10568-9
%U https://pub.dzne.de/record/155574