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@ARTICLE{ValeroAracama:155612,
      author       = {Valero-Aracama, Maria Jesus and Reboreda, Antonio and
                      Arboit, Alberto and Sauvage, Magdalena and Yoshida,
                      Motoharu},
      title        = {{N}oradrenergic {S}uppression of {P}ersistent {F}iring in
                      {H}ippocampal {CA}1 {P}yramidal {C}ells through c{AMP}-{PKA}
                      {P}athway.},
      journal      = {eNeuro},
      volume       = {8},
      number       = {2},
      issn         = {2373-2822},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {DZNE-2021-00780},
      pages        = {ENEURO.0440-20.2020},
      year         = {2021},
      abstract     = {Persistent firing is believed to be a cellular correlate of
                      working memory. While the effects of noradrenaline (NA) on
                      working memory have widely been described, its effect on the
                      cellular mechanisms of persistent firing remains largely
                      unknown. Using in vitro intracellular recordings, we
                      demonstrate that persistent firing is supported by
                      individual neurons in hippocampal CA1 pyramidal cells
                      through cholinergic receptor activation, but is dramatically
                      attenuated by NA. In contrast to the classical theory that
                      recurrent synaptic excitation supports persistent firing,
                      suppression of persistent firing by NA was independent of
                      synaptic transmission, indicating that the mechanism is
                      intrinsic to individual cells. In agreement with detrimental
                      effects of cAMP on working memory, we demonstrate that the
                      suppressive effect of NA was through cAMP-PKA pathway. In
                      addition, activation of β1 and/or β3 adrenergic receptors,
                      which increases cAMP levels, suppressed persistent firing.
                      These results are in line with working memory decline
                      observed during high levels of NA and cAMP, which are
                      implicated in high stress, aging, and schizophrenia.},
      keywords     = {Hippocampus / Neurons / Norepinephrine / Pyramidal Cells /
                      Synaptic Transmission / M1 receptor (Other) / M2/4 receptors
                      (Other) / PKA (Other) / cAMP (Other) / persistent firing
                      (Other) / β1 adrenoceptors (Other) / Norepinephrine (NLM
                      Chemicals)},
      cin          = {AG Yoshida / AG Angenstein},
      ddc          = {610},
      cid          = {I:(DE-2719)1310011 / I:(DE-2719)1310004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33637539},
      pmc          = {pmc:PMC8009666},
      doi          = {10.1523/ENEURO.0440-20.2020},
      url          = {https://pub.dzne.de/record/155612},
}