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000155612 0247_ $$2doi$$a10.1523/ENEURO.0440-20.2020
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000155612 1001_ $$aValero-Aracama, Maria Jesus$$b0
000155612 245__ $$aNoradrenergic Suppression of Persistent Firing in Hippocampal CA1 Pyramidal Cells through cAMP-PKA Pathway.
000155612 260__ $$aWashington, DC$$bSoc.$$c2021
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000155612 520__ $$aPersistent firing is believed to be a cellular correlate of working memory. While the effects of noradrenaline (NA) on working memory have widely been described, its effect on the cellular mechanisms of persistent firing remains largely unknown. Using in vitro intracellular recordings, we demonstrate that persistent firing is supported by individual neurons in hippocampal CA1 pyramidal cells through cholinergic receptor activation, but is dramatically attenuated by NA. In contrast to the classical theory that recurrent synaptic excitation supports persistent firing, suppression of persistent firing by NA was independent of synaptic transmission, indicating that the mechanism is intrinsic to individual cells. In agreement with detrimental effects of cAMP on working memory, we demonstrate that the suppressive effect of NA was through cAMP-PKA pathway. In addition, activation of β1 and/or β3 adrenergic receptors, which increases cAMP levels, suppressed persistent firing. These results are in line with working memory decline observed during high levels of NA and cAMP, which are implicated in high stress, aging, and schizophrenia.
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000155612 650_7 $$2Other$$aM1 receptor
000155612 650_7 $$2Other$$aM2/4 receptors
000155612 650_7 $$2Other$$aPKA
000155612 650_7 $$2Other$$acAMP
000155612 650_7 $$2Other$$apersistent firing
000155612 650_7 $$2Other$$aβ1 adrenoceptors
000155612 650_7 $$0X4W3ENH1CV$$2NLM Chemicals$$aNorepinephrine
000155612 650_2 $$2MeSH$$aHippocampus
000155612 650_2 $$2MeSH$$aNeurons
000155612 650_2 $$2MeSH$$aNorepinephrine
000155612 650_2 $$2MeSH$$aPyramidal Cells
000155612 650_2 $$2MeSH$$aSynaptic Transmission
000155612 7001_ $$0P:(DE-2719)2813728$$aReboreda, Antonio$$b1$$udzne
000155612 7001_ $$0P:(DE-2719)2811871$$aArboit, Alberto$$b2$$udzne
000155612 7001_ $$aSauvage, Magdalena$$b3
000155612 7001_ $$0P:(DE-2719)2811873$$aYoshida, Motoharu$$b4$$eLast author$$udzne
000155612 773__ $$0PERI:(DE-600)2800598-3$$a10.1523/ENEURO.0440-20.2020$$gVol. 8, no. 2, p. ENEURO.0440-20.2020 -$$n2$$pENEURO.0440-20.2020$$teNeuro$$v8$$x2373-2822$$y2021
000155612 8564_ $$uhttps://www.eneuro.org/content/8/2/ENEURO.0440-20.2020.long
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