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000155621 037__ $$aDZNE-2021-00789
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000155621 1001_ $$0P:(DE-2719)9000295$$aShafiq, Mohsin$$b0$$eFirst author
000155621 245__ $$aPrion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer's disease.
000155621 260__ $$aLondon$$bBiomed Central$$c2021
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000155621 520__ $$aHigh-density oligomers of the prion protein (HDPs) have previously been identified in brain tissues of patients with rapidly progressive Alzheimer's disease (rpAD). The current investigation aims at identifying interacting partners of HDPs in the rpAD brains to unravel the pathological involvement of HDPs in the rapid progression.HDPs from the frontal cortex tissues of rpAD brains were isolated using sucrose density gradient centrifugation. Proteins interacting with HDPs were identified by co-immunoprecipitation coupled with mass spectrometry. Further verifications were carried out using proteomic tools, immunoblotting, and confocal laser scanning microscopy.We identified rpAD-specific HDP-interactors, including the growth arrest specific 2-like 2 protein (G2L2). Intriguingly, rpAD-specific disturbances were found in the localization of G2L2 and its associated proteins i.e., the end binding protein 1, α-tubulin, and β-actin.The results show the involvement of HDPs in the destabilization of the neuronal actin/tubulin infrastructure. We consider this disturbance to be a contributing factor for the rapid progression in rpAD.
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000155621 650_7 $$2Other$$aActin
000155621 650_7 $$2Other$$aCo-immunoprecipitation
000155621 650_7 $$2Other$$aCytoskeleton
000155621 650_7 $$2Other$$aG2L2
000155621 650_7 $$2Other$$aGAS
000155621 650_7 $$2Other$$aGrowth arrest specific 2 like 2
000155621 650_7 $$2Other$$aGrowth arrest specific proteins
000155621 650_7 $$2Other$$aPrPC
000155621 650_7 $$2Other$$aPrion protein oligomers
000155621 650_7 $$2Other$$aRapidly progressive Alzheimer’s disease
000155621 650_7 $$2Other$$aTubulin
000155621 650_7 $$2Other$$arpAD
000155621 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000155621 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000155621 650_2 $$2MeSH$$aBrain: metabolism
000155621 650_2 $$2MeSH$$aCytoskeleton: metabolism
000155621 650_2 $$2MeSH$$aCytoskeleton: pathology
000155621 650_2 $$2MeSH$$aDisease Progression
000155621 650_2 $$2MeSH$$aHumans
000155621 650_2 $$2MeSH$$aNeurons: metabolism
000155621 650_2 $$2MeSH$$aPrion Proteins: metabolism
000155621 7001_ $$0P:(DE-2719)9000358$$aZafar, Saima$$b1
000155621 7001_ $$0P:(DE-2719)9001558$$aYounas, Neelam$$b2$$udzne
000155621 7001_ $$0P:(DE-2719)9001208$$aNoor, Aneeqa$$b3
000155621 7001_ $$aPuig, Berta$$b4
000155621 7001_ $$aAltmeppen, Hermann Clemens$$b5
000155621 7001_ $$0P:(DE-2719)9000287$$aSchmitz, Matthias$$b6
000155621 7001_ $$aMatschke, Jakob$$b7
000155621 7001_ $$aFerrer, Isidre$$b8
000155621 7001_ $$aGlatzel, Markus$$b9
000155621 7001_ $$0P:(DE-2719)2000058$$aZerr, Inga$$b10$$eLast author
000155621 773__ $$0PERI:(DE-600)2244557-2$$a10.1186/s13024-021-00422-x$$gVol. 16, no. 1, p. 11$$n1$$p11$$tMolecular neurodegeneration$$v16$$x1750-1326$$y2021
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