TY  - JOUR
AU  - Schmidt, Nele
AU  - Tödt, Inken
AU  - Berg, Daniela
AU  - Schlenstedt, Christian
AU  - Folkerts, Ann-Kristin
AU  - Ophey, Anja
AU  - Dimenshteyn, Karina
AU  - Elben, Saskia
AU  - Wojtecki, Lars
AU  - Liepelt-Scarfone, Inga
AU  - Schulte, Claudia
AU  - Sulzer, Patricia
AU  - Eggers, Carsten
AU  - Kalbe, Elke
AU  - Witt, Karsten
TI  - Memory enhancement by multidomain group cognitive training in patients with Parkinson's disease and mild cognitive impairment: long-term effects of a multicenter randomized controlled trial.
JO  - Journal of neurology
VL  - 268
IS  - 12
SN  - 0340-5354
CY  - Berlin
PB  - Springer
M1  - DZNE-2021-00752
SP  - 4655-4666
PY  - 2021
N1  - ISSN 1432-1459 not unique: **2 hits**.
AB  - Meta-analyses indicate positive effects of cognitive training (CT) in patients with Parkinson's disease (PD), however, most previous studies had small sample sizes and did not evaluate long-term follow-up. Therefore, a multicenter randomized controlled, single-blinded trial (Train-ParC study) was conducted to examine CT effects in PD patients with mild cognitive impairment (PD-MCI). Immediately after CT, an enhancement of executive functions was demonstrated. Here, we present the long-term results 6 and 12 months after CT.At baseline, 64 PD-MCI patients were randomized to a multidomain CT group (n = 33) or to a low-intensity physical activity training control group (PT) (n = 31). Both interventions included 90 min training sessions twice a week for 6 weeks. 54 patients completed the 6 months (CT: n = 28, PT: n = 26) and 49 patients the 12 months follow-up assessment (CT: n = 25, PT: n = 24). Primary study outcomes were memory and executive functioning composite scores. Mixed repeated measures ANOVAs, post-hoc t tests and multiple regression analyses were conducted.We found a significant time x group interaction effect for the memory composite score (p = 0.006, η2 = 0.214), but not for the executive composite score (p = 0.967, η2 = 0.002). Post-hoc t tests revealed significant verbal and nonverbal memory improvements from pre-intervention to 6 months, but not to 12 months follow-up assessment in the CT group. No significant predictors were found for predicting memory improvement after CT.This study provides Class 1 evidence that multidomain CT enhances memory functioning in PD-MCI after 6 months but not after 12 months, whereas executive functioning did not change in the long-term.German Clinical Trials Register (ID: DRKS00010186), 21.3.2016 (The study registration is outlined as retrospective due to an administrative delay. The first patient was enrolled three months after the registration process was started. A formal confirmation of this process from the German Clinical Trials Register can be obtained from the authors.).
KW  - Cognition
KW  - Cognition Disorders
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: therapy
KW  - Humans
KW  - Neuropsychological Tests
KW  - Parkinson Disease: complications
KW  - Parkinson Disease: therapy
KW  - Retrospective Studies
KW  - Cognition (Other)
KW  - Cognitive training (Other)
KW  - Long-term effects (Other)
KW  - Mild cognitive impairment (Other)
KW  - Non-pharmacological intervention (Other)
KW  - Parkinson’s disease (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC8563628
C6  - pmid:33904966
DO  - DOI:10.1007/s00415-021-10568-9
UR  - https://pub.dzne.de/record/155574
ER  -