guest ::
| Home > Publications Database > Regional Brain and Spinal Cord Volume Loss in Spinocerebellar Ataxia Type 3. > print |
| Home > Publications Database > Regional Brain and Spinal Cord Volume Loss in Spinocerebellar Ataxia Type 3. > print |
| 001 | 155578 | ||
| 005 | 20230915092330.0 | ||
| 024 | 7 | _ | |a pmc:PMC9521507 |2 pmc |
| 024 | 7 | _ | |a 10.1002/mds.28610 |2 doi |
| 024 | 7 | _ | |a pmid:33951232 |2 pmid |
| 024 | 7 | _ | |a 0885-3185 |2 ISSN |
| 024 | 7 | _ | |a 1531-8257 |2 ISSN |
| 024 | 7 | _ | |a altmetric:105366313 |2 altmetric |
| 037 | _ | _ | |a DZNE-2021-00756 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Faber, Jennifer |0 P:(DE-2719)2811327 |b 0 |e First author |
| 245 | _ | _ | |a Regional Brain and Spinal Cord Volume Loss in Spinocerebellar Ataxia Type 3. |
| 260 | _ | _ | |a New York, NY |c 2021 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1681215355_16322 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity.The objective of this study was to quantify regional brain volumes and upper cervical spinal cord areas in spinocerebellar ataxia type 3 in vivo across the entire time course of the disease.We applied a brain segmentation approach that included a lobular subsegmentation of the cerebellum to magnetic resonance images of 210 ataxic and 48 preataxic spinocerebellar ataxia type 3 mutation carriers and 63 healthy controls. In addition, cervical cord cross-sectional areas were determined at 2 levels.The metrics of cervical spinal cord segments C3 and C2, medulla oblongata, pons, and pallidum, and the cerebellar anterior lobe were reduced in preataxic mutation carriers compared with controls. Those of cervical spinal cord segments C2 and C3, medulla oblongata, pons, midbrain, cerebellar lobules crus II and X, cerebellar white matter, and pallidum were reduced in ataxic compared with nonataxic carriers. Of all metrics studied, pontine volume showed the steepest decline across the disease course. It covaried with ataxia severity, CAG repeat length, and age. The multivariate model derived from this analysis explained 46.33% of the variance of pontine volume.Regional brain and spinal cord tissue loss in spinocerebellar ataxia type 3 starts before ataxia onset. Pontine volume appears to be the most promising imaging biomarker candidate for interventional trials that aim at slowing the progression of spinocerebellar ataxia type 3. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a MRI |2 Other |
| 650 | _ | 7 | |a biomarker |2 Other |
| 650 | _ | 7 | |a spinocerebellar ataxia |2 Other |
| 650 | _ | 7 | |a volumetry |2 Other |
| 650 | _ | 2 | |a Brain: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Cerebellum |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Machado-Joseph Disease |2 MeSH |
| 650 | _ | 2 | |a Spinocerebellar Ataxias: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Spinocerebellar Ataxias: genetics |2 MeSH |
| 693 | _ | _ | |0 EXP:(DE-2719)ESMI-20140101 |5 EXP:(DE-2719)ESMI-20140101 |e European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative |x 0 |
| 700 | 1 | _ | |a Schaprian, Tamara |0 P:(DE-2719)2812594 |b 1 |
| 700 | 1 | _ | |a Berkan, Koyak |0 P:(DE-2719)9001550 |b 2 |u dzne |
| 700 | 1 | _ | |a Reetz, Kathrin |0 0000-0002-9730-9228 |b 3 |
| 700 | 1 | _ | |a França, Marcondes Cavalcante |b 4 |
| 700 | 1 | _ | |a de Rezende, Thiago Junqueira Ribeiro |b 5 |
| 700 | 1 | _ | |a Hong, Jiang |0 0000-0003-2812-4120 |b 6 |
| 700 | 1 | _ | |a Liao, Weihua |b 7 |
| 700 | 1 | _ | |a van de Warrenburg, Bart |b 8 |
| 700 | 1 | _ | |a van Gaalen, Judith |b 9 |
| 700 | 1 | _ | |a Dürr, Alexandra |0 P:(DE-2719)9000429 |b 10 |
| 700 | 1 | _ | |a Mochel, Fanny |b 11 |
| 700 | 1 | _ | |a Giunti, Paola |b 12 |
| 700 | 1 | _ | |a Garcia-Moreno, Hector |b 13 |
| 700 | 1 | _ | |a Schoels, Ludger |b 14 |
| 700 | 1 | _ | |a Hengel, Holger |0 P:(DE-2719)2811940 |b 15 |
| 700 | 1 | _ | |a Synofzik, Matthis |0 P:(DE-2719)2811275 |b 16 |
| 700 | 1 | _ | |a Bender, Benjamin |0 P:(DE-2719)9001506 |b 17 |
| 700 | 1 | _ | |a Oz, Gulin |b 18 |
| 700 | 1 | _ | |a Joers, James |b 19 |
| 700 | 1 | _ | |a de Vries, Jereon J |b 20 |
| 700 | 1 | _ | |a Kang, Jun-Suk |b 21 |
| 700 | 1 | _ | |a Timmann-Braun, Dagmar |b 22 |
| 700 | 1 | _ | |a Jacobi, Heike |0 P:(DE-2719)2811564 |b 23 |
| 700 | 1 | _ | |a Infante, Jon |b 24 |
| 700 | 1 | _ | |a Joules, Richard |b 25 |
| 700 | 1 | _ | |a Romanzetti, Sandro |b 26 |
| 700 | 1 | _ | |a Diedrichsen, Jorn |b 27 |
| 700 | 1 | _ | |a Schmid, Matthias |0 P:(DE-2719)2811245 |b 28 |
| 700 | 1 | _ | |a Wolz, Robin |b 29 |
| 700 | 1 | _ | |a Klockgether, Thomas |0 P:(DE-2719)2810314 |b 30 |e Last author |
| 773 | _ | _ | |a 10.1002/mds.28610 |g p. mds.28610 |0 PERI:(DE-600)2041249-6 |n 10 |p 2273-2281 |t Movement disorders |v 36 |y 2021 |x 1531-8257 |
| 856 | 4 | _ | |u https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28610 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/155578/files/19594.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://pub.dzne.de/record/155578/files/19594.pdf?subformat=pdfa |x pdfa |y OpenAccess |
| 909 | C | O | |o oai:pub.dzne.de:155578 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2811327 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2812594 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 2 |6 P:(DE-2719)9001550 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 10 |6 P:(DE-2719)9000429 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 15 |6 P:(DE-2719)2811940 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 16 |6 P:(DE-2719)2811275 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 17 |6 P:(DE-2719)9001506 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 23 |6 P:(DE-2719)2811564 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 28 |6 P:(DE-2719)2811245 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 30 |6 P:(DE-2719)2810314 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-353 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 913 | 0 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-345 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Population Studies and Genetics |x 0 |
| 913 | 0 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-344 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 1 |
| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a Creative Commons Attribution-NonCommercial CC BY-NC 4.0 |0 LIC:(DE-HGF)CCBYNC4 |2 HGFVOC |
| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2021-01-30 |w ger |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-30 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-30 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2022-11-11 |w ger |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b MOVEMENT DISORD : 2021 |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-11 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-11 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b MOVEMENT DISORD : 2021 |d 2022-11-11 |
| 920 | 1 | _ | |0 I:(DE-2719)1011001 |k AG Klockgether |l Clinical Research Coordination |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1210000 |k AG Gasser 1 |l Parkinson Genetics |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1011001 |
| 980 | _ | _ | |a I:(DE-2719)1210000 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|